Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Jetse Scholma"'
Autor:
Sakshi Khurana, Stefano Schivo, Jacqueline R. M. Plass, Nikolas Mersinis, Jetse Scholma, Johan Kerkhofs, Leilei Zhong, Jaco van de Pol, Rom Langerak, Liesbet Geris, Marcel Karperien, Janine N. Post
Publikováno v:
Frontiers in Bioengineering and Biotechnology, Vol 9 (2021)
A fundamental question in cartilage biology is: what determines the switch between permanent cartilage found in the articular joints and transient hypertrophic cartilage that functions as a template for bone? This switch is observed both in a subset
Externí odkaz:
https://doaj.org/article/7987b8cda5b64370984e24d6236274bd
Autor:
Stefano Schivo, Jetse Scholma, Marcel Karperien, Janine N. Post, Jaco van de Pol, Rom Langerak
Publikováno v:
Electronic Proceedings in Theoretical Computer Science, Vol 145, Iss Proc. SynCoP 2014, Pp 35-47 (2014)
ANIMO (Analysis of Networks with Interactive MOdeling) is a software for modeling biological networks, such as e.g. signaling, metabolic or gene networks. An ANIMO model is essentially the sum of a network topology and a number of interaction paramet
Externí odkaz:
https://doaj.org/article/da95cd0e91104b5d887cbfbee9a024ba
Autor:
Andrea Tuettenberg, Susanne A Hahn, Johanna Mazur, Aslihan Gerhold-Ay, Jetse Scholma, Iris Marg, Alexander Ulges, Kazuki Satoh, Tobias Bopp, Jos Joore, Helmut Jonuleit
Publikováno v:
PLoS ONE, Vol 11, Iss 2, p e0149193 (2016)
Regulatory T cells (Treg) are essential for T cell homeostasis and maintenance of peripheral tolerance. They prevent activation of auto-reactive T effector cells (Teff) in the context of autoimmunity and allergy. Otherwise, Treg also inhibit effectiv
Externí odkaz:
https://doaj.org/article/f21ed477c60c446fbfa47524dbc9c07a
Autor:
Jetse Scholma, Liesbet Geris, Janine N. Post, Jaco van de Pol, Sakshi Khurana, Rom Langerak, Stefano Schivo, Kannan Govindaraj, Johan Kerkhofs, Marcel Karperien, Xiaobin Huang, Andre J. van Wijnen, Leilei Zhong
Publikováno v:
Schivo, S, Khurana, S, Govindaraj, K, Scholma, J, Kerkhofs, J, Zhong, L, Huang, X, van de Pol, J, Langerak, R, van Wijnen, A J, Geris, L, Karperien, M & Post, J N 2020, ' ECHO, the executable CHOndrocyte : A computational model to study articular chondrocytes in health and disease ', Cellular Signalling, vol. 68, 109471 . https://doi.org/10.1016/j.cellsig.2019.109471
Cellular Signalling, 68:109471. Elsevier Inc.
Cellular Signalling, 68:109471. Elsevier
Schivo, S, Khurana, S, Govindaraj, K, Scholma, J, Kerkhofs, J, Zhong, L, Huang, X, Pol, J V D, Langerak, R, Wijnen, A J V, Geris, L, Karperien, M & Post, J N 2019, ' ECHO, the executable CHOndrocyte: A computational model to study articular chondrocytes in healthy and disease ', Cellular Signalling . https://doi.org/10.1016/j.cellsig.2019.109471
Cellular Signalling, 68:109471. Elsevier Inc.
Cellular Signalling, 68:109471. Elsevier
Schivo, S, Khurana, S, Govindaraj, K, Scholma, J, Kerkhofs, J, Zhong, L, Huang, X, Pol, J V D, Langerak, R, Wijnen, A J V, Geris, L, Karperien, M & Post, J N 2019, ' ECHO, the executable CHOndrocyte: A computational model to study articular chondrocytes in healthy and disease ', Cellular Signalling . https://doi.org/10.1016/j.cellsig.2019.109471
Computational modeling can be used to investigate complex signaling networks in biology. However, most modeling tools are not suitable for molecular cell biologists with little background in mathematics. We have built a visual-based modeling tool for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18dd3e18d306a6fd950ea89a5e3420b0
https://hdl.handle.net/1820/c8afbf16-bbcd-4716-a850-c0f96f5f0326
https://hdl.handle.net/1820/c8afbf16-bbcd-4716-a850-c0f96f5f0326
Autor:
Stanley Nattel, Sander H. Diks, Femke Hoogstra-Berends, Roelien A. M. Meijering, Xiao Yan Qi, Natasja M.S. de Groot, Eva A.H. Lanters, Robert H. Henning, Bianca J. J. M. Brundel, Marit Wiersma, Jetse Scholma, Deli Zhang
Publikováno v:
Heart Rhythm, 15(11), 1708-1716. Elsevier
Heart Rhythm, 15(11), 1708-1716
Heart Rhythm, 15(11), 1708-1716. ELSEVIER SCIENCE INC
Meijering, R A M, Wiersma, M, Zhang, D, Lanters, E A H, Hoogstra-Berends, F, Scholma, J, Diks, S, Qi, X Y, de Groot, N M S, Nattel, S, Henning, R H & Brundel, B J J M 2018, ' Application of kinomic array analysis to screen for altered kinases in atrial fibrillation remodeling ', Heart Rhythm, vol. 15, no. 11, pp. 1708-1716 . https://doi.org/10.1016/j.hrthm.2018.06.014
Heart Rhythm 15 (2018) 11
Heart Rhythm, 15(11), 1708-1716
Heart Rhythm, 15(11), 1708-1716. ELSEVIER SCIENCE INC
Meijering, R A M, Wiersma, M, Zhang, D, Lanters, E A H, Hoogstra-Berends, F, Scholma, J, Diks, S, Qi, X Y, de Groot, N M S, Nattel, S, Henning, R H & Brundel, B J J M 2018, ' Application of kinomic array analysis to screen for altered kinases in atrial fibrillation remodeling ', Heart Rhythm, vol. 15, no. 11, pp. 1708-1716 . https://doi.org/10.1016/j.hrthm.2018.06.014
Heart Rhythm 15 (2018) 11
BACKGROUND: Dysregulation of protein kinase-mediated signaling is an early event in many diseases, including the most common clinical cardiac arrhythmia, atrial fibrillation (AF). Kinomic profiling represents a promising technique to identify candida
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::271e685a5009e9bab6609c22dbace0c5
https://research.vumc.nl/en/publications/56ac37b2-5b7a-4e12-87af-c9d6fee2727b
https://research.vumc.nl/en/publications/56ac37b2-5b7a-4e12-87af-c9d6fee2727b
Autor:
Marcel J. T. Reinders, Jos Joore, Alan F. List, Maikel P. Peppelenbosch, Jetse Scholma, Marc Hulsman, Janine N. Post, Stefano Schivo, Gwenny M. Fuhler
Publikováno v:
Scientific Reports, 6:26695. Nature Publishing Group
Scientific Reports
Scientific reports, 6:26695. Nature Publishing Group
Scholma, J, Fuhler, G M, Joore, J, Hulsman, M, Schivo, S, List, A F, Reinders, M J T, Peppelenbosch, M P & Post, J N 2016, ' Improved intra-array and interarray normalization of peptide microarray phosphorylation for phosphorylome and kinome profiling by rational selection of relevant spots ', Scientific Reports, vol. 6, 26695 . https://doi.org/10.1038/srep26695
Scientific Reports, 6. Nature Publishing Group
Scientific Reports
Scientific reports, 6:26695. Nature Publishing Group
Scholma, J, Fuhler, G M, Joore, J, Hulsman, M, Schivo, S, List, A F, Reinders, M J T, Peppelenbosch, M P & Post, J N 2016, ' Improved intra-array and interarray normalization of peptide microarray phosphorylation for phosphorylome and kinome profiling by rational selection of relevant spots ', Scientific Reports, vol. 6, 26695 . https://doi.org/10.1038/srep26695
Scientific Reports, 6. Nature Publishing Group
Massive parallel analysis using array technology has become the mainstay for analysis of genomes and transcriptomes. Analogously, the predominance of phosphorylation as a regulator of cellular metabolism has fostered the development of peptide arrays
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9b0a4ae9b0d3d61159e045a09af6b31
https://research.vumc.nl/en/publications/4ffce236-b9a4-4cb1-9804-2fd14c32d39c
https://research.vumc.nl/en/publications/4ffce236-b9a4-4cb1-9804-2fd14c32d39c
Autor:
Jaco van de Pol, Stefano Schivo, Marcel Karperien, Paul van der Vet, Jetse Scholma, Janine N. Post, Rom Langerak
Publikováno v:
BMC Systems Biology
BMC systems biology, 10. BioMed Central
BMC systems biology, 10. BioMed Central
Background Computational support is essential in order to reason on the dynamics of biological systems. We have developed the software tool ANIMO (Analysis of Networks with Interactive MOdeling) to provide such computational support and allow insight
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8fa03a8e09a22e32e2b81509d11f348a
https://pubmed.ncbi.nlm.nih.gov/27460034
https://pubmed.ncbi.nlm.nih.gov/27460034
Autor:
Karla C. S. Queiroz, Susan Goorden, Marco J. Bruno, Maria M. Alves, C. Arnold Spek, Jasper J. Anink, Mark Nellist, Eleonora Aronica, Maikel P. Peppelenbosch, Jetse Scholma, Gwenny M. Fuhler, Ype Elgersma, Marianne Hoogeveen-Westerveld
Publikováno v:
Scientific reports, 5. Nature Publishing Group
Scientific Reports, 5:14534. Nature Publishing Group
Scientific Reports, 5. Nature Publishing Group
Scientific Reports
Scientific Reports, 5:14534. Nature Publishing Group
Scientific Reports, 5. Nature Publishing Group
Scientific Reports
Tuberous sclerosis complex (TSC) is caused by inactivating mutations in either TSC1 or TSC2 and is characterized by uncontrolled mTORC1 activation. Drugs that reduce mTOR activity are only partially successful in the treatment of TSC, suggesting that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c418525df63a1314d8d4a2b37c7c1d6
https://pure.amc.nl/en/publications/pak2-is-an-effector-of-tsc12-signaling-independent-of-mtor-and-a-potential-therapeutic-target-for-tuberous-sclerosis-complex(1b097c6c-42e5-4546-8670-4a2d7632363e).html
https://pure.amc.nl/en/publications/pak2-is-an-effector-of-tsc12-signaling-independent-of-mtor-and-a-potential-therapeutic-target-for-tuberous-sclerosis-complex(1b097c6c-42e5-4546-8670-4a2d7632363e).html
Autor:
Paul van der Vet, Marcel Karperien, Stefano Schivo, Brend Wanders, Jetse Scholma, Ricardo A. Urquidi Camacho, Jaco van de Pol, Rom Langerak, Janine N. Post
Publikováno v:
IEEE journal of biomedical and health informatics, 18(3), 832-839. IEEE
Living cells are constantly subjected to a plethora of environmental stimuli that require integration into an appropriate cellular response. This integration takes place through signal transduction events that form tightly interconnected networks. Th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a922f511d21d5bfe74754b5ffa025e9
https://pubmed.ncbi.nlm.nih.gov/24808226
https://pubmed.ncbi.nlm.nih.gov/24808226
Autor:
Ricardo A. Urquidi Camacho, Janine N. Post, Marcel Karperien, Jaco van de Pol, Jetse Scholma, Stefano Schivo
Publikováno v:
Gene, 533(42), 379-384. Elsevier
Computational modeling of biological networks permits the comprehensive analysis of cells and tissues to define molecular phenotypes and novel hypotheses. Although a large number of software tools have been developed, the versatility of these tools i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9137202b437bb60629cb4051633ac96f
https://pubmed.ncbi.nlm.nih.gov/24125950
https://pubmed.ncbi.nlm.nih.gov/24125950