Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Jesus Perez-Losada"'
Autor:
Hui Yang, Xinzhi Wang, Adrián Blanco-Gómez, Li He, Natalia García-Sancha, Roberto Corchado-Cobos, Manuel Jesús Pérez-Baena, Alejandro Jiménez-Navas, Pin Wang, Jamie L. Inman, Antoine M. Snijders, David W. Threadgill, Allan Balmain, Hang Chang, Jesus Perez-Losada, Jian-Hua Mao
Publikováno v:
EBioMedicine, Vol 106, Iss , Pp 105260- (2024)
Summary: Background: Deeper insights into ERBB2-driven cancers are essential to develop new treatment approaches for ERBB2+ breast cancers (BCs). We employed the Collaborative Cross (CC) mouse model to unearth genetic factors underpinning Erbb2-drive
Externí odkaz:
https://doaj.org/article/6fe0af1cc003460fbba638da01b6d216
Publikováno v:
Frontiers in Oncology, Vol 13 (2023)
Increased mitotic activity is associated with the genesis and aggressiveness of many cancers. To assess the clinical value of mitotic activity as prognostic biomarker, we performed a pan-cancer study on the mitotic network activity index (MNAI) const
Externí odkaz:
https://doaj.org/article/d8066da062824e1cb01d24436d84c2cd
Autor:
Yi Xiao, Chunli Yin, Yuli Wang, Hanlin Lv, Wenqing Wang, Yurong Huang, Jesus Perez‐Losada, Antoine M. Snijders, Jian‐Hua Mao, Pengju Zhang
Publikováno v:
Molecular Oncology, Vol 12, Iss 6, Pp 883-895 (2018)
Gefitinib, an epidermal growth factor receptor–tyrosine kinase inhibitor (EGFR‐TKI), is an effective treatment for non‐small‐cell lung cancer (NSCLC) with EGFR activating mutations, but inevitably, the clinical efficacy is impeded by the emer
Externí odkaz:
https://doaj.org/article/c5520567791d4b7b8da29f0bd15cb759
Publikováno v:
Cells, Vol 10, Iss 10, p 2590 (2021)
Secreted angiopoietin/angiopoietin-like (ANGPT/ANGPTL) proteins are involved in many biological processes. However, the role of these proteins in human breast cancers (BCs) remains largely unclear. Here, we conducted integrated omics analyses to eval
Externí odkaz:
https://doaj.org/article/fe60aab5fb8a4e08a05aa47b2db8af62
Autor:
Yueyong Liu, Shancheng Ren, Andres Castellanos-Martin, Jesus Perez-Losada, Yong-Won Kwon, Yurong Huang, Zeran Wang, Mar Abad, Juan J Cruz-Hernandez, Cesar A Rodriguez, Yinghao Sun, Jian-Hua Mao
Publikováno v:
PLoS ONE, Vol 7, Iss 11, p e49453 (2012)
FBXW7 acts as a tumor suppressor through ubiquitination and degradation of multiple oncoproteins. Loss of FBXW7 expression, which could be partially attributed by the genomic deletion or mutation of FBXW7 locus, is frequently observed in various huma
Externí odkaz:
https://doaj.org/article/b054fd8c0534492cadfa25ec4daa76a7
Publikováno v:
PLoS ONE, Vol 7, Iss 2, p e31301 (2012)
Genome-wide association studies (GWAS) have been successful in finding associations between specific genetic variants and cancer susceptibility in human populations. These studies have identified a range of highly statistically significant associatio
Externí odkaz:
https://doaj.org/article/b78b1717d9b844168cbe62d0cb3dc140
Autor:
Jian-Hua Mao, Allan Balmain, Guangwei Wei, Jesus Perez-Losada, Kuang-Yu Jen, Reyno DelRosario, Hio Chung Kang, Yurong Huang, Yueyong Liu, William A. Stock, Jing Lu, Di Wu, Il-Jin Kim, Yong-Won Kwon
PDF file - 222K
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::409d249f5270f369a43e725ff50207e6
https://doi.org/10.1158/1541-7786.22516908.v1
https://doi.org/10.1158/1541-7786.22516908.v1
Autor:
Jian-Hua Mao, Allan Balmain, Guangwei Wei, Jesus Perez-Losada, Kuang-Yu Jen, Reyno DelRosario, Hio Chung Kang, Yurong Huang, Yueyong Liu, William A. Stock, Jing Lu, Di Wu, Il-Jin Kim, Yong-Won Kwon
The Aurora-A kinase gene is frequently amplified and/or overexpressed in a variety of human cancers, leading to major efforts to develop therapeutic agents targeting this pathway. Here, we show that Aurora-A is targeted for ubiquitination and subsequ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4683175472a6d135526e2086cb935038
https://doi.org/10.1158/1541-7786.c.6541539
https://doi.org/10.1158/1541-7786.c.6541539
Autor:
Rosemary J. Akhurst, Boris C. Bastian, Ervin H. Epstein, Dan H. Moore, Jesus Perez-Losada, Frederic F. Clermont, Elise F. Saunier, Katie Ridd, Kelly A. Harradine
Supplementary Data from Elevated Cutaneous Smad Activation Associates with Enhanced Skin Tumor Susceptibility in Organ Transplant Recipients
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d77ef7646c59fbdb3f2b821057c43efd
https://doi.org/10.1158/1078-0432.22440289
https://doi.org/10.1158/1078-0432.22440289
Autor:
Rosemary J. Akhurst, Boris C. Bastian, Ervin H. Epstein, Dan H. Moore, Jesus Perez-Losada, Frederic F. Clermont, Elise F. Saunier, Katie Ridd, Kelly A. Harradine
Purpose: Nonmelanoma skin cancer incidence is enhanced >50-fold in patients taking antirejection drugs (ARD) following organ transplantation. Preclinical studies suggest that ARD treatment increases transforming growth factor-β1 (TGF-β1) levels, wh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23d1305de02cb2d765327d16e3d66c22
https://doi.org/10.1158/1078-0432.c.6517639.v1
https://doi.org/10.1158/1078-0432.c.6517639.v1