Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Jesus Pacheco-Torres"'
Autor:
Jesus Pacheco-Torres, Raj Kumar Sharma, Yelena Mironchik, Flonne Wildes, W. Nathaniel Brennen, Dmitri Artemov, Balaji Krishnamachary, Zaver M. Bhujwalla
Publikováno v:
Frontiers in Molecular Biosciences, Vol 11 (2024)
Fibroblasts are versatile cells that play a major role in wound healing by synthesizing and remodeling the extracellular matrix (ECM). In cancers, fibroblasts play an expanded role in tumor progression and dissemination, immunosuppression, and metabo
Externí odkaz:
https://doaj.org/article/b82b6850e65b4f2a8e102224b072f600
Autor:
Jesus Pacheco-Torres, Marie-France Penet, Yelena Mironchik, Balaji Krishnamachary, Zaver M. Bhujwalla
Publikováno v:
Cancer & Metabolism, Vol 9, Iss 1, Pp 1-16 (2021)
Abstract Background Harnessing the power of the immune system by using immune checkpoint inhibitors has resulted in some of the most exciting advances in cancer treatment. The full potential of this approach has, however, not been fully realized for
Externí odkaz:
https://doaj.org/article/8db68ae8c2c048e9baa726a3d17de458
Autor:
Dominick Salerno, Alaina Howe, Omkar Bhatavdekar, Anders Josefsson, Jesus Pacheco‐Torres, Zaver M. Bhujwalla, Kathleen L. Gabrielson, Stavroula Sofou
Publikováno v:
Bioengineering & Translational Medicine, Vol 7, Iss 2, Pp n/a-n/a (2022)
Abstract Partial and/or heterogeneous irradiation of established (i.e., large, vascularized) tumors by α‐particles that exhibit only a 4–5 cell‐diameter range in tissue, limits the therapeutic effect, since regions not being hit by the high en
Externí odkaz:
https://doaj.org/article/f3d7177fd9af4ec7b084eb2668ffc9e0
Autor:
Jesus Pacheco-Torres, Marie-France Penet, Balaji Krishnamachary, Yelena Mironchik, Zhihang Chen, Zaver M. Bhujwalla
Publikováno v:
Frontiers in Oncology, Vol 10 (2021)
PurposeThe inhibition of immune checkpoints such as programmed cell death ligand-1 (PD-L1/CD274) with antibodies is providing novel opportunities to expose cancer cells to the immune system. Antibody based checkpoint blockade can, however, result in
Externí odkaz:
https://doaj.org/article/860445ef813442d6894c50ba732f14e3
Publikováno v:
NMR in biomedicine. 35(11)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e38d9139687a2a675e2445a0137ae2d
https://pubmed.ncbi.nlm.nih.gov/36071604
https://pubmed.ncbi.nlm.nih.gov/36071604
Autor:
George Sgouros, Stavroula Sofou, Omkar Bhatavdekar, Dominick Salerno, Alaina Howe, Aprameya Prasad, Rajiv Nair, Michelle Sempkowski, Kathleen L. Gabrielson, Jesus Pacheco-Torres, Zaver M. Bhujwalla, Anders Josefsson
Publikováno v:
European Journal of Nuclear Medicine and Molecular Imaging. 48:4246-4258
Highly cytotoxic α-particle radiotherapy delivered by tumor-selective nanocarriers is evaluated on metastatic Triple Negative Breast Cancer (TNBC). On vascularized tumors, the limited penetration of nanocarriers (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ea680cd71beee8f25887ce4893d8e02
https://doi.org/10.1007/s00259-021-05406-z
https://doi.org/10.1007/s00259-021-05406-z
Autor:
Tianqi Nie, Lixin Liu, Zhiyu He, Jinchang Zhu, Il Minn, Jesus Pacheco-Torres, Kuntao Chen, Pengfei Zhao, Gregory P. Howard, Hai-Quan Mao, Yongming Chen, Zaver M. Bhujwalla
Publikováno v:
Nano Research. 14:2749-2761
Levodopa (L-DOPA), a precursor of dopamine, is commonly prescribed for the treatment of the Parkinson’s disease (PD). However, oral administration of levodopa results in a high level of homocysteine in the peripheral circulation, thereby elevating
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bf3a51874346d20c93d00a30719ec844
https://doi.org/10.1007/s12274-020-3280-0
https://doi.org/10.1007/s12274-020-3280-0
Autor:
Zaver M. Bhujwalla, Stavroula Sofou, Kathleen L. Gabrielson, Jesus Pacheco-Torres, Omkar Bhatavdekar, Anders Josefsson, Alaina Howe, Dominick Salerno
Publikováno v:
Bioengineeringtranslational medicine. 7(2)
Partial and/or heterogeneous irradiation of established (i.e., large, vascularized) tumors by α-particles that exhibit only a 4-5 cell-diameter range in tissue, limits the therapeutic effect, since regions not being hit by the high energy α-particl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::260f0961caee85f7e39e01126a62cc18
https://pubmed.ncbi.nlm.nih.gov/35600657
https://pubmed.ncbi.nlm.nih.gov/35600657
Autor:
Flonne Wildes, Yelena Mironchik, Marie-France Penet, Balaji Krishnamachary, Zaver M. Bhujwalla, Jesus Pacheco-Torres
Publikováno v:
Molecular and Cellular Biology / Genetics
Introduction Cancer immunotherapy is designed to activate the immune system against cancer cells. This field has been revitalized with the discovery of immune checkpoints such as programmed cell death protein-1 (PD-1) and its ligand (PD-L1). PD-L1 ha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d45e21a89292675410ed400eb0ad468e
https://doi.org/10.1158/1538-7445.am2020-2546
https://doi.org/10.1158/1538-7445.am2020-2546
Autor:
Balaji Krishnamachary, Jesus Pacheco-Torres, Zaver M. Bhujwalla, Zhihang Chen, M.G. Pomper, Marie-France Penet, Sangeeta Ray, Yelena Mironchik
Publikováno v:
Cancer Research. 79:1135-1135
Introduction: Targeted nanoparticles (NPs) containing imaging reporters provide exciting options for cancer-specific delivery of siRNA to downregulate specific pathways in theranostic strategies. We recently developed a biodegradable modified dextran
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7193205ace6264d0dacd2009394b6a86
https://doi.org/10.1158/1538-7445.am2019-1135
https://doi.org/10.1158/1538-7445.am2019-1135