Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Jesus Pérez-Gil"'
Publikováno v:
Current Research in Toxicology, Vol 2, Iss , Pp 225-236 (2021)
Inhaled substances, such as consumer products, chemicals at the workplace, and nanoparticles, can affect the lung function in several ways. In this paper, we explore the adverse outcome pathway (AOP) that starts when inhaled substances that reach the
Externí odkaz:
https://doaj.org/article/2adb973f5c6c40bb95c0328ddec734ff
Autor:
Benedikt Huck, Alberto Hidalgo, Franziska Waldow, Dominik Schwudke, Karoline I. Gaede, Claus Feldmann, Patrick Carius, Chiara Autilio, Jesus Pérez-Gil, Konrad Schwarzkopf, Xabier Murgia, Brigitta Loretz, Claus-Michael Lehr
Publikováno v:
Small Science, Vol 1, Iss 12, Pp n/a-n/a (2021)
The interplay of particles with pulmonary surfactant, a lipid‐protein material pivotal for lung function, is hypothesized as a key factor that has not been routinely considered in the current in vitro models when determining the fate of inhaled nan
Externí odkaz:
https://doaj.org/article/9bbd7c9cd0c448ae95b5eb07a31d19ef
Autor:
Roberta Guagliardo, Pieterjan Merckx, Agata Zamborlin, Lynn De Backer, Mercedes Echaide, Jesus Pérez-Gil, Stefaan C. De Smedt, Koen Raemdonck
Publikováno v:
Pharmaceutics, Vol 11, Iss 9, p 431 (2019)
Two decades since the discovery of the RNA interference (RNAi) pathway, we are now witnessing the approval of the first RNAi-based treatments with small interfering RNA (siRNA) drugs. Nevertheless, the widespread use of siRNA is limited by various ex
Externí odkaz:
https://doaj.org/article/365b0f600804478bbe71c4ba8dbbceb5
Autor:
Jesús Pérez-Gil
Publikováno v:
Biomedical Journal, Vol 45, Iss 4, Pp 615-628 (2022)
The lives of thousands premature babies have been saved along the last thirty years thanks to the establishment and consolidation of pulmonary surfactant replacement therapies (SRT). It took some time to close the gap between the identification of th
Externí odkaz:
https://doaj.org/article/14cfe94bf0a3439a9275554de4449c8e
Autor:
Lidia Feo-Lucas, Cristina Godio, María Minguito de la Escalera, Natalia Alvarez-Ladrón, Laura H. Villarrubia, Adrián Vega-Pérez, Leticia González-Cintado, Jorge Domínguez-Andrés, Belén García-Fojeda, Carlos Montero-Fernández, Cristina Casals, Chiara Autilio, Jesús Pérez-Gil, Georgiana Crainiciuc, Andrés Hidalgo, María López-Bravo, Carlos Ardavín
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Respiratory disorders caused by allergy have been associated to bronchiolar inflammation leading to life-threatening airway narrowing. However, whether airway allergy causes alveolar dysfunction contributing to the pathology of allergic asthma remain
Externí odkaz:
https://doaj.org/article/3f66a8b083034c48bba53e50f4d065f2
Autor:
Daniele De Luca, Paola Cogo, Martin C. Kneyber, Paolo Biban, Malcolm Grace Semple, Jesus Perez-Gil, Giorgio Conti, Pierre Tissieres, Peter C. Rimensberger
Publikováno v:
Critical Care, Vol 25, Iss 1, Pp 1-12 (2021)
Abstract Pediatric (PARDS) and neonatal (NARDS) acute respiratory distress syndrome have different age-specific characteristics and definitions. Trials on surfactant for ARDS in children and neonates have been performed well before the PARDS and NARD
Externí odkaz:
https://doaj.org/article/b1d7a7a7bde940429e33fe783eb457c6
Autor:
Hanna Korolainen, Fabio Lolicato, Giray Enkavi, Jesús Pérez-Gil, Waldemar Kulig, Ilpo Vattulainen
Publikováno v:
PLoS ONE, Vol 17, Iss 4, p e0267155 (2022)
Surfactant protein C (SP-C) has several functions in pulmonary surfactant. These include the transfer of lipids between different membrane structures, a role in surfactant recycling and homeostasis, and involvement in modulation of the innate defense
Externí odkaz:
https://doaj.org/article/972cee1b06c0485593efecdf911aea4f
Autor:
Cristina García-Mouton, Mercedes Echaide, Luis A. Serrano, Guillermo Orellana, Fabrizio Salomone, Francesca Ricci, Barbara Pioselli, Davide Amidani, Antonio Cruz, Jesús Pérez-Gil
Publikováno v:
Pharmaceutics, Vol 15, Iss 1, p 256 (2023)
Pulmonary surfactant (PS) has been proposed as an efficient drug delivery vehicle for inhaled therapies. Its ability to adsorb and spread interfacially and transport different drugs associated with it has been studied mainly by different surface bala
Externí odkaz:
https://doaj.org/article/93795d80df1447528e8bb099804d4e54
Publikováno v:
Journal of Lipid Research, Vol 60, Iss 2, Pp 430-435 (2019)
TLC has traditionally been used to analyze lipids isolated from membrane complexes. Here, we describe a method based on the combination of TLC and SDS-PAGE to qualitatively analyze the protein/lipid profile of membrane complexes such as those of lung
Externí odkaz:
https://doaj.org/article/b22bf73754d9469cbd0071a3f5c0200f
Autor:
Cristina García-Mouton, Alberto Hidalgo, Raquel Arroyo, Mercedes Echaide, Antonio Cruz, Jesús Pérez-Gil
Publikováno v:
Frontiers in Bioengineering and Biotechnology, Vol 8 (2021)
This work is focused on the potential use of pulmonary surfactant to deliver full-length recombinant human surfactant protein SP-D (rhSP-D) using the respiratory air-liquid interface as a shuttle. Surfactant protein D (SP-D) is a collectin protein pr
Externí odkaz:
https://doaj.org/article/39395447eba242a4beb9afe35224e2f5