Zobrazeno 1 - 10
of 141
pro vyhledávání: '"Jesus M, Aizpurua"'
Autor:
Rossana Passannante, Vanessa Gómez-Vallejo, Maialen Sagartzazu-Aizpurua, Laura Vignau Arsuaga, Pablo Marco-Moreno, Garazi Aldanondo, Ainara Vallejo-Illarramendi, Pablo Aguiar, Unai Cossío, Abraham Martín, Jonas Bergare, Lee Kingston, Charles S. Elmore, Miguel Angel Morcillo, Pablo Ferrón, Jesus M. Aizpurua, Jordi Llop
Publikováno v:
Biomedicines, Vol 11, Iss 2, p 253 (2023)
Background and objective: The determination of pharmacokinetic properties of new chemical entities is a key step in the process of drug development. Positron emission tomography (PET) is an ideal technique to obtain both biodistribution and pharmacok
Externí odkaz:
https://doaj.org/article/ed7d132499034dc9b7f57f0c9ecdfc0f
Autor:
Garazi Aldanondo, Maite Eceiza, José I. Miranda, Ainara Vallejo-Illarramendi, Maialen Sagartzazu-Aizpurua, Pablo Marco-Moreno, Aitziber Irastorza, Pablo Ferrón, Jesus M. Aizpurua, Adolfo López de Munain, Haizpea Lasa-Fernández, Endika Torres, Naroa Dadie
Publikováno v:
European Journal of Medicinal Chemistry. 213:113160
The hypothesis of rescuing FKBP12/RyR1 interaction and intracellular calcium homeostasis through molecular “reshaping” of FKBP12 was investigated. To this end, novel 4-arylthioalkyl-1-carboxyalkyl-1,2,3-triazoles were designed and synthesized, an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e66a6ca5e17c6c75233ec206da4a3755
https://doi.org/10.1016/j.ejmech.2021.113160
https://doi.org/10.1016/j.ejmech.2021.113160
Autor:
Jesus M. Aizpurua, Maite Insausti, Borja Herrero de la Parte, Ignacio García-Alonso, Jose Javier Echevarría-Uraga, Maialen Sagartzazu, Alberto Saiz-López, Mireia Irazola, Oihane Arriortua, José Ángel García, Luis Lezama, Nestor Etxebarria, Eneko Garaio, Fernando Plazaola
Publikováno v:
Beilstein Journal of Nanotechnology
Beilstein Journal of Nanotechnology, Vol 7, Iss 1, Pp 1532-1542 (2016)
Beilstein Journal of Nanotechnology, Vol 7, Iss 1, Pp 1532-1542 (2016)
This work reports important advances in the study of magnetic nanoparticles (MNPs) related to their application in different research fields such as magnetic hyperthermia. Nanotherapy based on targeted nanoparticles could become an attractive alterna
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d0b3f2d91089bccf593e57ed3016b2f3
http://europepmc.org/articles/PMC5238624
http://europepmc.org/articles/PMC5238624
Autor:
Jesus M. Aizpurua, José I. Miranda, Maialen Sagartzazu-Aizpurua, Yuri Reyes, Zaira Monasterio
Publikováno v:
Organic Letters. 18:788-791
4-Alkynyl-1,2,3-triazolium cations undergo thermal [3 + 2] cycloaddition reactions with azides roughly 50- to 100-fold faster than comparable noncharged alkynes. Further, the reaction is highly 1,4-regioselective (dr up to 99:1) owing to the selectiv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0336e91a9e67f76901247236ff0d3100
https://doi.org/10.1021/acs.orglett.6b00055
https://doi.org/10.1021/acs.orglett.6b00055
Autor:
María del Puerto Morales, Luis Lezama, Maite Eceiza, Maialen Sagartzazu-Aizpurua, Maite Insausti, Izaskun Gil de Muro, Raluca M. Fratila, Rocío Costa, Eneko Garaio, Jesús M. de la Fuente, Oihane K. Arriortua, Jesus M. Aizpurua
Publikováno v:
Zaguán. Repositorio Digital de la Universidad de Zaragoza
instname
Digital.CSIC. Repositorio Institucional del CSIC
instname
Digital.CSIC. Repositorio Institucional del CSIC
To improve the selectivity of magnetic nanoparticles for tumor treatment by hyperthermia, Fe3O4 nanoparticles have been functionalized with a peptide of the type arginine-glycine-aspartate (RGD) following a "click" chemistry approach. The RGD peptide
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a828fd2140e7afe5eafdde67412301f
http://hdl.handle.net/10261/181288
http://hdl.handle.net/10261/181288
Autor:
Oihane K, Arriortua, Maite, Insausti, Luis, Lezama, Izaskun, Gil de Muro, Eneko, Garaio, Jesus Martínez, de la Fuente, Raluca M, Fratila, Maria P, Morales, Rocío, Costa, Maite, Eceiza, Maialen, Sagartzazu-Aizpurua, Jesus M, Aizpurua
Publikováno v:
Colloids and surfaces. B, Biointerfaces. 165
To improve the selectivity of magnetic nanoparticles for tumor treatment by hyperthermia, Fe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::b571bb947887b97921dc7a2034d355c2
https://pubmed.ncbi.nlm.nih.gov/29501962
https://pubmed.ncbi.nlm.nih.gov/29501962
Autor:
Marcos Navascuez, José I. Miranda, Jesus M. Aizpurua, Javier Idiago-López, Jesús M. de la Fuente, Raluca M. Fratila, Maite Eceiza
Publikováno v:
New J. Chem.
Zaguán. Repositorio Digital de la Universidad de Zaragoza
instname
Digital.CSIC. Repositorio Institucional del CSIC
Zaguán. Repositorio Digital de la Universidad de Zaragoza
instname
Digital.CSIC. Repositorio Institucional del CSIC
Herein we report the synthesis of “clickable” magnetic nanoparticles (MNPs) stable in suspension in physiological media for bioorthogonal click chemistry applications. These MNPs incorporate into their coating a cyclooctynyl derivative for strain
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd815fbe39aeac1a6891276db820f6b9
http://hdl.handle.net/10261/181851
http://hdl.handle.net/10261/181851
Autor:
Nerea Perez‐Esnaola, Raluca M. Fratila, Elena Andreieff, Zaira Monasterio, Jesus M. Aizpurua, Aitziber Irastorza, Maialen Sagartzazu-Aizpurua
Publikováno v:
New J. Chem.. 38:474-480
Accessing 1,2,3-triazole compounds through the copper-catalysed azide–alkyne “click” cycloaddition reaction is now a routine synthetic tool which has resulted in a huge amount of novel molecules of varied complexity bearing such heterocycles. 3
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::878303fcd12d38c08e8a10a5b04469d4
https://doi.org/10.1039/c3nj00667k
https://doi.org/10.1039/c3nj00667k
Autor:
Mohamed Zakaria Slimani, Assia Keniche, Joseph Kajima Mulengi, Jesus M. Aizpurua, José I. Miranda
Publikováno v:
Mediterranean Journal of Chemistry, Vol 2, Iss 5, Pp 620-631 (2014)
 Aziridines are known to undergo hydrolysis in the presence of cyclodextrins, whereas the latter are largely investigated as potential vectors of biologically active compounds. Despite this easy cyclodextrin-induced cleavage of aziridines in aqueou
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3cf15af7673cc3fcb04ad75f5bfeee7e
https://doi.org/10.13171/mjc.2.4.2013.01.12.11
https://doi.org/10.13171/mjc.2.4.2013.01.12.11
Autor:
José I. Miranda, Jesus M. Aizpurua, J. Ignacio Santos, Maialen Sagartzazu-Aizpurua, Itxaso Azcune, Eva Balentová, Raluca M. Fratila
Publikováno v:
European Journal of Organic Chemistry. 2013:2434-2444
The synthesis of three families of sialyl LewisX (sLeX) mimetics based on triazole and bis-triazole scaffolds is reported. The flexibility of these mimetics is dictated by the scaffold and gradually increases from flexible to rigid. All three familie
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b17e7ccfeeebc5abcad7a3721419fcd4
https://doi.org/10.1002/ejoc.201201674
https://doi.org/10.1002/ejoc.201201674