Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Jesus Lacal"'
Autor:
Sheila González-Salvatierra, Cristina García-Fontana, Jesus Lacal, Francisco Andújar-Vera, Luis Martínez-Heredia, Raquel Sanabria-de la Torre, María Ferrer-Millán, Enrique Moratalla-Aranda, Manuel Muñoz-Torres, Beatriz García-Fontana
Publikováno v:
Cardiovascular Diabetology, Vol 22, Iss 1, Pp 1-20 (2023)
Abstract Background Sclerostin is an inhibitor of the Wnt/b-catenin pathway, which regulates bone formation, and can be expressed in vascular smooth muscle cells (VSMCs). Type 2 diabetes (T2D) is associated with an increased risk of cardiovascular di
Externí odkaz:
https://doaj.org/article/89c488bf17db4b2f997788a443cc6bff
Autor:
Noemi Ferrito, Juan Báez-Flores, Mario Rodríguez-Martín, Julián Sastre-Rodríguez, Alessio Coppola, María Isidoro-García, Pablo Prieto-Matos, Jesus Lacal
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 16, p 8563 (2024)
RASopathies are a group of related genetic disorders caused by mutations in genes within the RAS/MAPK signaling pathway. This pathway is crucial for cell division, growth, and differentiation, and its disruption can lead to a variety of developmental
Externí odkaz:
https://doaj.org/article/77a15fd02540400c99f020faeb01582e
Publikováno v:
Communications Biology, Vol 6, Iss 1, Pp 1-13 (2023)
Abstract Neurofibromin controls many cell processes, such as growth, learning, and memory. If neurofibromin is not working properly, it can lead to health problems, including issues with the nervous, skeletal, and cardiovascular systems and cancer. T
Externí odkaz:
https://doaj.org/article/09eb800d8a334d53ad86db333b2532b5
Autor:
Mario Rodríguez-Martín, Juan Báez-Flores, Vanessa Ribes, María Isidoro-García, Jesus Lacal, Pablo Prieto-Matos
Publikováno v:
Biomedicines, Vol 12, Iss 4, p 841 (2024)
RASopathies, a group of neurodevelopmental congenital disorders stemming from mutations in the RAS/MAPK pathway, present a unique opportunity to delve into the intricacies of complex neurological disorders. Afflicting approximately one in a thousand
Externí odkaz:
https://doaj.org/article/4c8aa995b5554e85b9935a3d60f683db
Publikováno v:
Orphanet Journal of Rare Diseases, Vol 16, Iss 1, Pp 1-17 (2021)
Abstract Background RASopathies are a group of syndromes showing clinical overlap caused by mutations in genes affecting the RAS-MAPK pathway. Consequent disruption on cellular signaling leads and is driven by phosphoproteome remodeling. However, we
Externí odkaz:
https://doaj.org/article/c12e4fcf2bed471a8c101c44342df7bf
Publikováno v:
Microbial Biotechnology, Vol 14, Iss 1, Pp 111-125 (2021)
Summary Dictyostelium discoideum is one of eight non‐mammalian model organisms recognized by the National Institute of Health for the study of human pathology. The use of this slime mould is possible owing to similarities in cell structure, behavio
Externí odkaz:
https://doaj.org/article/2f06ab08555846dbbf0607531ece7704
Publikováno v:
Biomedicines, Vol 10, Iss 8, p 2044 (2022)
Neurofibromin is engaged in many cellular processes and when the proper protein functioning is impaired, it causes neurofibromatosis type 1 (NF1), one of the most common inherited neurological disorders. Recent advances in sequencing and screening of
Externí odkaz:
https://doaj.org/article/993d3950cbe54ae4801abac28388f791
Publikováno v:
Cells, Vol 8, Iss 10, p 1187 (2019)
Cyclic AMP acts as a secondary messenger involving different cellular functions in eukaryotes. Here, proteomic and transcriptomic profiling has been combined to identify novel early developmentally regulated proteins in eukaryote cells. These proteom
Externí odkaz:
https://doaj.org/article/0362898c9e194de1bf09704d63c3c523
Autor:
Zhouxin Shen, Jing Wei, Richard A. Firtel, Kimberly Baumgardner, Steven P. Briggs, Jesus Lacal Romero
Publikováno v:
Developmental biology. 435(1)
GSK3 plays a central role in orchestrating key biological signaling pathways, including cell migration. Here, we identify GlkA as a GSK3 family kinase with functions that overlap with and are distinct from those of GskA. We show that GlkA, as previou
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1260f4cec5f8520910902369b6daddfc
https://pubmed.ncbi.nlm.nih.gov/29355521
https://pubmed.ncbi.nlm.nih.gov/29355521
Autor:
Katarzyna Plak, Steven P. Briggs, Arjan Kortholt, Verena Kölsch, Jesus Lacal Romero, Susan Lee, Pouya Lotfi, Richard A. Firtel, Pascale G. Charest, Taeck J. Jeon, Zhouxin Shen, Jessica Chang
Publikováno v:
Molecular Biology of the Cell
Molecular Biology of the Cell, 24(2), 100-114. AMER SOC CELL BIOLOGY
Molecular Biology of the Cell, 24(2), 100-114. AMER SOC CELL BIOLOGY
Daydreamer (DydA), a new Mig10/RIAM/lamellipodin family adaptor protein, is a Ras effector required for cell polarization and directional movement during chemotaxis. DydA is phosphorylated by glycogen synthase kinase-3, which is required for some, bu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c945b6be433c20f6b6fcd4f1c5147a0
http://acikerisim.sdu.edu.tr/xmlui/handle/123456789/98533
http://acikerisim.sdu.edu.tr/xmlui/handle/123456789/98533
