Mechanism of bisphosphonate-related osteonecrosis of the jaw (BRONJ) revealed by targeted removal of legacy bisphosphonate from jawbone using competing inert hydroxymethylene diphosphonate

Autor: Hiroko Okawa, Takeru Kondo, Akishige Hokugo, Philip Cherian, Jesus J Campagna, Nicholas A Lentini, Eric C Sung, Samantha Chiang, Yi-Ling Lin, Frank H Ebetino, Varghese John, Shuting Sun, Charles E McKenna, Ichiro Nishimura

Publikováno v: eLife, Vol 11 (2022)

Bisphosphonate-related osteonecrosis of the jaw (BRONJ) presents as a morbid jawbone lesion in patients exposed to a nitrogen-containing bisphosphonate (N-BP). Although it is rare, BRONJ has caused apprehension among patients and healthcare providers

Externí odkaz: https://doaj.org/article/e3ceccf5a73f432bb37f38fa3f67e062

Author response: Mechanism of bisphosphonate-related osteonecrosis of the jaw (BRONJ) revealed by targeted removal of legacy bisphosphonate from jawbone using competing inert hydroxymethylene diphosphonate

Autor: Takeru Kondo, Hiroko Okawa, Akishige Hokugo, Philip Cherian, Jesus J Campagna, Nicholas A Lentini, Eric C Sung, Samantha Chiang, Yi-Ling Lin, Frank H Ebetino, Varghese John, Shuting Sun, Charles E McKenna, Ichiro Nishimura

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::273f03c67bf842227ff70c0a2cc627cc
https://doi.org/10.7554/elife.76207.sa2

Integrated Multiomics Analysis of Salivary Exosomes to Identify Biomarkers Associated with Changes in Mood States and Fatigue.

Autor: Cohn W; The Drug Discovery Lab, Department of Neurology, David Geffen School of Medicine, 710 Westwood Plaza, University of California Los Angeles, Los Angeles, CA 90095, USA., Zhu C; The Drug Discovery Lab, Department of Neurology, David Geffen School of Medicine, 710 Westwood Plaza, University of California Los Angeles, Los Angeles, CA 90095, USA., Campagna J; The Drug Discovery Lab, Department of Neurology, David Geffen School of Medicine, 710 Westwood Plaza, University of California Los Angeles, Los Angeles, CA 90095, USA., Bilousova T; The Drug Discovery Lab, Department of Neurology, David Geffen School of Medicine, 710 Westwood Plaza, University of California Los Angeles, Los Angeles, CA 90095, USA., Spilman P; The Drug Discovery Lab, Department of Neurology, David Geffen School of Medicine, 710 Westwood Plaza, University of California Los Angeles, Los Angeles, CA 90095, USA., Teter B; The Drug Discovery Lab, Department of Neurology, David Geffen School of Medicine, 710 Westwood Plaza, University of California Los Angeles, Los Angeles, CA 90095, USA., Li F; Center for Oral/Head & Neck Oncology Research, Laboratory of Salivary Diagnostics, School of Dentistry, 10833 Le Conte Avenue, University of California Los Angeles, Los Angeles, CA 90095, USA., Guo R; Department of Medicine Statistics Core, David Geffen School of Medicine, 1100 Glendon Avenue, University of California Los Angeles, Los Angeles, CA 90095, USA., Elashoff D; Department of Medicine Statistics Core, David Geffen School of Medicine, 1100 Glendon Avenue, University of California Los Angeles, Los Angeles, CA 90095, USA., Cole GM; Department of Neurology, David Geffen School of Medicine, 710 Westwood Plaza, University of California Los Angeles, Los Angeles, CA 90095, USA., Avidan A; Department of Neurology, David Geffen School of Medicine, 710 Westwood Plaza, University of California Los Angeles, Los Angeles, CA 90095, USA., Faull KF; Pasarow Mass Spectrometry Laboratory, Jane and Terry Semel Institute for Neuroscience and Human Behavior, David Geffen School of Medicine, 760 Westwood Plaza, University of California Los Angeles, Los Angeles, CA 90095, USA., Whitelegge J; Pasarow Mass Spectrometry Laboratory, Jane and Terry Semel Institute for Neuroscience and Human Behavior, David Geffen School of Medicine, 760 Westwood Plaza, University of California Los Angeles, Los Angeles, CA 90095, USA., Wong DTW; Center for Oral/Head & Neck Oncology Research, Laboratory of Salivary Diagnostics, School of Dentistry, 10833 Le Conte Avenue, University of California Los Angeles, Los Angeles, CA 90095, USA., John V; The Drug Discovery Lab, Department of Neurology, David Geffen School of Medicine, 710 Westwood Plaza, University of California Los Angeles, Los Angeles, CA 90095, USA.

Publikováno v: International journal of molecular sciences [Int J Mol Sci] 2022 May 09; Vol. 23 (9). Date of Electronic Publication: 2022 May 09.

Pharmacological inhibition of nSMase2 reduces brain exosome release and α-synuclein pathology in a Parkinson's disease model.

Autor: Zhu C; Drug Discovery Lab, Department of Neurology, University of California, Los Angeles, CA, 90095, USA., Bilousova T; Drug Discovery Lab, Department of Neurology, University of California, Los Angeles, CA, 90095, USA.; School of Nursing, University of California, Los Angeles, CA, 90095, USA., Focht S; Drug Discovery Lab, Department of Neurology, University of California, Los Angeles, CA, 90095, USA., Jun M; Drug Discovery Lab, Department of Neurology, University of California, Los Angeles, CA, 90095, USA., Elias CJ; Drug Discovery Lab, Department of Neurology, University of California, Los Angeles, CA, 90095, USA., Melnik M; Drug Discovery Lab, Department of Neurology, University of California, Los Angeles, CA, 90095, USA., Chandra S; Drug Discovery Lab, Department of Neurology, University of California, Los Angeles, CA, 90095, USA., Campagna J; Drug Discovery Lab, Department of Neurology, University of California, Los Angeles, CA, 90095, USA., Cohn W; Drug Discovery Lab, Department of Neurology, University of California, Los Angeles, CA, 90095, USA., Hatami A; Drug Discovery Lab, Department of Neurology, University of California, Los Angeles, CA, 90095, USA., Spilman P; Drug Discovery Lab, Department of Neurology, University of California, Los Angeles, CA, 90095, USA., Gylys KH; School of Nursing, University of California, Los Angeles, CA, 90095, USA., John V; Drug Discovery Lab, Department of Neurology, University of California, Los Angeles, CA, 90095, USA. VJohn@mednet.ucla.edu.

Publikováno v: Molecular brain [Mol Brain] 2021 Apr 19; Vol. 14 (1), pp. 70. Date of Electronic Publication: 2021 Apr 19.

High-throughput screening identifies modulators of sarcospan that stabilize muscle cells and exhibit activity in the mouse model of Duchenne muscular dystrophy.

Autor: Shu C; Molecular Biology Institute, University of California Los Angeles, Los Angeles, CA, USA.; Department of Integrative Biology and Physiology, University of California Los Angeles, 610 Charles E. Young Drive East, Terasaki Life Sciences Building, Los Angeles, CA, 90095, USA.; Center for Duchenne Muscular Dystrophy, University of California Los Angeles, Los Angeles, CA, USA., Parfenova L; Department of Integrative Biology and Physiology, University of California Los Angeles, 610 Charles E. Young Drive East, Terasaki Life Sciences Building, Los Angeles, CA, 90095, USA., Mokhonova E; Department of Integrative Biology and Physiology, University of California Los Angeles, 610 Charles E. Young Drive East, Terasaki Life Sciences Building, Los Angeles, CA, 90095, USA.; Center for Duchenne Muscular Dystrophy, University of California Los Angeles, Los Angeles, CA, USA., Collado JR; Department of Integrative Biology and Physiology, University of California Los Angeles, 610 Charles E. Young Drive East, Terasaki Life Sciences Building, Los Angeles, CA, 90095, USA., Damoiseaux R; Department of Molecular and Medicinal Pharmacology, University of California Los Angeles, Los Angeles, CA, USA.; California NanoSystems Institute, University of California Los Angeles, Los Angeles, CA, USA., Campagna J; Department of Neurology, David Geffen School of Medicine, University of California Los Angeles, 610 Charles E. Young Drive East, Terasaki Life Sciences Building, Los Angeles, CA, 90095, USA.; Drug Discovery Lab, University of California Los Angeles, Los Angeles, CA, USA., John V; Department of Neurology, David Geffen School of Medicine, University of California Los Angeles, 610 Charles E. Young Drive East, Terasaki Life Sciences Building, Los Angeles, CA, 90095, USA.; Drug Discovery Lab, University of California Los Angeles, Los Angeles, CA, USA., Crosbie RH; Molecular Biology Institute, University of California Los Angeles, Los Angeles, CA, USA. rcrosbie@physci.ucla.edu.; Department of Integrative Biology and Physiology, University of California Los Angeles, 610 Charles E. Young Drive East, Terasaki Life Sciences Building, Los Angeles, CA, 90095, USA. rcrosbie@physci.ucla.edu.; Center for Duchenne Muscular Dystrophy, University of California Los Angeles, Los Angeles, CA, USA. rcrosbie@physci.ucla.edu.; Department of Neurology, David Geffen School of Medicine, University of California Los Angeles, 610 Charles E. Young Drive East, Terasaki Life Sciences Building, Los Angeles, CA, 90095, USA. rcrosbie@physci.ucla.edu.

Publikováno v: Skeletal muscle [Skelet Muscle] 2020 Sep 18; Vol. 10 (1), pp. 26. Date of Electronic Publication: 2020 Sep 18.