Výsledky vyhledávání - "Jesus I. Luna"

Akademický článek

Radiotherapy enhances natural killer cell cytotoxicity and localization in pre-clinical canine sarcomas and first-in-dog clinical trial

Autor: Robert J. Canter, Steven K. Grossenbacher, Jennifer A. Foltz, Ian R. Sturgill, Jiwon S. Park, Jesus I. Luna, Michael S. Kent, William T. N. Culp, Mingyi Chen, Jaime F. Modiano, Arta M. Monjazeb, Dean A. Lee, William J. Murphy

Publikováno v: Journal for ImmunoTherapy of Cancer, Vol 5, Iss 1, Pp 1-16 (2017)

Abstract Background We have previously shown that radiotherapy (RT) augments natural killer (NK) functions in pre-clinical models of human and mouse cancers, including sarcomas. Since dogs are an excellent outbred model for immunotherapy studies, we

Externí odkaz: https://doaj.org/article/d9d90a18101e43b28f38e4ccfff5995e

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Akademický článek

Canine cancer immunotherapy studies: linking mouse and human

Autor: William J. Murphy, Robert J. Canter, Jesus I. Luna, Mingyi Chen, Michael S. Kent, Jiwon S. Park, Sita S. Withers, Jaime F. Modiano, Ellen E. Sparger, Robert B. Rebhun, Arta M. Monjazeb

Publikováno v: Journal for ImmunoTherapy of Cancer, Vol 4, Iss 1 (2016)

Despite recent major clinical breakthroughs in human cancer immunotherapy including the use of checkpoint inhibitors and engineered T cells, important challenges remain, including determining the sub-populations of patients who will respond and who w

Externí odkaz: https://doaj.org/article/a6f1431ec5084fa9bcd705c3a6405183

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Obesity induces gut microbiota alterations and augments acute graft-versus-host disease after allogeneic stem cell transplantation

Publikováno v: Sci Transl Med

The efficacy of allogeneic hematopoietic stem cell transplantation (allo-HSCT) is limited by acute and chronic graft-versus-host disease (GVHD). The impact of obesity on allo-HSCT outcomes is poorly understood. Here, we report that obesity had a nega

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4cb2199cfd87077393f6d422bccc5a49
https://doi.org/10.1126/scitranslmed.aay7713

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Paradoxical effects of obesity on T cell function during tumor progression and PD-1 checkpoint blockade

Publikováno v: Nature Medicine. 25:141-151

The recent successes of immunotherapy have shifted the paradigm in cancer treatment, but because only a percentage of patients are responsive to immunotherapy, it is imperative to identify factors impacting outcome. Obesity is reaching pandemic propo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::34760490f22ca816d2c386561379d71c
https://doi.org/10.1038/s41591-018-0221-5

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Tuning microenvironment modulus and biochemical composition promotes human mesenchymal stem cell tenogenic differentiation

Autor: Emanual Michael Maverakis, April M. Kloxin, Matthew S. Rehmann, Jesus I. Luna

Publikováno v: Journal of Biomedical Materials Research Part A. 104:1162-1174

Mesenchymal stem cells (MSCs) are promising for the regeneration of tendon and ligament tissues. Toward realizing this potential, microenvironment conditions are needed for promoting robust lineage-specific differentiation into tenocytes/ligament fib

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::bc5bb22c08fe3259b91e9e49e1e9e84d
https://doi.org/10.1002/jbm.a.35650

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Tunable hydrogels for mesenchymal stem cell delivery: Integrin-induced transcriptome alterations and hydrogel optimization for human wound healing

Publikováno v: Stem cells (Dayton, Ohio)REFERENCES. 38(2)

Therapeutic applications for mesenchymal stem/stromal cells (MSCs) are growing; however, the successful implementation of these therapies requires the development of appropriate MSC delivery systems. Hydrogels are ideally suited to cultivate MSCs but

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82ab3cf023248bdebd2982d7a62789cc
https://pubmed.ncbi.nlm.nih.gov/31648388

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Radiotherapy enhances natural killer cell cytotoxicity and localization in pre-clinical canine sarcomas and first-in-dog clinical trial

Autor: Jesus I. Luna, Arta M. Monjazeb, Jennifer A. Foltz, Steven K. Grossenbacher, Robert J. Canter, William T. N. Culp, Dean A. Lee, Ian R. Sturgill, Michael S. Kent, Mingyi Chen, William J. Murphy, Jaime F. Modiano, Jiwon Sarah Park

Publikováno v: Journal for immunotherapy of cancer, vol 5, iss 1
Journal for Immunotherapy of Cancer
Canter, RJ; Grossenbacher, SK; Foltz, JA; Sturgill, IR; Park, JS; Luna, JI; et al.(2017). Radiotherapy enhances natural killer cell cytotoxicity and localization in pre-clinical canine sarcomas and first-in-dog clinical trial. Journal for ImmunoTherapy of Cancer, 5(1). doi: 10.1186/s40425-017-0305-7. UC Davis: Retrieved from: http://www.escholarship.org/uc/item/0hj110cn
Journal for ImmunoTherapy of Cancer, Vol 5, Iss 1, Pp 1-16 (2017)

Background We have previously shown that radiotherapy (RT) augments natural killer (NK) functions in pre-clinical models of human and mouse cancers, including sarcomas. Since dogs are an excellent outbred model for immunotherapy studies, we sought to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8eb8e896b690c95a23a180269378e4ba
https://escholarship.org/uc/item/0hj110cn

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Dual mTOR Inhibition Is Required to Prevent TGF-β-Mediated Fibrosis: Implications for Scleroderma

Autor: Alexander A. Merleev, Siba P. Raychaudhuri, Emanual Michael Maverakis, David Fiorentino, Jesus I. Luna, Alina I. Marusina, Anupam Mitra, Smriti Kundu-Raychaudhuri

Publikováno v: The Journal of Investigative Dermatology

TO THE EDITOR Transforming growth factor-β (TGF-β) and platelet-derived growth factor (PDGF) are central mediators of fibrosis, and their overexpression contributes to the pathophysiology of scleroderma, chiefly by inducing the overproduction of ex

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64d8c437e266cb285b3eae0aa68edcb4
http://europepmc.org/articles/PMC4640976

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ITK inhibition for the targeted treatment of CTCL

Autor: Elizabeth A. Wang, Alexander A. Merleev, Emanual Michael Maverakis, Itzel Bustos-Villalobos, Wenchang Guo, Anupam Mitra, Hawa Sultani, Gaurav Bhardwaj, Alina I. Marusina, Jesus I. Luna, Jennifer Williams Bergstrom, Andrea Sukhov, Hsing Jien Kung, Nathan E. Haigh, Ruiwu Liu, Kit S. Lam

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1d54b0ef7aa728ee888da79ee96c757
https://europepmc.org/articles/PMC6459605/

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Targeting Cancer Stem Cells with Natural Killer Cell Immunotherapy

Autor: William J. Murphy, Robert J. Canter, Steven K. Grossenbacher, Jesus I. Luna

Publikováno v: Expert opinion on biological therapy, vol 17, iss 3
Luna, JI; Grossenbacher, SK; Murphy, WJ; & Canter, RJ. (2017). Targeting Cancer Stem Cells with Natural Killer Cell Immunotherapy. Expert Opinion on Biological Therapy, 17(3), 313-324. doi: 10.1080/14712598.2017.1271874. UC Davis: Retrieved from: http://www.escholarship.org/uc/item/7bb9k7zj

© 2016 Informa UK Limited, trading as Taylor & Francis Group. Introduction: Standard cytoreductive cancer therapy, such as chemotherapy and radiotherapy, are frequently resisted by a small portion of cancer cells with ‘stem-cell’ like properties

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe4d2730c1ecd00314ea14a9d7206226
https://escholarship.org/uc/item/7bb9k7zj

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