Exposure to hypergravity during zebrafish development alters cartilage material properties and strain distribution

Autor: Chrissy L. Hammond, Niamh C. Nowlan, Jack J. W. A. van Loon, Josepha Godivier, Jessye A. Aggleton, Elizabeth A. Lawrence, Robert L. Harniman, Jiaxin Pei

Publikováno v: Bone & Joint Research, Vol 10, Iss 2, Pp 137-148 (2021)
Bone Joint Res
Bone and Joint Research, 10(2), 137-148. British Editorial Society of Bone and Joint Surgery
Lawrence, E A, Pei, J, Hammond, C, Aggleton, J, van Loon, J, Godivier, J, Nowlan, N & Harniman, R 2021, ' Exposure to hypergravity during zebrafish development alters cartilage material properties and strain distribution ', Bone and Joint Research, vol. 10, no. 2, pp. 137-148 . https://doi.org/10.1302/2046-3758.102.BJR-2020-0239.R1
Lawrence, E A, Aggleton, J, van Loon, J, Godivier, J, Harniman, R L, Pei, J, Nowlan, N & Hammond, C 2021, ' Exposure to hypergravity during zebrafish development alters cartilage material properties and strain distribution. ', Bone and Joint Research, vol. 10, no. 2, pp. 137–148 . https://doi.org/10.1302/2046-3758.102.BJR-2020-0239.R1

Aims Vertebrates have adapted to life on Earth and its constant gravitational field, which exerts load on the body and influences the structure and function of tissues. While the effects of microgravity on muscle and bone homeostasis are well describ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::63cdec30405e3443f514f8703a4c9f42
https://doi.org/10.1302/2046-3758.102.bjr-2020-0239.r1

Species-specific sensitivity to TGFβ signaling and changes to the Mmp13 promoter underlie avian jaw development and evolution

Autor: Spenser S Smith, Daniel Chu, Tiange Qu, Jessye A Aggleton, Richard A Schneider

Publikováno v: eLife. 11

Precise developmental control of jaw length is critical for survival, but underlying molecular mechanisms remain poorly understood. The jaw skeleton arises from neural crest mesenchyme (NCM), and we previously demonstrated that these progenitor cells

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6c09fc452906379c7c13945c15eb04e
https://pubmed.ncbi.nlm.nih.gov/35666955

The mechanical impact of

Autor: Elizabeth A, Lawrence, Erika, Kague, Jessye A, Aggleton, Robert L, Harniman, Karen A, Roddy, Chrissy L, Hammond

Publikováno v: Philosophical transactions of the Royal Society of London. Series B, Biological sciences. 373(1759)

Collagen is the major structural component of cartilage, and mutations in the genes encoding type XI collagen are associated with severe skeletal dysplasias (fibrochondrogenesis and Stickler syndrome) and early-onset osteoarthritis (OA). The impact o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::9c594e5b59043832cbb702f964a5da62
https://pubmed.ncbi.nlm.nih.gov/30249781