Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Jesslyn E, Park"'
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-9 (2021)
Stochastic fluctuations at the transcriptional level contribute to heterogeneity in isogenic cell populations. Here, the authors engineer TuNR which modulates the variability in gene expression of endogenous human genes independent of their mean expr
Externí odkaz:
https://doaj.org/article/40c72744eec947a8be9ff201dea8efdf
Autor:
Alexandra M, Amen, Christof, Fellmann, Katarzyna M, Soczek, Shawn M, Ren, Rachel J, Lew, Gavin J, Knott, Jesslyn E, Park, Andrew M, McKinney, Andrew, Mancini, Jennifer A, Doudna, Joseph F, Costello
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance Glioblastoma is a highly lethal form of brain cancer with no current treatment options that substantially improve patient outcomes. A key therapeutic challenge is the identification of methods that reduce tumor burden while leaving norma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::2e48ad2ec993b0fb3f763a1e03d0cf22
https://pubmed.ncbi.nlm.nih.gov/33758097
https://pubmed.ncbi.nlm.nih.gov/33758097
Autor:
Andrew McKinney, Christof Fellmann, Katarzyna M. Soczek, Jennifer A. Doudna, Gavin J. Knott, Rachel J. Lew, Joseph F. Costello, Jesslyn E. Park, Shawn M. Ren, Andrew Mancini, Alexandra M. Amen
Publikováno v:
Proceedings of the National Academy of Sciences. 118
Most glioblastomas (GBMs) achieve cellular immortality by acquiring a mutation in the telomerase reverse transcriptase (TERT) promoter. TERT promoter mutations create a binding site for a GA binding protein (GABP) transcription factor complex, whose
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::edbadbc20c27bba3bef4a0caf93b1e34
https://doi.org/10.1073/pnas.2008772118
https://doi.org/10.1073/pnas.2008772118
Autor:
Issa Yousif, Vicki H. Wysocki, Nicholas B. Woodall, David Baker, Richard S. Johnson, Michael E. P. Murphy, Florian Busch, Jesslyn E Park, Zara Y. Weinberg, Maggie Ahlrichs, Hana El-Samad, Michael J. MacCoss, Mikayla J Feldbauer
Publikováno v:
Nat Struct Mol Biol
Kinases play central roles in signaling cascades, relaying information from the outside to the inside of mammalian cells. De novo designed protein switches capable of interfacing with tyrosine kinase signaling pathways would open new avenues for cont
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::45df16d22a4b92fb0aeb29e3524629eb
https://pubmed.ncbi.nlm.nih.gov/34518698
https://pubmed.ncbi.nlm.nih.gov/34518698
Autor:
Ian B. Seiple, Arthur A Tran, Justin T Biel, Dean L. Shinabarger, Beverly Murray, David Chow, Na Zhang, Kenneth W. Borrelli, Kaijie Ji, Gydo C. P. van Zundert, Jenna Pellegrino, D. John Lee, Cindy Wolfe, Jesslyn E Park, Ruoxi Wang, Qi Li, Olivier Chesneau, Estelle Mühle, Axel F. Brilot, Hector A Chaires, Matthew P. Jacobson, James S. Fraser
Publikováno v:
Nature
Nature, 2020, 586 (7827), pp.145-150. ⟨10.1038/s41586-020-2761-3⟩
Nature, vol 586, iss 7827
Nature, Nature Publishing Group, 2020, 586 (7827), pp.145-150. ⟨10.1038/s41586-020-2761-3⟩
Nature, 2020, 586 (7827), pp.145-150. ⟨10.1038/s41586-020-2761-3⟩
Nature, vol 586, iss 7827
Nature, Nature Publishing Group, 2020, 586 (7827), pp.145-150. ⟨10.1038/s41586-020-2761-3⟩
International audience; Natural products serve as chemical blueprints for most antibiotics in clinical use. The evolutionary process by which these molecules arise is inherently accompanied by the co-evolution of resistance mechanisms that shorten th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43735642a3593a0038eaf47b71d6765a
https://hal-pasteur.archives-ouvertes.fr/pasteur-03082400
https://hal-pasteur.archives-ouvertes.fr/pasteur-03082400
Stochastic fluctuations at the transcriptional level contribute to isogenic cell-to-cell heterogeneity in mammalian cell populations. However, we still have no clear understanding of the repercussions of this heterogeneity, given the lack of tools to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a4db15fdbb62d7d42c9834f4170488cc
https://doi.org/10.1101/2020.05.23.112979
https://doi.org/10.1101/2020.05.23.112979
Autor:
Christof Fellmann, Joseph F. Costello, Andrew McKinney, Alexandra M. Amen, Andrew Mancini, Gavin J. Knott, Rachel J. Lew, Shawn M. Ren, Jesslyn E. Park, Katarzyna M. Soczek, Jennifer A. Doudna
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America, vol 118, iss 13
Most glioblastomas (GBMs) achieve cellular immortality by acquiring a mutation in the telomerase reverse transcriptase (TERT) promoter. TERT promoter mutations create a binding site for a GA binding protein (GABP) transcription factor complex, whose
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c9a472cc8b42a7d114da1be5e2d57934
https://doi.org/10.1101/2020.04.25.061606
https://doi.org/10.1101/2020.04.25.061606
Autor:
Beverly Murray, David Chow, Kaijie Ji, Justin T Biel, Jesslyn E Park, Axel F. Brilot, Jenna Pellegrino, James S. Fraser, Gydo C. P. van Zundert, Dean L. Shinabarger, Matthew P. Jacobson, Kenneth W. Borrelli, Cindy Wolfe, Ian B. Seiple, Arthur A Tran, Qi Li, D. John Lee, Na Zhang, Ruoxi Wang
Natural products serve as chemical blueprints for the majority of classes of antibiotics in our clinical arsenal. The evolutionary process by which these molecules arise is inherently accompanied by the co-evolution of resistance mechanisms that shor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bc2f3c3b49dce094c6c8465b797465fc
https://doi.org/10.26434/chemrxiv.8346107.v2
https://doi.org/10.26434/chemrxiv.8346107.v2