Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Jessika, Klöckner"'
Autor:
Ulrike Zabel, Carsten Hoffmann, Jessika Klöckner, Susanne Nuber, Michael Kauk, Regina Messerer, Maria Consuelo Alonso Canizal, Daniela Volpato, Ulrike Holzgrabe
Publikováno v:
ACS Chemical Biology. 12:833-843
Aiming to design partial agonists as well as allosteric modulators for the M1 muscarinic acetylcholine (M1AChR) receptor, two different series of bipharmacophoric ligands and their structural analogues were designed and synthesized. The hybrids were
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d4d2fb6fd669960d0cf18f1b3cbbc4a2
https://doi.org/10.1021/acschembio.6b00828
https://doi.org/10.1021/acschembio.6b00828
Autor:
Regina, Messerer, Michael, Kauk, Daniela, Volpato, Maria Consuelo, Alonso Canizal, Jessika, Klöckner, Ulrike, Zabel, Susanne, Nuber, Carsten, Hoffmann, Ulrike, Holzgrabe
Publikováno v:
ACS chemical biology. 12(3)
Aiming to design partial agonists as well as allosteric modulators for the M
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::542ef3a06c366d7a0b6bd5560572964d
https://pubmed.ncbi.nlm.nih.gov/28117571
https://pubmed.ncbi.nlm.nih.gov/28117571
Autor:
Clelia Dallanoce, Evi Kostenis, Klaus Mohr, M. De Amici, Jessika Klöckner, Ulrike Holzgrabe, Wiebke K. Seemann, Ramona Schrage, Kurt Racké
Publikováno v:
British Journal of Pharmacology. 169:357-370
Background and Purpose Artificial agonists may have higher efficacy for receptor activation than the physiological agonist. Until now, such ‘superagonism’ has rarely been reported for GPCRs. Iperoxo is an extremely potent muscarinic receptor agon
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f88d4dfcb89638359ae6aea5103887fa
https://doi.org/10.1111/bph.12003
https://doi.org/10.1111/bph.12003
Autor:
Christian Tränkle, Jessika Klöckner, Klaus Mohr, Andreas Bock, Michael Decker, Wiebke K. Seemann, Cornelia Zimmermann, Ulrike Holzgrabe, Ramona Schrage, Janine Holze, Xinyu Chen
Publikováno v:
Journal of medicinal chemistry. 58(2)
Aiming to design partial agonists for a G-protein-coupled receptor based on dynamic ligand binding, we synthesized three different series of bipharmacophoric ligands composed of the orthosteric building blocks iperoxo and 1 linked to allosteric modul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ffabbcc87052d15bc98a2415d29d6ca
https://pubmed.ncbi.nlm.nih.gov/25478907
https://pubmed.ncbi.nlm.nih.gov/25478907