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Autor:
Alvin ST Lim, Tse Hui Lim, Su Keyau Kee, Patrick Chia, Subramaniam Raman, Elizabeth LP Eu, Jessie YC Lim, Sim Leng Tien
Publikováno v:
Annals of the Academy of Medicine, Singapore. 37:594-597
Introduction: Holoprosencephaly (HPE) is an uncommon congenital failure of forebrain development. Although the aetiology is heterogeneous, chromosomal abnormalities or a monogenic defect are the major causes, accounting for about 40% to 50% of HPE ca