Zobrazeno 1 - 10
of 39
pro vyhledávání: '"Jessie R. Lavoie"'
Autor:
Frederic St‐Denis‐Bissonnette, Shirley Qiu, Sarah E. Cummings, Melanie Kirkby, Yohannes Haile, Sarah Wassmer, Gauri Muradia, Jelica Mehic, Andrew Stalker, Amit Shrestha, Michele Ardolino, Seung‐Hwan Lee, Dylan Burger, Lisheng Wang, Jessie R. Lavoie
Publikováno v:
Journal of Extracellular Biology, Vol 3, Iss 7, Pp n/a-n/a (2024)
Abstract Natural killer cell‐derived extracellular vesicles (NK‐EVs) are candidate biotherapeutics against various cancers. However, standardised potency assays are necessary for a reliable assessment of NK‐EVs' cytotoxicity. This study aims to
Externí odkaz:
https://doaj.org/article/e9c74a4ae6444282ad687844f70ffab3
Autor:
Karan Mediratta, Sara El-Sahli, Marie Marotel, Muhammad Z. Awan, Melanie Kirkby, Ammar Salkini, Reem Kurdieh, Salman Abdisalam, Amit Shrestha, Chiara Di Censo, Andrew Sulaiman, Sarah McGarry, Jessie R. Lavoie, Zhen Liu, Seung-Hwan Lee, Xuguang Li, Giuseppe Sciumè, Vanessa M. D’Costa, Michele Ardolino, Lisheng Wang
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
IntroductionChemotherapy remains the mainstay treatment for triple-negative breast cancer (TNBC) due to the lack of specific targets. Given a modest response of immune checkpoint inhibitors in TNBC patients, improving immunotherapy is an urgent and c
Externí odkaz:
https://doaj.org/article/10213cd0c20d41adb4e2783bba54bf80
Autor:
Sarah E. Cummings, Sean P. Delaney, Frederic St-Denis Bissonnette, Andrew Stalker, Gauri Muradia, Jelica Mehic, Tyson E. Graber, Tommy Alain, Jessie R. Lavoie
Publikováno v:
iScience, Vol 27, Iss 1, Pp 108708- (2024)
Summary: Extracellular vesicles (EVs) are entering the clinical arena as novel biologics for infectious diseases, potentially serving as the immunogenic components of next generation vaccines. However, relevant human assays to evaluate the immunogeni
Externí odkaz:
https://doaj.org/article/46998e4c994a4f13a53d86c66f5bea2f
Autor:
Frederic St‐Denis‐Bissonnette, Sarah E. Cummings, Shirley Qiu, Andrew Stalker, Gauri Muradia, Jelica Mehic, Karan Mediratta, Shelby Kaczmarek, Dylan Burger, Seung‐Hwan Lee, Lisheng Wang, Jessie R. Lavoie
Publikováno v:
Journal of Extracellular Vesicles, Vol 12, Iss 12, Pp n/a-n/a (2023)
Abstract Natural killer cell‐derived extracellular vesicles (NK‐EVs) have shown promising potential as biotherapeutics for cancer due to their unique attributes as cytotoxic nanovesicles against cancer cells and immune‐modulatory activity towar
Externí odkaz:
https://doaj.org/article/1906ed4190454e6db53b02b8e2e4579a
Autor:
Jonathan Gobin, Gauri Muradia, Jelica Mehic, Carole Westwood, Lauren Couvrette, Andrew Stalker, Stewart Bigelow, Christian C. Luebbert, Frédéric St-Denis Bissonnette, Michael J. W. Johnston, Simon Sauvé, Roger Y. Tam, Lisheng Wang, Michael Rosu-Myles, Jessie R. Lavoie
Publikováno v:
Stem Cell Research & Therapy, Vol 12, Iss 1, Pp 1-20 (2021)
Abstract Background Extracellular vesicles (EVs) produced by human bone marrow-derived mesenchymal stromal cells (hBM-MSCs) are currently investigated for their clinical effectiveness towards immune-mediated diseases. The large amounts of stem cell-d
Externí odkaz:
https://doaj.org/article/a55f2bdc68d84265a2f18242fd0f7540
Autor:
Sathya N. Thulasi Raman, Elyse Latreille, Jun Gao, Wanyue Zhang, Jianguo Wu, Marsha S. Russell, Lisa Walrond, Terry Cyr, Jessie R. Lavoie, David Safronetz, Jingxin Cao, Simon Sauve, Aaron Farnsworth, Wangxue Chen, Pei-Yong Shi, Youchun Wang, Lisheng Wang, Michael Rosu-Myles, Xuguang Li
Publikováno v:
Emerging Microbes and Infections, Vol 9, Iss 1, Pp 2046-2060 (2020)
ABSTRACTZika virus (ZIKV) infection is a serious public threat with cases reported in about 70 countries and territories. One of the most serious consequences of ZIKV infection is congenital microcephaly in babies. Congenital microcephaly has been su
Externí odkaz:
https://doaj.org/article/fdad955415bd458c92d94ba2bdcf4fe1
Autor:
Afnan Munshi, Jelica Mehic, Marybeth Creskey, Jonathan Gobin, Jun Gao, Emma Rigg, Gauri Muradia, Christian C. Luebbert, Carole Westwood, Andrew Stalker, David S. Allan, Michael J. W. Johnston, Terry Cyr, Michael Rosu-Myles, Jessie R. Lavoie
Publikováno v:
Stem Cell Research & Therapy, Vol 10, Iss 1, Pp 1-18 (2019)
Abstract Background Clinical applications have shown extracellular vesicles (EVs) to be a major paracrine effector in therapeutic responses produced by human mesenchymal stromal/stem cells (hMSCs). As the regenerative capacity of EVs is mainly ascrib
Externí odkaz:
https://doaj.org/article/699ae8e7d7ea4864b8c63797fe386e89
Autor:
Rafael Diaz de la Guardia, Belen Lopez-Millan, Jessie R. Lavoie, Clara Bueno, Julio Castaño, Maite Gómez-Casares, Susana Vives, Laura Palomo, Manel Juan, Julio Delgado, Maria L. Blanco, Josep Nomdedeu, Alberto Chaparro, Jose Luis Fuster, Eduardo Anguita, Michael Rosu-Myles, Pablo Menéndez
Publikováno v:
Stem Cell Reports, Vol 8, Iss 6, Pp 1573-1586 (2017)
Bone marrow mesenchymal stem/stromal cells (BM-MSCs) are key components of the hematopoietic niche thought to have a direct role in leukemia pathogenesis. BM-MSCs from patients with acute myeloid leukemia (AML) have been poorly characterized due to d
Externí odkaz:
https://doaj.org/article/8a601ea5525044378fac7231bc7d668a
Autor:
Marsha S. Russell, Marybeth Creskey, Abenaya Muralidharan, Changgui Li, Jun Gao, Wangxue Chen, Louise Larocque, Jessie R. Lavoie, Aaron Farnsworth, Michael Rosu-Myles, Anwar M. Hashem, Carole L. Yauk, Jingxin Cao, Gary Van Domselaar, Terry Cyr, Xuguang Li
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
Respiratory syncytial virus (RSV) infection is a severe threat to young children and the elderly. Despite decades of research, no vaccine has been approved. Notably, instead of affording protection, a formalin-inactivated RSV vaccine induced severe r
Externí odkaz:
https://doaj.org/article/184618002a8343b39ce466d49b1559bc
Autor:
Winston Y. Cheung, Owen Hovey, Jonathan M. Gobin, Gauri Muradia, Jelica Mehic, Carole Westwood, Jessie R. Lavoie
Publikováno v:
Stem Cells International, Vol 2018 (2018)
Background. Human mesenchymal stromal/stem cells (hMSCs) hold great therapeutic potential due to their immunomodulatory and tissue regenerative properties. Enhancement of biological features of hMSCs by transfection has become a focus of investigatio
Externí odkaz:
https://doaj.org/article/54d5d27f90ca46f8a673c353b3dc1890