Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Jessie Qian"'
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 32, Iss 4, Pp 101352- (2024)
Evaluation of host integration profiles by adeno-associated virus (AAV) is an important component of de-risking novel AAV gene therapies. Targeted enrichment sequencing (TES) is a cost-effective and comprehensive method for assessing integration. Mos
Externí odkaz:
https://doaj.org/article/654cd3cfc1ad47d7988230718f57b959
Autor:
Elias M. Oziolor, Steven W. Kumpf, Jessie Qian, Mark Gosink, Mark Sheehan, David M. Rubitski, Leah Newman, Laurence O. Whiteley, Thomas A. Lanz
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 29, Iss , Pp 395-405 (2023)
Many current gene therapy targets use recombinant adeno-associated virus (AAV). The majority of delivered AAV therapeutics persist as episomes, separate from host DNA, yet some viral DNA can integrate into host DNA in different proportions and at gen
Externí odkaz:
https://doaj.org/article/408d92ef4a474a9ab96737ca95b99093
Autor:
Kenneth G. Geles, Yijie Gao, Andreas Giannakou, Latha Sridharan, Ting-Ting Yamin, Jing Zhang, Riyez Karim, Joel Bard, Nicole Piche-Nicholas, Manoj Charati, Andreas Maderna, Judy Lucas, Jonathon Golas, Magali Guffroy, Steven Pirie-Shepherd, Marc Roy, Jessie Qian, Tania Franks, Wenyan Zhong, Christopher J. O’Donnell, Lioudmila Tchistiakova, Hans-Peter Gerber, Puja Sapra
Publikováno v:
Cell Reports Medicine, Vol 2, Iss 5, Pp 100279- (2021)
Summary: Aberrant NOTCH3 signaling and overexpression is oncogenic, associated with cancer stem cells and drug resistance, yet therapeutic targeting remains elusive. Here, we develop NOTCH3-targeted antibody drug conjugates (NOTCH3-ADCs) by bioconjug
Externí odkaz:
https://doaj.org/article/76d0c5083adc4e25955529b3fcfbbf6d
Autor:
Paul Yenerall, Tae Sung, Kiran Palyada, Jessie Qian, Seda Arat, Steven W Kumpf, Shih-Wen Wang, Kathleen Biddle, Carlos Esparza, Stephanie Chang, Wesley Scott, Walter Collette, Taylor-Symon Winrow, Tim Affolter, Norimitsu Shirai, Stephane Thibault, Julia Wang, Ling Liu, Mary Bauchmann, Jessica Frey, Stefanus Steyn, Aida Sacaan, Allison Vitsky, Youngwook Ahn, Tom Paul, Lawrence Lum, Jon Oyer, Amy Yang, Wenyue Hu
Publikováno v:
Toxicological Sciences.
The degradation tag (dTAG) system for target protein degradation can remove proteins from biological systems without the drawbacks of some genetic methods, such as slow kinetics, lack of reversibility, low specificity, and the inability to titrate do
Autor:
Seda Arat, Renee Huynh, Steven Kumpf, Jessie Qian, Ahmed Shoieb, Richard Virgen‐Slane, Frank Voigt, Zhiyong Xie, John L. Jakubczak
Publikováno v:
The FASEB Journal. 37
Autor:
Shambhunath Choudhary, Isis Kanevsky, Soner Yildiz, Rani S. Sellers, Kena A. Swanson, Tania Franks, Raveen Rathnasinghe, Raquel Munoz-Moreno, Sonia Jangra, Olga Gonzalez, Philip Meade, Timothy Coskran, Jessie Qian, Thomas A. Lanz, Jillian G. Johnson, Cassandra A Tierney, Justin D. Smith, Kristin Tompkins, Arthur Illenberger, Paula Corts, Tara Ciolino, Philip R. Dormitzer, Edward J. Dick, Vinay Shivanna, Shannan Hall-Ursone, Journey Cole, Deepak Kaushal, Jane A. Fontenot, Carles Martinez-Romero, Meagan McMahon, Florian Krammer, Michael Schotsaert, Adolfo García-Sastre
Publikováno v:
Toxicologic Pathology
Coronavirus disease 2019 (COVID-19) in humans has a wide range of presentations, ranging from asymptomatic or mild symptoms to severe illness. Suitable animal models mimicking varying degrees of clinical disease manifestations could expedite developm
Autor:
Xavier Palazzi, Ingrid D. Pardo, Madhu P. Sirivelu, Leah Newman, Steven W. Kumpf, Jessie Qian, Tania Franks, Sarah Lopes, June Liu, Laura Monarski, Sandra Casinghino, Casey Ritenour, Hayley Ritenour, Christopher Dubois, Jennifer Olson, John Graves, Kristin E. Alexander, Timothy Coskran, Thomas A. Lanz, Joseph Brady, Douglas McCarty, Somanathan Suryanarayan, Laurence O. Whiteley
Publikováno v:
Human Gene Therapy. 33:175-187
Autor:
Wei Li, Kimberly K Crouse, Jennifer Alley, Richard K Frisbie, Susan C Fish, Tatyana A Andreyeva, Lori A Reed, Mitchell Thorn, Giovanni DiMaggio, Carol B Donovan, Donald Bennett, Jeonifer Garren, Elias Oziolor, Jessie Qian, Leah Newman, Amanda P Vargas, Steven W Kumpf, Stefanus Johannes Steyn, Mark E Schnute, Atli Thorarensen, Martin Hegen, Erin Stevens, Mark Collinge, Thomas A Lanz, Fabien Vincent, Michael S Vincent, Gabriel Berstein
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. :JPET-AR
Autor:
Xavier, Palazzi, Ingrid D, Pardo, Madhu P, Sirivelu, Leah, Newman, Steven W, Kumpf, Jessie, Qian, Tania, Franks, Sarah, Lopes, June, Liu, Laura, Monarski, Sandra, Casinghino, Casey, Ritenour, Hayley, Ritenour, Christopher, Dubois, Jennifer, Olson, John, Graves, Kristin E, Alexander, Timothy, Coskran, Thomas A, Lanz, Joseph, Brady, Douglas, McCarty, Somanathan, Suryanarayan, Laurence O, Whiteley
Publikováno v:
Human gene therapy. 33(3-4)
Recombinant adeno-associated viruses (AAVs) have emerged as promising vectors for human gene therapy, but some variants have induced severe toxicity in Rhesus monkeys and piglets following high-dose intravenous (IV) administration. To characterize bi
Autor:
Magali Guffroy, Steven Pirie-Shepherd, Puja Sapra, Judy Lucas, Jonathon Golas, Kenneth G. Geles, Joel Bard, Nicole Piche-Nicholas, Riyez Karim, Hans-Peter Gerber, Latha Sridharan, Lioudmila Tchistiakova, Andreas Giannakou, Jing Zhang, Manoj Charati, Tania Franks, Wenyan Zhong, Ting-Ting Yamin, Yijie Gao, Jessie Qian, Marc D. Roy, Andreas Maderna, Christopher J. O’Donnell
Publikováno v:
Cell Reports Medicine, Vol 2, Iss 5, Pp 100279-(2021)
Cell Reports Medicine
Cell Reports Medicine
Summary Aberrant NOTCH3 signaling and overexpression is oncogenic, associated with cancer stem cells and drug resistance, yet therapeutic targeting remains elusive. Here, we develop NOTCH3-targeted antibody drug conjugates (NOTCH3-ADCs) by bioconjuga