Structural basis for VPS34 kinase activation by Rab1 and Rab5 on membranes

Autor: Shirley Tremel, Yohei Ohashi, Dustin R. Morado, Jessie Bertram, Olga Perisic, Laura T. L. Brandt, Marie-Kristin von Wrisberg, Zhuo A. Chen, Sarah L. Maslen, Oleksiy Kovtun, Mark Skehel, Juri Rappsilber, Kathrin Lang, Sean Munro, John A. G. Briggs, Roger L. Williams

Publikováno v: Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)

The phosphatidylinositol-3-phosphate (PI3P) is generated by the lipid kinase VPS34, in the context of VPS34 complex I on autophagosomes or complex II on endosomes. Biochemical and structural analyses provide insights into the mechanism of both VPS34

Externí odkaz: https://doaj.org/article/d0b77c3d6f3f4cfcbbaf6326c8d008f3

Structural basis for VPS34 kinase activation by Rab1 and Rab5 on membranes

Autor: Marie-Kristin von Wrisberg, Juri Rappsilber, Olga Perisic, Roger L. Williams, Sarah L. Maslen, Dustin R. Morado, John A. G. Briggs, Kathrin Lang, Jessie Bertram, Shirley Tremel, Sean Munro, Mark Skehel, Oleksiy Kovtun, Yohei Ohashi, Zhuo A. Chen, Laura T L Brandt

Publikováno v: Nature Communications, 12
Tremel, S, Ohashi, Y, Morado, D R, Bertram, J, Perisic, O, Brandt, L T L, von Wrisberg, M K, Chen, Z A, Maslen, S L, Kovtun, O, Skehel, M, Rappsilber, J, Lang, K, Munro, S, Briggs, J A G & Williams, R L 2021, ' Structural basis for VPS34 kinase activation by Rab1 and Rab5 on membranes ', Nature Communications, vol. 12, 1564 . https://doi.org/10.1038/s41467-021-21695-2
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Nature Communications

The lipid phosphatidylinositol-3-phosphate (PI3P) is a regulator of two fundamental but distinct cellular processes, endocytosis and autophagy, so its generation needs to be under precise temporal and spatial control. PI3P is generated by two complex

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f817ee0df381ae701383613316007446
https://hdl.handle.net/20.500.11850/529518

In vivo identification of GTPase interactors by mitochondrial relocalization and proximity biotinylation

Autor: Jessie Bertram, Alison K. Gillingham, Farida Begum, Sean Munro

Publikováno v: eLife, Vol 8 (2019)
eLife

The GTPases of the Ras superfamily regulate cell growth, membrane traffic and the cytoskeleton, and a wide range of diseases are caused by mutations in particular members. They function as switchable landmarks with the active GTP-bound form recruitin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11c98aff044affc2e01cc471880b1470
https://elifesciences.org/articles/45916