Yeast PI31 inhibits the proteasome by a direct multisite mechanism

Autor: Shaun Rawson, Richard M. Walsh, Benjamin Velez, Helena M. Schnell, Fenglong Jiao, Marie Blickling, Jessie Ang, Meera K. Bhanu, Lan Huang, John Hanna

Publikováno v: Nature structural & molecular biology, vol 29, iss 8
Nat Struct Mol Biol

Proteasome inhibitors are widely used as therapeutics and research tools, and typically target one of the three active sites, each present twice in the proteasome complex. An endogeneous proteasome inhibitor, PI31, was identified 30 years ago, but it

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::241ea339fbfff75f9b6d6aea39b60c5d
https://escholarship.org/uc/item/5t7677k4

Regulation of the unfolded protein response in yeast by oxidative stress

Autor: John Hanna, Angel Guerra-Moreno, Hendrik Welsch, Marco Jochem, Jessie Ang

Publikováno v: FEBS Lett

In the unfolded protein response (UPR), Ire1 activates Hac1 to coordinate the transcription of hundreds of genes to mitigate ER stress. Recent work in Caenorhabditis elegans suggests that oxidative stress inhibits this canonical Ire1 signalling pathw

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::790044a23f1fae381645be1e8221269e
https://doi.org/10.1002/1873-3468.13389

Dysregulation of very-long-chain fatty acid metabolism causes membrane saturation and induction of the unfolded protein response

Autor: Jeffrey N. Agar, Walid M. Abdelmoula, Sankha S. Basu, Nathalie Y. R. Agar, Begoña Gimenez-Cassina Lopez, Yagmur Micoogullari, Nina Weisshaar, John Hanna, Jessie Ang, Nicholas D. Schmitt

Publikováno v: Molecular Biology of the Cell

The unfolded protein response (UPR) senses defects in the endoplasmic reticulum (ER) and orchestrates a complex program of adaptive cellular remodeling. Increasing evidence suggests an important relationship between lipid homeostasis and the UPR. Def

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7163f0bb1e14d24c22356e85c9b008b7
https://pubmed.ncbi.nlm.nih.gov/31746669

Targeted Degradation of Glucose Transporters Protects against Arsenic Toxicity

Autor: Jessie Ang, Marta Isasa, John Hanna, Steven P. Gygi, Meera K. Bhanu, Marco Jochem, Helena M. Schnell, Lukas Ende, Yagmur Micoogullari, Angel Guerra-Moreno

Publikováno v: Molecular and cellular biology. 39(10)

The abundance of cell surface glucose transporters must be precisely regulated to ensure optimal growth under constantly changing environmental conditions. We recently conducted a proteomic analysis of the cellular response to trivalent arsenic, a ub

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fbc1d21022e925d8156e954c8a11ea91
https://pubmed.ncbi.nlm.nih.gov/30886123

A novel pathway of targeted autophagy is induced by DNA damage in budding yeast

Autor: Vinay Eapen, David Waterman, Amélie Bernard, Nathan Schiffman, Enrich Sayas, Roarke Kamber, Brenda Lemos, Gonen Memisoglu, Jessie Ang, Allison Mazella, Chuartzman, Silvia G., Loewith, Robbie J., Maya Schuldiner, Vladimir Denic, Klionsky, Daniel J., Haber, James E.

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the United States of America, National Academy of Sciences, 2017
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International audience

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::5c9c356f322b41045a6386107bf0d1a6
https://hal.archives-ouvertes.fr/hal-03156537