Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Jessica Z. Chan"'
Publikováno v:
Journal of the American Chemical Society. 143:2441-2455
We disclose a catalytic method for β-C(sp3)-H functionalization of N-alkylamines for the synthesis of enantiomerically enriched β-substituted amines, entities prevalent in pharmaceutical compounds and used to generate different families of chiral c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9050a8006b7a298ac3c5c90fc09236f8
https://doi.org/10.1021/jacs.0c13200
https://doi.org/10.1021/jacs.0c13200
Publikováno v:
Organic Letters. 21:984-988
An efficient method for the coupling of N-alkylamines with silicon enolates to generate β-amino carbonyl compounds is disclosed. These reactions proceed by activation of α-amino C–H bonds by B(C(6)F(5))(3), which likely generates a “frustrated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3354ba5e23c08a8731c63c370fcdc3c0
https://doi.org/10.1021/acs.orglett.8b03959
https://doi.org/10.1021/acs.orglett.8b03959
Autor:
Yejin, Chang, Min, Cao, Jessica Z, Chan, Cunyuan, Zhao, Yuankai, Wang, Rose, Yang, Masayuki, Wasa
Publikováno v:
J Am Chem Soc
We disclose a catalytic method for β-C(sp(3))–H functionalization of N-alkylamines for synthesis of enantiomerically enriched β-substituted amines, entities prevalent in pharmaceutical compounds and used to generate different families of chiral c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::b4e5ad29aa203245c733ba4c5e08ed90
https://pubmed.ncbi.nlm.nih.gov/33512998
https://pubmed.ncbi.nlm.nih.gov/33512998
Publikováno v:
J Am Chem Soc
An efficient catalytic method to convert an α-C-H bond of N-alkylamines into an α-C-alkynyl bond was developed. In the past, such transformations were carried out under oxidative conditions, and the enantioselective variants were confined to tetrah
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b53d763a502435ae629e30ca549dbe51
https://europepmc.org/articles/PMC8048775/
https://europepmc.org/articles/PMC8048775/
Publikováno v:
ACS Medicinal Chemistry Letters. 8:455-460
Some norbenzomorphans exhibit high affinity for sigma 1 and sigma 2 receptors, and varying the position of substituents on the aromatic ring of this scaffold has a significant effect on subtype selectivity. In particular, compounds bearing several di
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27c8bbe1219708de726498ecc7c5222b
https://doi.org/10.1021/acsmedchemlett.7b00066
https://doi.org/10.1021/acsmedchemlett.7b00066
Autor:
Jessica Z. Chan, Jonathan T. Pierce, Pooneh Memar Ardestani, Luisa L. Scott, Stephen F. Martin, Bitna Yi, Sangeetha Iyer, Ashley Crisp, Gabriella Zuniga, Andrew K. Evans, James J. Sahn, Mehrdad Shamloo
Publikováno v:
Journal of Neurochemistry. 140:561-575
Accumulating evidence suggests that modulating the sigma 2 receptor (Sig2R) can provide beneficial effects for neurodegenerative diseases. Herein, we report the identification of a novel class of Sig2R binding ligands and their cellular and in vivo a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b968f3d4ba46d0ef43eb98e150b2bda
https://doi.org/10.1111/jnc.13917
https://doi.org/10.1111/jnc.13917
Autor:
Min Cao, Bochao Zhang, Masayuki Wasa, Yejin Chang, Yuyang Zhang, Ahmet Yesilcimen, Jessica Z. Chan
Publikováno v:
Journal of the American Chemical Society. 141(37)
An efficient deuteration process of β-amino C─H bonds in various N-alkylamine-based pharmaceutical compounds has been developed. Catalytic reactions begin with the action of Lewis acidic B(C(6)F(5))(3) and Brønsted basic N-alkylamine, converting
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b98e9f8fdf4b31bd80f899eb13b76560
https://pubmed.ncbi.nlm.nih.gov/31480842
https://pubmed.ncbi.nlm.nih.gov/31480842
Publikováno v:
Angewandte Chemie. 128:14081-14085
Direct Mannich-type reactions that afford both α- and β-amino esters by the reaction of a broad range of carbonyl compounds and aldimines are disclosed. The transformation is promoted by a sterically frustrated Lewis acid/Brønsted base pair, which
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19c7148cb33bf47f7144583ca38533a9
https://doi.org/10.1002/ange.201608583
https://doi.org/10.1002/ange.201608583
Autor:
Yejin Chang, Jessica Z. Chan, Ming Shang, Masayuki Wasa, Qifan Wang, Min Cao, Sebastian Torker, Brennan Cook
Catalytic transformations of α-amino C–H bonds to afford valuable enantiomerically enriched α-substituted amines, entities that are prevalent in pharmaceuticals and bioactive natural products, have been developed. Typically, such processes are ca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f66327bdb125738cfca32b098f1c60b6
https://europepmc.org/articles/PMC6542567/
https://europepmc.org/articles/PMC6542567/
Autor:
Jennifer Youn, Seung Moh Koo, Jessica Z. Chan, Brian T. Hastings, Wenzhi Yao, Xiaoxu Wang, Ming Shang, Masayuki Wasa
Publikováno v:
Journal of the American Chemical Society. 139(1)
A method for enantioselective direct α-amination reaction catalyzed by a sterically “frustrated” Lewis acid/Bronsted base complex is disclosed. Cooperative functioning of the Lewis acid and Bronsted base components gives rise to in situ enolate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8822964afc7596ed265c859e37125e25
https://pubmed.ncbi.nlm.nih.gov/27983825
https://pubmed.ncbi.nlm.nih.gov/27983825