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Autor:
Tina Hennerici, Johan Bäcklund, Sebastian Willenborg, Rikard Holmdahl, Grete Sønderstrup, Claudio Feliciani, Jessica Wohde, Michael Hertl, Kevin C. Visconti, Rüdiger Eming
Publikováno v:
The Journal of Immunology. 193:4391-4399
Pemphigus vulgaris (PV) is considered as a model for an autoantibody-mediated organ-specific autoimmune disorder. IgG autoantibodies directed against the desmosomal cadherin desmoglein 3 (Dsg3), the major autoantigen in PV, cause loss of epidermal ke