Výsledky vyhledávání - "Jessica Weant"

Acceleration of Regeneration of the Corneal Endothelial Layer After Descemet Stripping Induced by the Engineered FGF TTHX1114 in Human Corneas in Organ Culture

Autor: Sarah Pizzuto, Grace Duffey, Jessica Weant, David Eveleth

Publikováno v: Cornea. 42:232-242

Descemet stripping only (DSO, descemetorhexis without endothelial keratoplasty) is increasing in clinical use but can impose long recovery times. The objective of this research was to determine whether TTHX1114, an engineered analog of FGF1, could ac

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c7e662d040d214fb5dcfeb1d9cebb6c
https://doi.org/10.1097/ico.0000000000003098

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A Human Corneal Organ Culture Model of Descemet's Stripping Only with Accelerated Healing Stimulated by Engineered Fibroblast Growth Factor 1

Autor: David Eveleth, Jessica Weant, Grace Duffey, Sarah Pizzuto

Publikováno v: Journal of visualized experiments : JoVE. (185)

Fuchs Endothelial Corneal Dystrophy (FECD) results from dysfunctional corneal endothelial cells (CECs) and is currently treated by transplantation of the whole cornea or Descemet's membrane. Recent developments in ocular surgery have established Desc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9e6b2af2a42d663bf199f46e44d4f50
https://pubmed.ncbi.nlm.nih.gov/35938798

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Regenerative responses of rabbit corneal endothelial cells to stimulation by fibroblast growth factor 1 (FGF1) derivatives, TTHX1001 and TTHX1114

Autor: Jessica Weant, David D. Eveleth, Amuthakannan Subramaniam, Jennifer Jenkins-Eveleth, Michael Blaber, Ling Li, David M. Ornitz, Asaf Alimardanov, Trevor Broadt, Hui Dong, Vinay Vyas, Xiaoyi Yang, Ralph A. Bradshaw

Publikováno v: Growth Factors. 39:14-27

Utilising rabbit corneal endothelial cells (CEC) in three different paradigms, two human FGF1 derivatives (TTHX1001 and TTHX1114), engineered to exhibit greater stability, were tested as proliferative agents. Primary CECs and mouse NIH 3T3 cells trea

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58a02a16950f215d35b6e51589736f2c
https://doi.org/10.1080/08977194.2021.2012468

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Proliferation of Human Corneal Endothelia in Organ Culture Stimulated by Wounding and the Engineered Human Fibroblast Growth Factor 1 Derivative TTHX1114

Autor: Ralph A. Bradshaw, Jennifer Jenkins-Eveleth, Jessica Weant, Sarah Pizzuto, David Eveleth

Publikováno v: Journal of Ocular Pharmacology and Therapeutics

Purpose: Corneal endothelial dystrophies are characterized by endothelial cell loss and dysfunction. Recent evidence suggests that corneal endothelial cells (CECs) can regenerate although they do not do so under normal conditions. This work sought to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cca47f0e3d24ad0772bdae26cff98381
https://doi.org/10.1089/jop.2019.0119

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Critical reagent stability for immunogenicity assays

Autor: Arron S. L. Xu, Jessica Weant

Publikováno v: Immunogenicity Assay Development, Validation and Implementation. :92-104

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::fd0cb402c3d3954ccc195de992240f91
https://doi.org/10.4155/ebo.13.422

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