Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Jessica W Luzwick"'
Autor:
Sunetra Roy, Karl-Heinz Tomaszowski, Jessica W Luzwick, Soyoung Park, Jun Li, Maureen Murphy, Katharina Schlacher
Publikováno v:
eLife, Vol 7 (2018)
Classically, p53 tumor suppressor acts in transcription, apoptosis, and cell cycle arrest. Yet, replication-mediated genomic instability is integral to oncogenesis, and p53 mutations promote tumor progression and drug-resistance. By delineating human
Externí odkaz:
https://doaj.org/article/d59ddfa5c38f4f2cae38704cb46a36dd
Autor:
Kareem N Mohni, Petria S Thompson, Jessica W Luzwick, Gloria G Glick, Christopher S Pendleton, Brian D Lehmann, Jennifer A Pietenpol, David Cortez
Publikováno v:
PLoS ONE, Vol 10, Iss 5, p e0125482 (2015)
The DNA damage response kinase ATR may be a useful cancer therapeutic target. ATR inhibition synergizes with loss of ERCC1, ATM, XRCC1 and DNA damaging chemotherapy agents. Clinical trials have begun using ATR inhibitors in combination with cisplatin
Externí odkaz:
https://doaj.org/article/f9c69894fe6f41d8ba3ba6c828bd46d4
Publikováno v:
PLoS ONE, Vol 9, Iss 6, p e99397 (2014)
Subcellular localization, protein interactions, and post-translational modifications regulate the DNA damage response kinases ATR, ATM, and DNA-PK. During an analysis of putative ATR phosphorylation sites, we found that a single mutation at S1333 cre
Externí odkaz:
https://doaj.org/article/02b19fd7ea9e4355a8c0f3b1cd9b3b13
Autor:
Jessica W. Luzwick, Eszter Dombi, Rebecca A. Boisvert, Sunetra Roy, Soyoung Park, Selvi Kunnimalaiyaan, Steffi Goffart, Detlev Schindler, Katharina Schlacher
Publikováno v:
Science Advances
Description
MRE11 activates mitochondrial DNA–dependent cGAS immune signaling in cells with BRCA/FANC gene defects.
Mitochondrial DNA (mtDNA) instability activates cGAS-dependent innate immune signaling by unknown mechanisms. Here, we fin
MRE11 activates mitochondrial DNA–dependent cGAS immune signaling in cells with BRCA/FANC gene defects.
Mitochondrial DNA (mtDNA) instability activates cGAS-dependent innate immune signaling by unknown mechanisms. Here, we fin
Autor:
Selvi Kunnimalaiyaan, Sunetra Roy, Jessica w. Luzwick, Rebecca A. Boisvert, Soyoung Park, Steffi Goffart, Katharina Schlacher, Detlev Schindler
Publikováno v:
SSRN Electronic Journal.
Mitochondrial DNA instability activates cGAS and the innate immune system by unknown mechanisms. Here, we find that Fanconi anemia suppressor genes are acting in the mitochondria to protect mitochondrial DNA replication forks from instability. Specif
Autor:
D. Reid Putney, Michael D. Feldkamp, Clinton Carroll, Gloria G. Glick, Thomas E. Bass, David Cortez, Walter J. Chazin, Gina Kavanaugh, Huzefa Dungrawala, Jessica W. Luzwick
Publikováno v:
Nature Cell Biology. 18:1185-1195
The ATR checkpoint kinase coordinates cellular responses to DNA replication stress. Budding yeast contain three activators of Mec1 (the ATR orthologue); however, only TOPBP1 is known to activate ATR in vertebrates. We identified ETAA1 as a replicatio
Autor:
Karl Heinz Tomaszowski, Jessica W. Luzwick, Maureen E. Murphy, Soyoung Park, Sunetra Roy, Katharina Schlacher, Jun Li
Publikováno v:
eLife
eLife, Vol 7 (2018)
eLife, Vol 7 (2018)
When a cell divides to make more cells, it duplicates its DNA to pass on an identical set of genes to the new cell. Copying DNA – also known as DNA replication – is a complex process that involves several steps. First, the double helix gradually
Autor:
Alex G. Waterson, Stephen W. Fesik, David Cortez, Jessica W. Luzwick, Edward T. Olejniczak, Michael D. Feldkamp, Elaine M. Souza-Fagundes, Andreas O. Frank, Bhavatarini Vangamudi, Olivia W. Rossanese, Walter J. Chazin
Publikováno v:
Journal of Medicinal Chemistry
Stapled helix peptides can serve as useful tools for inhibiting protein-protein interactions but can be difficult to optimize for affinity. Here we describe the discovery and optimization of a stapled helix peptide that binds to the N-terminal domain
Publikováno v:
Cell reports
Cell Reports, Vol 28, Iss 13, Pp 3497-3509.e4 (2019)
Cell Reports, Vol 28, Iss 13, Pp 3497-3509.e4 (2019)
SUMMARY Identifying proteins that function at replication forks is essential to understanding DNA replication, chromatin assembly, and replication-coupled DNA repair mechanisms. Combining quantitative mass spectrometry in multiple cell types with str