Zobrazeno 1 - 10
of 50
pro vyhledávání: '"Jessica W Chen"'
Autor:
Megan Levy, Jessica W Chen, Jaclyn A Kaiser, Hong-Su Park, Xueqiao Liu, Lijuan Yang, Celia Santos, Ursula J Buchholz, Cyril Le Nouën
Publikováno v:
PLoS Pathogens, Vol 20, Iss 5, p e1012198 (2024)
Respiratory syncytial virus (RSV) is the most important viral agent of severe pediatric respiratory illness worldwide, but there is no approved pediatric vaccine. Here, we describe the development of the live-attenuated RSV vaccine candidate Min AL a
Externí odkaz:
https://doaj.org/article/0125f493245a43bd86c11a2816ec7e68
Autor:
Jessica W. Chen, William Jacot, Javier Cortés, Ian E. Krop, Susan Dent, Nadia Harbeck, Michelino De Laurentiis, Véronique Diéras, Young‐Hyuck Im, Thomas J. Stout, Frauke Schimmoller, Heidi M. Savage, Katherine E. Hutchinson, Timothy R. Wilson
Publikováno v:
Molecular Oncology, Vol 17, Iss 10, Pp 2000-2016 (2023)
Taselisib is a potent β‐sparing phosphatidylinositol 3‐kinase (PI3K) inhibitor that, with endocrine therapy, improves outcomes in phosphatidylinositol‐4,5‐bisphosphate 3‐kinase catalytic subunit alpha (PIK3CA)‐mutated (PIK3CAmut) advance
Externí odkaz:
https://doaj.org/article/535a6a7921404a8298c1f95b55637007
Autor:
Katherine E. Hutchinson, Jessica W. Chen, Heidi M. Savage, Thomas J. Stout, Frauke Schimmoller, Javier Cortés, Susan Dent, Nadia Harbeck, William Jacot, Ian Krop, Sally E. Trabucco, Smruthy Sivakumar, Ethan S. Sokol, Timothy R. Wilson
Publikováno v:
Genome Medicine, Vol 15, Iss 1, Pp 1-14 (2023)
Abstract Background Mutations in the p110α catalytic subunit of phosphatidylinositol 3-kinase (PI3K), encoded by the PIK3CA gene, cause dysregulation of the PI3K pathway in 35–40% of patients with HR+/HER2– breast cancer. Preclinically, cancer c
Externí odkaz:
https://doaj.org/article/6a84c1824dfc43c99cd063f56d446e86
Autor:
Yannic C. Bartsch, Jessica W. Chen, Jaewon Kang, Madeleine D. Burns, Kerri J. St Denis, Maegan L. Sheehan, Jameson P. Davis, Andrea G. Edlow, Alejandro B. Balazs, Lael M. Yonker, Galit Alter
Publikováno v:
npj Vaccines, Vol 7, Iss 1, Pp 1-10 (2022)
Abstract Currently available mRNA vaccines are extremely safe and effective to prevent severe SARS-CoV-2 infections. However, the emergence of variants of concerns (VOCs) has highlighted the importance of high population-based vaccine rates to effect
Externí odkaz:
https://doaj.org/article/3c683d6a00f5452bbe48e6ed7480869d
Autor:
Jessica W Chen, Lijuan Yang, Celia Santos, Sergio A Hassan, Peter L Collins, Ursula J Buchholz, Cyril Le Nouën
Publikováno v:
PLoS Pathogens, Vol 17, Iss 12, p e1010191 (2021)
Recoding viral genomes by introducing numerous synonymous nucleotide substitutions that create suboptimal codon pairs provides new live-attenuated vaccine candidates. Because recoding typically involves a large number of nucleotide substitutions, the
Externí odkaz:
https://doaj.org/article/8c178583c7004955bec99733a25f6037
Autor:
Madeleine D. Burns, Brittany P. Boribong, Yannic C. Bartsch, Maggie Loiselle, Kerri J. St. Denis, Maegan L. Sheehan, Jessica W. Chen, Jameson P. Davis, Rosiane Lima, Andrea G. Edlow, Alessio Fasano, Alejandro B. Balazs, Galit Alter, Lael M. Yonker
Publikováno v:
Vaccines, Vol 10, Iss 4, p 492 (2022)
Emergent SARS-CoV-2 variants and waning humoral immunity in vaccinated individuals have resulted in increased infections and hospitalizations. Children are not spared from infection nor complications of COVID-19, and the recent recommendation for boo
Externí odkaz:
https://doaj.org/article/f0b7c981c57843128b5e838beb29e3c3
Autor:
Neil Vasan, Ethan S. Sokol, Timothy R. Wilson, Katherine E. Hutchinson, Jessica W. Chen, Maurizio Scaltriti, Lewis C. Cantley, Jeffrey Ross, Ruchita Rathod, Dexter X. Jin, Smruthy Sivakumar
Serine and threonine phosphoproteome of NIH-3T3 cells bearing PIK3CA E726K/H1047R vs H1047R.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e8737d9ce5daf72b64bc91593d302e9
https://doi.org/10.1158/1078-0432.22490002
https://doi.org/10.1158/1078-0432.22490002
Autor:
Neil Vasan, Ethan S. Sokol, Timothy R. Wilson, Katherine E. Hutchinson, Jessica W. Chen, Maurizio Scaltriti, Lewis C. Cantley, Jeffrey Ross, Ruchita Rathod, Dexter X. Jin, Smruthy Sivakumar
Purpose:To comprehensively characterize tissue-specific and molecular subclasses of multiple PIK3CA (multi-PIK3CA) mutations and assess their impact on potential therapeutic outcomes.Experimental Design:We profiled a pan-cancer cohort comprised of 35
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d3f3235ed5eaa112a1874926df2e217
https://doi.org/10.1158/1078-0432.c.6533080.v1
https://doi.org/10.1158/1078-0432.c.6533080.v1
Autor:
Neil Vasan, Ethan S. Sokol, Timothy R. Wilson, Katherine E. Hutchinson, Jessica W. Chen, Maurizio Scaltriti, Lewis C. Cantley, Jeffrey Ross, Ruchita Rathod, Dexter X. Jin, Smruthy Sivakumar
Table S1: Clinico-demographic characteristics of single- and multi-PIK3CA mutant tumors; Table S2: Prevalence of single and multi-PIK3CA mutated tumors across all tumor types; Table S3: Prevalence of single and multi-PIK3CA mutated tumors across pan-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7bdbfea24313bbb273656bf907ab38a5
https://doi.org/10.1158/1078-0432.22489996
https://doi.org/10.1158/1078-0432.22489996
Autor:
Jessica W. Chen, William Jacot, Javier Cortés, Ian E. Krop, Susan Dent, Nadia Harbeck, Michelino De Laurentiis, Véronique Diéras, Young‐Hyuck Im, Thomas J. Stout, Frauke Schimmoller, Heidi M. Savage, Katherine E. Hutchinson, Timothy R. Wilson
Publikováno v:
Molecular Oncology.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::eb5fc7e392ebbb21800edd297bf6e646
https://doi.org/10.1002/1878-0261.13416
https://doi.org/10.1002/1878-0261.13416