Zobrazeno 1 - 6 of 6 pro vyhledávání: '"Jessica Voisin"'
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Akademický článek
The Wnt receptor Ryk reduces neuronal and cell survival capacity by repressing FOXO activity during the early phases of mutant huntingtin pathogenicity.
Autor: Cendrine Tourette, Francesca Farina, Rafael P Vazquez-Manrique, Anne-Marie Orfila, Jessica Voisin, Sonia Hernandez, Nicolas Offner, J Alex Parker, Sophie Menet, Jinho Kim, Jungmok Lyu, Si Ho Choi, Kerry Cormier, Christina K Edgerly, Olivia L Bordiuk, Karen Smith, Anne Louise, Michael Halford, Steven Stacker, Jean-Philippe Vert, Robert J Ferrante, Wange Lu, Christian Neri
Publikováno v: PLoS Biology, Vol 12, Iss 6, p e1001895 (2014)
The Wnt receptor Ryk is an evolutionary-conserved protein important during neuronal differentiation through several mechanisms, including γ-secretase cleavage and nuclear translocation of its intracellular domain (Ryk-ICD). Although the Wnt pathway
Externí odkaz: https://doaj.org/article/30fe5f15c42b4abcbb453493275b5e19
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2
The Wnt Receptor Ryk Reduces Neuronal and Cell Survival Capacity by Repressing FOXO Activity During the Early Phases of Mutant Huntingtin Pathogenicity
Autor: Olivia L. Bordiuk, Nicolas Offner, Anne-Marie Orfila, Robert J. Ferrante, Rafael P. Vázquez-Manrique, Michael M. Halford, Jinho Kim, Christina K. Edgerly, Wange Lu, Cendrine Tourette, Karen M. Smith, Anne Louise, Sonia Hernandez, Kerry Cormier, Jean-Philippe Vert, Si Ho Choi, Jungmok Lyu, J. Alex Parker, Francesca Farina, Steven A. Stacker, Christian Neri, Sophie Menet, Jessica Voisin
Publikováno v: PLoS Biology
PLoS Biology, Public Library of Science, 2014, 12 (6), pp.e1001895. ⟨10.1371/journal.pbio.1001895⟩
PLoS Biology, 2014, 12 (6), pp.e1001895. ⟨10.1371/journal.pbio.1001895⟩
PLoS Biology, Public Library of Science, 2014, 12 (6), pp.e1001895. 〈10.1371/journal.pbio.1001895〉
PLOS BIOLOGY
r-IIS La Fe. Repositorio Institucional de Producción Científica del Instituto de Investigación Sanitaria La Fe
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PLoS Biology, Vol 12, Iss 6, p e1001895 (2014)
A study of Huntington's disease reveals that neurons might fail to cope with maintaining their function during the pre-symptomatic, pathogenic phases of HD, possibly due to the early repression of key longevity-promoting transcription factors by abno
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::427bed9b6b241ccd95a774a759d7f997
https://hal.archives-ouvertes.fr/hal-01076146/file/journal.pbio.1001895-1.pdf
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3
B39 Modelling and biological evidence for alteration of extracellular vesicles in huntington’s disease
Autor: Jessica Voisin, Satish Sasidharan Nair, Clotilde Théry, Christian Neri, Frédéric Parmentier, François-Xavier Lejeune, Francesca Farina
Publikováno v: Journal of Neurology, Neurosurgery & Psychiatry. 87:A23.1-A23
Intercellular communication mediated by extracellular vesicles (EV) is emerging as a mechanism that is important to neuronal homeostasis and integrity. However, there is little information available on the importance of EV signalling in response to p
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d4c81d8c1cbe332211d7ce826ab1fd66
https://doi.org/10.1136/jnnp-2016-314597.70
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4
B19 RNAseq and chipseq analysis of FOXO3 targets in an huntington’s disease human neural stem cell model
Autor: Francesca Farina, Christian Neri, François-Xavier Lejeune, Jessica Voisin, Lisa M. Ellerby
Publikováno v: Journal of Neurology, Neurosurgery & Psychiatry. 87:A15.3-A16
The stress resilience and cell survival factor FOXO3 has neuroprotective effects in several models of neurodegenerative diseases, including Huntington’s disease (HD). However, how this transcription factor may precisely promote neuroprotection agai
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::23a14365cc8c80cd56a1c1e4a634a724
https://doi.org/10.1136/jnnp-2016-314597.50
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B19 The Wnt Receptor Ryk Reduces Neuronal Resistance Capacity By Repressing Foxo Activity During The Early Phases Of Huntingtin Pathogenicity
Autor: SH Choi, S Menet, Rafael P. Vázquez-Manrique, Jinho Kim, Christina K. Edgerly, Cendrine Tourette, Wange Lu, Jessica Voisin, Anne-Marie Orfila, S Hernandez, J Lyu, Robert J. Ferrante, J. A. Parker, Jean-Philippe Vert, S Stacker, Francesca Farina, Olivia L. Bordiuk, Karen M. Smith, Christian Neri, K Cormier, Nicolas Offner, M Halford, Anne Louise
Publikováno v: Journal of Neurology, Neurosurgery & Psychiatry. 85:A15-A15
Background The ability of neurons to cope with the chronic stress induced by mutant protein expression in Huntington’s disease (HD) may determine the course of their decline and eventual demise. Although the pathophysiological importance of stress
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e7c562766a764a0cd2956dd50f2bdb39
https://doi.org/10.1136/jnnp-2014-309032.47
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6
B04 AMPK activation alleviates phenotypes associated to the early phases of mutant polyQ cytoxicity
Autor: A-M Orfila, Jessica Voisin, Karine Cambon, Christian Neri, Rafael P. Vázquez-Manrique, Andreas Weiss, Francesca Farina, Nicole Déglon
Publikováno v: Journal of Neurology, Neurosurgery & Psychiatry. 83:A6.3-A7
Background Huntington9s disease (HD) is a neurodegenerative disorder induced by cell toxicity caused by polyglutamine (polyQ) expansion in the N-terminal region of huntingtin (Htt). We use C elegans expressing 128Q in neurons to screen for genes that
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::47c25ed0b7c7a0cae112a017c575ffd6
https://doi.org/10.1136/jnnp-2012-303524.20
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