Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Jessica Tome‑Garcia"'
Autor:
Balagopal Pai, Jessica Tome-Garcia, Wan Sze Cheng, German Nudelman, Kristin G. Beaumont, Saadi Ghatan, Fedor Panov, Elodia Caballero, Kwadwo Sarpong, Lara Marcuse, Jiyeoun Yoo, Yan Jiang, Anne Schaefer, Schahram Akbarian, Robert Sebra, Dalila Pinto, Elena Zaslavsky, Nadejda M. Tsankova
Publikováno v:
Acta Neuropathologica Communications, Vol 10, Iss 1, Pp 1-19 (2022)
Abstract The pathophysiology of epilepsy underlies a complex network dysfunction between neurons and glia, the molecular cell type-specific contributions of which remain poorly defined in the human disease. In this study, we validated a method that s
Externí odkaz:
https://doaj.org/article/b9a46178f9344e43baf3916ddbf90fec
Autor:
Balagopal Pai, Jessica Tome‑Garcia, Wan Sze Cheng, German Nudelman, Kristin G. Beaumont, Saadi Ghatan, Fedor Panov, Elodia Caballero, Kwadwo Sarpong, Lara Marcuse, Jiyeoun Yoo, Yan Jiang, Anne Schaefer, Schahram Akbarian, Robert Sebra, Dalila Pinto, Elena Zaslavsky, Nadejda M. Tsankova
Publikováno v:
Acta Neuropathologica Communications, Vol 10, Iss 1, Pp 1-2 (2022)
Externí odkaz:
https://doaj.org/article/7d07701130ab484cb8642f0fb82b0e9b
Autor:
Melissa Umphlett, Stephanie Shea, Jessica Tome-Garcia, Yizhou Zhang, Adilia Hormigo, Mary Fowkes, Nadejda M. Tsankova, Raymund L. Yong
Publikováno v:
BMC Cancer, Vol 20, Iss 1, Pp 1-8 (2020)
Abstract Background Glioblastoma (GBM) is a highly malignant brain neoplasm with poor survival. Despite its aggressive nature, metastatic spread of GBM is identified only rarely. While the molecular alterations associated with GBM and its subtypes ar
Externí odkaz:
https://doaj.org/article/55a688632fdb4857adb89bd21cccb2a8
Autor:
Rut Tejero, Yong Huang, Igor Katsyv, Michael Kluge, Jung-Yi Lin, Jessica Tome-Garcia, Nicolas Daviaud, Yuanshuo Wang, Bin Zhang, Nadejda M. Tsankova, Caroline C. Friedel, Hongyan Zou, Roland H. Friedel
Publikováno v:
EBioMedicine, Vol 42, Iss , Pp 252-269 (2019)
Background: Glioblastoma (GBM), a highly malignant brain tumor, invariably recurs after therapy. Quiescent GBM cells represent a potential source of tumor recurrence, but little is known about their molecular underpinnings. Methods: Patient-derived G
Externí odkaz:
https://doaj.org/article/738fbc64fbbe40599149dda3de204610
Analysis of chromatin accessibility uncovers TEAD1 as a regulator of migration in human glioblastoma
Autor:
Jessica Tome-Garcia, Parsa Erfani, German Nudelman, Alexander M. Tsankov, Igor Katsyv, Rut Tejero, Bin Zhang, Martin Walsh, Roland H. Friedel, Elena Zaslavsky, Nadejda M. Tsankova
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
The intrinsic drivers of glioblastoma (GBM) migration are still poorly understood. Here the authors purify GBM stem cells (GSCs) from patients and profile chromatin accessibility in these cells, identifying TEAD1 as a regulator of migration in human
Externí odkaz:
https://doaj.org/article/2866f4fd16df494d96b315c2101ad08d
Autor:
Jessica Tome-Garcia, Rut Tejero, German Nudelman, Raymund L. Yong, Robert Sebra, Huaien Wang, Mary Fowkes, Margret Magid, Martin Walsh, Violeta Silva-Vargas, Elena Zaslavsky, Roland H. Friedel, Fiona Doetsch, Nadejda M. Tsankova
Publikováno v:
Stem Cell Reports, Vol 8, Iss 5, Pp 1421-1429 (2017)
Characterization of non-neoplastic and malignant human stem cell populations in their native state can provide new insights into gliomagenesis. Here we developed a purification strategy to directly isolate EGFR+/− populations from human germinal ma
Externí odkaz:
https://doaj.org/article/dcf92890d2b3457097348183485635a2
Publikováno v:
Bio-Protocol, Vol 7, Iss 24 (2017)
Direct isolation of human neural and glioma stem cells from fresh tissues permits their biological study without prior culture and may capture novel aspects of their molecular phenotype in their native state. Recently, we demonstrated the ability to
Externí odkaz:
https://doaj.org/article/c59cbe031b0e45558f9342260c17ea01
Publikováno v:
PLoS ONE, Vol 9, Iss 6, p e99525 (2014)
Despite all the blood-based biomarkers used to monitor prostate cancer patients, prostate cancer remains as the second common cause of cancer mortality in men in the United States. This is largely due to a lack of understanding of the molecular pathw
Externí odkaz:
https://doaj.org/article/be6aec0d42a542f6a8a764e722eac1ca
Publikováno v:
J Vis Exp
The complexity of human astrocytes remains poorly defined in primary human tissue, requiring better tools for their isolation and molecular characterization. Fluorescence-activated nuclei sorting (FANS) can be used to successfully isolate and study h
Autor:
Hanna Pincas, Nadejda M. Tsankova, Yongchao Ge, Stuart C. Sealfon, Peter Smibert, Harold Swerdlow, Jessica Tome-Garcia, Venugopalan D. Nair, Gregory R. Smith, Boris M. Hartmann, Michel Zamojski, Miguel Fribourg, Daniel J. Bernard, Chirine Toufaily, Marlon Stoeckius, Frederique Ruf-Zamojski, William Stephenson, Judith L Turgeon
Publikováno v:
Ruf-Zamojski, Frederique; Ge, Yongchao; Nair, Venugopalan; Zamojski, Michel; Pincas, Hanna; Toufaily, Chirine; et al.(2018). Single-cell stabilization method identifies gonadotrope transcriptional dynamics and pituitary cell type heterogeneity.. Nucleic acids research, 46(21), 11370-11380. doi: 10.1093/nar/gky991. UC Davis: Retrieved from: http://www.escholarship.org/uc/item/273146m1
Nucleic Acids Research
Nucleic Acids Research
Immediate-early response genes (IEGs) are rapidly and transiently induced following an extracellular signal. Elucidating the IEG response patterns in single cells (SCs) requires assaying large numbers of timed samples at high accuracy while minimizin