Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Jessica T.Y. Yue"'
Autor:
Patricia O. Benedet, Nooshin S. Safikhan, Maria J. Pereira, Bryan M. Lum, José Diego Botezelli, Cheng-Hsiang Kuo, Hua-Lin Wu, Barbara P. Craddock, W. Todd Miller, Jan W. Eriksson, Jessica T.Y. Yue, Edward M. Conway
Publikováno v:
EBioMedicine, Vol 99, Iss , Pp 104906- (2024)
Summary: Background: In spite of new treatments, the incidence of type 2 diabetes (T2D) and its morbidities continue to rise. The key feature of T2D is resistance of adipose tissue and other organs to insulin. Approaches to overcome insulin resistanc
Externí odkaz:
https://doaj.org/article/662c11ff3e454063835ffc5b1b5616ba
Autor:
Rosa J.W. Li, Battsetseg Batchuluun, Song-Yang Zhang, Mona A. Abraham, Beini Wang, Yu-Mi Lim, Jessica T.Y. Yue, Tony K.T. Lam
Publikováno v:
iScience, Vol 24, Iss 4, Pp 102366- (2021)
Summary: Hypothalamic regulation of lipid and glucose homeostasis is emerging, but whether the dorsal vagal complex (DVC) senses nutrients and regulates hepatic nutrient metabolism remains unclear. Here, we found in rats DVC oleic acid infusion suppr
Externí odkaz:
https://doaj.org/article/372210e912e1406abc4ba8cdaacfc1b7
Autor:
Rosa J.W. Li, Jennifer F.M. Chiu, Kyla Bruce, Song-Yang Zhang, Daniel R. Barros, Jessica T.Y. Yue, Tony K.T. Lam
Publikováno v:
Journal of Biological Chemistry. 299:104633
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4e50e2b77b5194bf9f31863ec61ec28f
https://doi.org/10.1016/j.jbc.2023.104633
https://doi.org/10.1016/j.jbc.2023.104633
Autor:
Tony K.T. Lam, Jessica T.Y. Yue
Publikováno v:
J Clin Invest
Developing effective treatments for obesity and related metabolic disease remains a challenge. One logical strategy targets the appetite-regulating actions of gut hormones such as incretins. One of these incretins, glucose-dependent insulinotropic po
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f8a11ceeebbba24b2a98fce2c2fdd2fc
https://europepmc.org/articles/PMC6715352/
https://europepmc.org/articles/PMC6715352/
Publikováno v:
Diabetes. 68
Diabetes is characterized by dysregulated glucose homeostasis that leads to hyperglycemia, due in part to increased hepatic glucose production (GP) and insulin resistance. Excessive levels and/or action of glucocorticoids (GCs) are associated with ob
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1a49501e35421fe0e660bc989cc8145b
https://doi.org/10.2337/db19-104-or
https://doi.org/10.2337/db19-104-or
Publikováno v:
Diabetes. 68
Obesity and diabetes are characterized by dyslipidemia due partly to an overproduction of hepatic triglyceride-rich very-low-density lipoproteins (VLDL-TG). The hypothalamus regulates whole-body lipid homeostasis in rodents but whether extra-hypothal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6cff8f8fdbbeccb6e8b44ee144bed1d5
https://doi.org/10.2337/db19-174-or
https://doi.org/10.2337/db19-174-or
Autor:
Frank A. Duca, Jessica T.Y. Yue
Publikováno v:
Molecular and Cellular Endocrinology. 397:23-33
The ability to properly sense both ingested and circulating nutrients is crucial for the maintenance of metabolic homeostasis. As such, both the gastrointestinal tract and the hypothalamus have demonstrated the capacity to sense and effectively respo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47b67586bb478143e529215b1db6a299
https://doi.org/10.1016/j.mce.2014.09.022
https://doi.org/10.1016/j.mce.2014.09.022
Autor:
Frank A. Duca, Tony K.T. Lam, Beatrice M. Filippi, Mona A. Abraham, Aria Bassiri, Jessica T.Y. Yue
Publikováno v:
Diabetes. 63:892-899
Insulin signaling in the hypothalamus regulates food intake and hepatic glucose production in rodents. Although it is known that insulin also activates insulin receptor in the dorsal vagal complex (DVC) to lower glucose production through an extracel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5af538263f176090f0e6a651a9acb200
https://doi.org/10.2337/db13-1044
https://doi.org/10.2337/db13-1044
Publikováno v:
Reviews in Endocrine and Metabolic Disorders. 14:365-375
The prevalence of the obesity and diabetes epidemic has triggered tremendous research investigating the role of the central nervous system (CNS) in the regulation of food intake, body weight gain and glucose homeostasis. This invited review focuses o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f6d71a165024fe3659a1224a48db5dba
https://doi.org/10.1007/s11154-013-9258-4
https://doi.org/10.1007/s11154-013-9258-4
Autor:
Maureen J. Charron, Madhu Chari, Nikita R Christian, Jessica T.Y. Yue, Beatrice M. Filippi, Clair S. Yang, Carol K.L. Lam, Tony K.T. Lam, Patricia I. Mighiu, Mona A. Abraham
Publikováno v:
Nature Medicine. 19:766-772
Glucagon activates hepatic protein kinase A (PKA) to increase glucose production, but the gluco-stimulatory effect is transient even in the presence of continuous intravenous glucagon infusion. Continuous intravenous infusion of insulin, however, inh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b7d9ea1d8cb7edf6a59a4baabb6a399
https://doi.org/10.1038/nm.3115
https://doi.org/10.1038/nm.3115