Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Jessica T. Pinkham"'
Autor:
Robert S. Jansen, Lungelo Mandyoli, Ryan Hughes, Shoko Wakabayashi, Jessica T. Pinkham, Bruna Selbach, Kristine M. Guinn, Eric J. Rubin, James C. Sacchettini, Kyu Y. Rhee
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
Gene rv3722c is essential for in vitro growth of Mycobacterium tuberculosis, but its function is unclear. Here, Jansen et al. show that Rv3722c is the primary aspartate aminotransferase of this pathogen, mediates nitrogen distribution, and is importa
Externí odkaz:
https://doaj.org/article/0694e638b1514ac5a6f5150aca969407
Autor:
Lungelo Mandyoli, Kristine M. Guinn, Robert S. Jansen, Jessica T. Pinkham, Ryan N. Hughes, Bruna Selbach, Kyu Y. Rhee, James C. Sacchettini, Eric J. Rubin, Shoko Wakabayashi
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
Nature Communications
Nature Communications
Gene rv3722c of Mycobacterium tuberculosis is essential for in vitro growth, and encodes a putative pyridoxal phosphate-binding protein of unknown function. Here we use metabolomic, genetic and structural approaches to show that Rv3722c is the primar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44f73bc34592c63ca7482434829404fc
https://doaj.org/article/0694e638b1514ac5a6f5150aca969407
https://doaj.org/article/0694e638b1514ac5a6f5150aca969407
Autor:
Dirk Schnappinger, Rebecca E Audette, Kristine M. Guinn, Michael Fitzgerald, Michelle Gardner, Carolina Trujillo, Joshua Davis, Joshua B. Wallach, Jessica T. Pinkham, Deborah T. Hung, Nirmalya Bandyopadhyay, Mary Stanley, Natalia Betancourt, Christina Gallo, Megan K. Proulx, Jennifer A McConnell, Christopher M. Sassetti, Sofia Kennedy, Elisabeth Meyer, James Gomez, Kayla Delano, Paula A Pino, Emily LaVerriere, K. G. Papavinasasundaram, Eric S. Lander, Eric J. Rubin, Michael H Serrano-Wu, Emma Office, Caitlin E Moss, Naomi Song, Nadine Ruecker, Thomas R. Ioerger, Israel Da Silva, Matthew Thompson, Christopher Watson, Sabine Ehrt, Shoko Wakabayashi, Brian K. Hubbard, Tomohiko Kawate, Kenan C. Murphy, Rebecca Korn, Raymond M. Nietupski, Eachan O. D. Johnson, Aaron Golas
Publikováno v:
Nature. 571:72-78
New antibiotics are needed to combat rising levels of resistance, with new Mycobacterium tuberculosis (Mtb) drugs having the highest priority. However, conventional whole-cell and biochemical antibiotic screens have failed. Here we develop a strategy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0cb026977411f3d4e740b7e8997fedee
https://doi.org/10.1038/s41586-019-1315-z
https://doi.org/10.1038/s41586-019-1315-z
Autor:
Jessica T. Pinkham, Lungelo Mandyoli, Shoko Wakabayashi, Kristine M. Guinn, Bruna Selbach, Eric J. Rubin, Robert S. Jansen, James C. Sacchettini, Ryan N. Hughes, Kyu Y. Rhee
Organisms are defined by their genomes, yet many distinguishing features of a given organism are encoded by genes that are functionally unannotated.Mycobacterium tuberculosis(Mtb), the leading cause of death due to a single microbe, co-evolved with h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a0498e1867b16b43819c6f02b1dfaf87
https://doi.org/10.1101/784462
https://doi.org/10.1101/784462
Autor:
Laura McPartland, Jessica T. Pinkham, Cristina Landeta, Dana Boyd, Rebecca E Audette, Deepak Balasubramanian, Eric J. Rubin, Taehyun Kim, Ngoc Quang Tran, Brian M. Meehan, Yi-Fan Zhang, Jeremy M. Rock, Stephen Lory, Zaidi Tanweer, Shoko Wakabayashi, Gerald B. Pier, Melody Toosky, Jon Beckwith
Publikováno v:
Molecular microbiology. 111(4)
In bacteria, disulfide bonds confer stability on many proteins exported to the cell envelope or beyond, including bacterial virulence factors. Thus, proteins involved in disulfide bond formation represent good targets for the development of inhibitor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f1f0a1c27c923266ec71c7f1c5b74dec
https://pubmed.ncbi.nlm.nih.gov/30556355
https://pubmed.ncbi.nlm.nih.gov/30556355
Autor:
Mary Stanley, Joshua B. Wallach, Michael H Serrano-Wu, Eachan O. D. Johnson, Paula A Pino, Aaron Golas, Rebecca Korn, Naomi Song, Caitlin E Moss, Eric S. Lander, Jessica T. Pinkham, Joshua Davis, Nadine Ruecker, Dirk Schnappinger, Christina Gallo, Tomohiko Kawate, Nirmalya Bandyopadhyay, Deborah T. Hung, Elisabeth Meyer, Michelle Gardner, Jennifer A McConnell, Thomas R. Ioerger, Carolina Trujillo, Megan K. Proulx, Israel Da Silva, Michael Fitzgerald, Kayla Delano, Emma Office, Kristine M. Guinn, Rebecca E Audette, Christopher Watson, K. G. Papavinasasundaram, Eric J. Rubin, Christopher M. Sassetti, Emily LaVerriere, Brian K. Hubbard, Ray Nietupski, Kenan C. Murphy, James Gomez, Matthew Thompson, Sabine Ehrt, Shoko Wakabayashi, Natalia Betancourt
New antibiotics are needed to combat rising resistance, with new Mycobacterium tuberculosis (Mtb) drugs of highest priority. Conventional whole-cell and biochemical antibiotic screens have failed. We developed a novel strategy termed PROSPECT (PRimar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae1a1b6871077bae65e4d61671b2b402
Autor:
Babak Javid, Flavia Sorrentino, Padraig Deighan, Melody Toosky, Miaomiao Pan, Eric J. Rubin, Nina Jain, Wen Zheng, Jessica T. Pinkham
Publikováno v:
Proceedings of the National Academy of Sciences. 111:1132-1137
Errors are inherent in all biological systems. Errors in protein translation are particularly frequent giving rise to a collection of protein quasi-species, the diversity of which will vary according to the error rate. As mistranslation rates rise, t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67e7826ed364bd27f096e44ff3a4e93d
https://doi.org/10.1073/pnas.1317580111
https://doi.org/10.1073/pnas.1317580111
Publikováno v:
The Journal of Infectious Diseases. 205:1056-1065
Francisella tularensis is a gram-negative coccobacillus that causes tularemia, a highly infectious zoonotic disease. Because of its high infectivity, ease of dissemination, and ability to cause severe disease and death, F. tularensis is designated by
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fcff5ca6f419b4fdf418fe8f742ce46f
https://doi.org/10.1093/infdis/jir620
https://doi.org/10.1093/infdis/jir620
Autor:
Ravikiran M. Raju, Steven P. Gygi, Annie S. Park, Kathryn O'Brien, Jessica T. Pinkham, Dirk Schnappinger, Jun-Rong Wei, German Rehren, Mark P. Jedrychowski, Eric J. Rubin
Publikováno v:
PLoS Pathogens
PLoS Pathogens, Vol 10, Iss 3, p e1003994 (2014)
PLoS Pathogens, Vol 10, Iss 3, p e1003994 (2014)
Unlike most bacterial species, Mycobacterium tuberculosis depends on the Clp proteolysis system for survival even in in vitro conditions. We hypothesized that Clp is required for the physiologic turnover of mycobacterial proteins whose accumulation i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f66b45af78983ac712250c231b163c2
http://europepmc.org/articles/PMC3946367
http://europepmc.org/articles/PMC3946367
Autor:
Dennis L. Kasper, LeeAnn T. Blalock, Tae-Hyun Kim, Jessica T. Pinkham, Shite Sebastian, Robin A. Ross
The O-antigen polymerase of gram-negative bacteria has been difficult to characterize. Herein we report the biochemical and functional characterization of the protein product (Wzy) of the gene annotated as the putative O-antigen polymerase, which is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60d417808f16eca82b5c338403dc64c1
https://europepmc.org/articles/PMC2934651/
https://europepmc.org/articles/PMC2934651/