Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Jessica T, Stieglitz"'
Publikováno v:
ACS Synthetic Biology. 11:3669-3680
Numerous applications of noncanonical amino acids (ncAAs) in basic biology and therapeutic development require efficient protein biosynthesis using an expanded genetic code. However, achieving such incorporation at repurposed stop codons in cells is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db9e5846cc4f450cdaa70fdfe8985a6a
https://doi.org/10.1021/acssynbio.2c00267
https://doi.org/10.1021/acssynbio.2c00267
Publikováno v:
ACS Synth Biol
Archaeal pyrrolysyl-tRNA synthetases (PylRSs) have been used to genetically encode over 200 distinct noncanonical amino acids (ncAAs) in proteins in E. coli and mammalian cells. This vastly expands the range of chemical functionality accessible withi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dac58a276c72bac336a422f90d5b17c6
https://doi.org/10.1021/acssynbio.2c00001
https://doi.org/10.1021/acssynbio.2c00001
Publikováno v:
ACS synthetic biology. 11(7)
Protein expression with genetically encoded noncanonical amino acids (ncAAs) benefits a broad range of applications, from the discovery of biological therapeutics to fundamental biological studies. A major factor limiting the use of ncAAs is the lack
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c453d550a0b7ee2181b8b32ff674153e
https://pubmed.ncbi.nlm.nih.gov/35793554
https://pubmed.ncbi.nlm.nih.gov/35793554
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 2491
Yeast display has been used to advance many critical research areas, including the discovery of unique protein binders and biological therapeutics. In parallel, noncanonical amino acids (ncAAs) have been used to tailor antibody-drug conjugates and en
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::eeb2164f0b75495e97c05eee987b3ed1
https://pubmed.ncbi.nlm.nih.gov/35482204
https://pubmed.ncbi.nlm.nih.gov/35482204
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 2394
Genetic code expansion has allowed for extraordinary advances in enhancing protein chemical diversity and functionality, but there remains a critical need for understanding and engineering genetic code expansion systems for improved efficiency. Incor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::16d993388acd040cfdd6d81a5eb72c94
https://pubmed.ncbi.nlm.nih.gov/35094338
https://pubmed.ncbi.nlm.nih.gov/35094338
Publikováno v:
Methods in Molecular Biology ISBN: 9781071622841
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9987a36ce29bcc5964c4843efbf5e853
https://doi.org/10.1007/978-1-0716-2285-8_23
https://doi.org/10.1007/978-1-0716-2285-8_23
Publikováno v:
Methods in Molecular Biology ISBN: 9781071618103
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::89b88f511498298f240011c21e1bd975
https://doi.org/10.1007/978-1-0716-1811-0_21
https://doi.org/10.1007/978-1-0716-1811-0_21