Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Jessica Spires"'
Publikováno v:
Pharmaceutics, Vol 16, Iss 7, p 914 (2024)
The development of generic ophthalmic drug products with complex formulations is challenging due to the complexity of the ocular system and a lack of sensitive testing to evaluate the interplay of its physiology with ophthalmic drugs. New methods are
Externí odkaz:
https://doaj.org/article/8095b13d760d4754a8fd2e1cacdf15b1
Autor:
Eleftheria Tsakalozou, Khondoker Alam, Priyanka Ghosh, Jessica Spires, Sebastian Polak, Lanyan Fang, Srinivasa Sammeta, Ping Zhao, Sumit Arora, Sam G. Raney
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology, Vol 12, Iss 5, Pp 575-584 (2023)
Abstract The development of a generic drug product involves demonstrating that there is no significant difference in the rate and extent to which the active ingredient becomes available at the site of action, relative to the reference listed drug pro
Externí odkaz:
https://doaj.org/article/a95d06aa883441cea4bb45e8923b51a2
Autor:
William A. Murphy, Jeffry Adiwidjaja, Noora Sjöstedt, Kyunghee Yang, James J. Beaudoin, Jessica Spires, Scott Q. Siler, Sibylle Neuhoff, Kim L.R. Brouwer
Publikováno v:
Clinical Pharmacology & Therapeutics. 113:275-297
Nonalcoholic fatty liver disease (NAFLD), representing a clinical spectrum ranging from nonalcoholic fatty liver (NAFL) to nonalcoholic steatohepatitis (NASH), is rapidly evolving into a global pandemic. Patients with NAFLD are burdened with high rat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db0f95ca9338677680f2628feda23b53
https://doi.org/10.1002/cpt.2614
https://doi.org/10.1002/cpt.2614
Autor:
Eleftheria Tsakalozou, Khondoker Alam, Priyanka Ghosh, Jessica Spires, Sebastian Polak, Lanyan Fang, Srinivasa Sammeta, Ping Zhao, Sumit Arora, Sam G. Raney
Publikováno v:
CPT: pharmacometricssystems pharmacologyREFERENCES.
The development of a generic drug product involves demonstrating that there is no significant difference in the rate and extent to which the active ingredient becomes available at the site of action, relative to the reference listed drug product. Thi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6486ca0a523b06ec1b5bc94fd31651f8
https://pubmed.ncbi.nlm.nih.gov/36456539
https://pubmed.ncbi.nlm.nih.gov/36456539
Autor:
Sharron Stewart, Eleftheria Tsakalozou, Maxime Le Merdy, Murali K. Matta, Andrew Babiskin, Liang Zhao, Jianghong Fan, Suresh Narayanasamy, Lei Zhang, Ashok Chockalingam, Jessica Spires, Darby Kozak, Vikram Patel, Stephanie Choi, Lin Xu, Rodney Rouse, Robert Lionberger, Michael B. Bolger, Viera Lukacova
Publikováno v:
The AAPS journal. 21(4)
Developing mathematical models to predict changes in ocular bioavailability and pharmacokinetics due to differences in the physicochemical properties of complex topical ophthalmic suspension formulations is important in drug product development and r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d37467bd86299ed0bf4486feb5cec50
https://pubmed.ncbi.nlm.nih.gov/31111305
https://pubmed.ncbi.nlm.nih.gov/31111305
Autor:
Rob C I, Wüst, James R, McDonald, Yi, Sun, Brian S, Ferguson, Matthew J, Rogatzki, Jessica, Spires, John M, Kowalchuk, L Bruce, Gladden, Harry B, Rossiter
Publikováno v:
The Journal of physiology. 592(8)
Oxygen uptake kinetics (τVO2) are slowed when exercise is initiated from a raised metabolic rate. Whether this reflects the recruitment of muscle fibres differing in oxidative capacity, or slowed blood flow (Q) kinetics is unclear. This study determ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::acd88ade8cac5c8594a20c89bd3405df
https://pubmed.ncbi.nlm.nih.gov/24469073
https://pubmed.ncbi.nlm.nih.gov/24469073
Autor:
Nicola Lai, Matthew L. Goodwin, L. Bruce Gladden, Jessica Spires, Bruno Grassi, Gerald M. Saidel
With current techniques, experimental measurements alone cannot characterize the effects of oxygen blood-tissue diffusion on muscle oxygen uptake (V̇o2) kinetics in contracting skeletal muscle. To complement experimental studies, a computational mod
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f467821e13f41a0565ed6501d6c026bf
https://europepmc.org/articles/PMC3763029/
https://europepmc.org/articles/PMC3763029/
Autor:
John M. Kowalchuk, L. Bruce Gladden, Rob C. I. Wüst, Brian S. Ferguson, Harry B. Rossiter, James R. McDonald, Jessica Spires, Yi Sun, Matthew J. Rogatzki
Publikováno v:
The FASEB Journal. 26
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1f350013d8a7f2846cf404e46bb5e3b3
https://doi.org/10.1096/fasebj.26.1_supplement.1142.28
https://doi.org/10.1096/fasebj.26.1_supplement.1142.28
Publikováno v:
Oxygen Transport to Tissue XXXII ISBN: 9781441977557
The quantitative contributions of hemoglobin and myoglobin oxygenation in skeletal muscle depend on physiological factors, especially muscle blood flow (Q( m )) and capillary permeability-surface area (PS). Near-infrared spectroscopy (NIRS) can be us
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f86ac5e534513a29e9cfd729cab621df
https://doi.org/10.1007/978-1-4419-7756-4_47
https://doi.org/10.1007/978-1-4419-7756-4_47
Publikováno v:
The FASEB Journal. 24
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cb32661e3d15a4174fb44e587de1a6a3
https://doi.org/10.1096/fasebj.24.1_supplement.1065.7
https://doi.org/10.1096/fasebj.24.1_supplement.1065.7