Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Jessica Sacks"'
Autor:
Robert N Helsley, Venkateshwari Varadharajan, Amanda L Brown, Anthony D Gromovsky, Rebecca C Schugar, Iyappan Ramachandiran, Kevin Fung, Mohammad Nasser Kabbany, Rakhee Banerjee, Chase K Neumann, Chelsea Finney, Preeti Pathak, Danny Orabi, Lucas J Osborn, William Massey, Renliang Zhang, Anagha Kadam, Brian E Sansbury, Calvin Pan, Jessica Sacks, Richard G Lee, Rosanne M Crooke, Mark J Graham, Madeleine E Lemieux, Valentin Gogonea, John P Kirwan, Daniela S Allende, Mete Civelek, Paul L Fox, Lawrence L Rudel, Aldons J Lusis, Matthew Spite, J Mark Brown
Publikováno v:
eLife, Vol 8 (2019)
Recent studies have identified a genetic variant rs641738 near two genes encoding membrane bound O-acyltransferase domain-containing 7 (MBOAT7) and transmembrane channel-like 4 (TMC4) that associate with increased risk of non-alcoholic fatty liver di
Externí odkaz:
https://doaj.org/article/f9448bea0b9e426ea0147da3a9110b3e
Autor:
Caleb C. Lord, Daniel Ferguson, Gwynneth Thomas, Amanda L. Brown, Rebecca C. Schugar, Amy Burrows, Anthony D. Gromovsky, Jenna Betters, Chase Neumann, Jessica Sacks, Stephanie Marshall, Russell Watts, Martina Schweiger, Richard G. Lee, Rosanne M. Crooke, Mark J. Graham, Justin D. Lathia, Takuya F. Sakaguchi, Richard Lehner, Guenter Haemmerle, Rudolf Zechner, J. Mark Brown
Publikováno v:
Cell Reports, Vol 16, Iss 4, Pp 939-949 (2016)
Adipose triglyceride lipase (ATGL) and comparative gene identification 58 (CGI-58) are critical regulators of triacylglycerol (TAG) turnover. CGI-58 is thought to regulate TAG mobilization by stimulating the enzymatic activity of ATGL. However, it is
Externí odkaz:
https://doaj.org/article/d66246b7b7b944b08b3d090febecf391
Autor:
Manya Warrier, Diana M. Shih, Amy C. Burrows, Daniel Ferguson, Anthony D. Gromovsky, Amanda L. Brown, Stephanie Marshall, Allison McDaniel, Rebecca C. Schugar, Zeneng Wang, Jessica Sacks, Xin Rong, Thomas de Aguiar Vallim, Jeff Chou, Pavlina T. Ivanova, David S. Myers, H. Alex Brown, Richard G. Lee, Rosanne M. Crooke, Mark J. Graham, Xiuli Liu, Paolo Parini, Peter Tontonoz, Aldon J. Lusis, Stanley L. Hazen, Ryan E. Temel, J. Mark Brown
Publikováno v:
Cell Reports, Vol 10, Iss 3, Pp 326-338 (2015)
Circulating levels of the gut microbe-derived metabolite trimethylamine-N-oxide (TMAO) have recently been linked to cardiovascular disease (CVD) risk. Here, we performed transcriptional profiling in mouse models of altered reverse cholesterol transpo
Externí odkaz:
https://doaj.org/article/a4273ef0fd5b4cb38f7e399803e887fb
Autor:
Madeleine Goeritzer, Stefanie Schlager, Branislav Radovic, Corina T. Madreiter, Silvia Rainer, Gwynneth Thomas, Caleb C. Lord, Jessica Sacks, Amanda L. Brown, Nemanja Vujic, Sascha Obrowsky, Vinay Sachdev, Dagmar Kolb, Prakash G. Chandak, Wolfgang F. Graier, Wolfgang Sattler, J. Mark Brown, Dagmar Kratky
Publikováno v:
Journal of Lipid Research, Vol 55, Iss 12, Pp 2562-2575 (2014)
Cellular TG stores are efficiently hydrolyzed by adipose TG lipase (ATGL). Its coactivator comparative gene identification-58 (CGI-58) strongly increases ATGL-mediated TG catabolism in cell culture experiments. To investigate the consequences of CGI-
Externí odkaz:
https://doaj.org/article/6c08cfbd5a4e4241921cb0bb76dbc68b
Publikováno v:
Cleveland Clinic Journal of Medicine. 84:S15-S21
Exercise is typically one of the first management strategies advised for patients newly diagnosed with type 2 diabetes. Together with diet and behavior modification, exercise is an essential component of all diabetes and obesity prevention and lifest
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b3e25832546aa179df2305314ea79971
https://doi.org/10.3949/ccjm.84.s1.03
https://doi.org/10.3949/ccjm.84.s1.03
Autor:
Dalia Halawani, Jie Chen, Sara C. Kozma, Arnab China, George Thomas, Paul L. Fox, J. Mark Brown, Jie Jia, Xiaoxia Li, Alka A. Potdar, Abul Arif, Jessica Sacks, Kommireddy Vasu, Fulvia Terenzi
Publikováno v:
Nature
Recercat. Dipósit de la Recerca de Catalunya
instname
Dipòsit Digital de la UB
Universidad de Barcelona
Recercat. Dipósit de la Recerca de Catalunya
instname
Dipòsit Digital de la UB
Universidad de Barcelona
Metabolic pathways that contribute to adiposity and ageing are activated by the mammalian target of rapamycin complex 1 (mTORC1) and p70 ribosomal protein S6 kinase 1 (S6K1) axis. However, known mTORC1-S6K1 targets do not account for observed loss-of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd26c909141f93cfe1cb0ac698dc9267
http://europepmc.org/articles/PMC5480610
http://europepmc.org/articles/PMC5480610
Autor:
Robert N. Helsley, Chelsea Finney, Amanda L. Brown, Kevin Fung, Anthony D. Gromovsky, Preeti Pathak, Mohammad Nasser Kabbany, Daniela S. Allende, Jessica Sacks, Danny Orabi, Rosanne M. Crooke, Paul L. Fox, Calvin Pan, John P. Kirwan, Rakhee Banerjee, J. Mark Brown, Valentin Gogonea, Venkateshwari Varadharajan, Richard G. Lee, Mark J. Graham, Chase K Neumann, Mete Civelek, Matthew Spite, Lawrence L. Rudel, Brian E. Sansbury, Madeleine E. Lemieux, Aldons J. Lusis, Lucas J Osborn, Iyappan Ramachandiran, Anagha Kadam, Renliang Zhang, William Massey, Rebecca C. Schugar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::85d06fea06933080f7d1960525358ce9
https://doi.org/10.7554/elife.49882.037
https://doi.org/10.7554/elife.49882.037
Autor:
Iyappan Ramachandiran, Paul L. Fox, Aldons J. Lusis, Mohammad Nasser Kabbany, Mete Civelek, Mark J. Graham, Chelsea Finney, Lawrence L. Rudel, Kevin Fung, Preeti Pathak, Danny Orabi, Brian E. Sansbury, Madeleine E. Lemieux, Richard G. Lee, Rosanne M. Crooke, Calvin Pan, Valentin Gogonea, Amanda L. Brown, Matthew Spite, John P. Kirwan, Rakhee Banerjee, Venkateshwari Varadharajan, Chase K Neumann, Lucas J Osborn, Daniela S. Allende, Jessica Sacks, Renliang Zhang, William Massey, Anthony D. Gromovsky, Rebecca C. Schugar, Anagha Kadam, J. Mark Brown, Robert N. Helsley
Publikováno v:
eLife
eLife, Vol 8 (2019)
eLife, Vol 8 (2019)
Recent studies have identified a genetic variant rs641738 near two genes encoding membrane bound O-acyltransferase domain-containing 7 (MBOAT7) and transmembrane channel-like 4 (TMC4) that associate with increased risk of non-alcoholic fatty liver di
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ded16f4ff76146423a122b4c7688cfc9
http://europepmc.org/articles/PMC6850774
http://europepmc.org/articles/PMC6850774
Autor:
Martina Schweiger, Chase K Neumann, Justin D. Lathia, Russell Watts, Rudolf Zechner, Richard G. Lee, Guenter Haemmerle, Caleb C. Lord, J. Mark Brown, Rosanne M. Crooke, Jenna L. Betters, Amy C. Burrows, Takuya F. Sakaguchi, Anthony D. Gromovsky, Jessica Sacks, Gwynneth Thomas, Stephanie M. Marshall, Amanda L. Brown, Richard Lehner, Mark J. Graham, Rebecca C. Schugar, Daniel Ferguson
Publikováno v:
Cell Reports, Vol 16, Iss 4, Pp 939-949 (2016)
SummaryAdipose triglyceride lipase (ATGL) and comparative gene identification 58 (CGI-58) are critical regulators of triacylglycerol (TAG) turnover. CGI-58 is thought to regulate TAG mobilization by stimulating the enzymatic activity of ATGL. However
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d16cdbe9d6abf0336a67f13692b946a7
https://doi.org/10.1016/j.celrep.2016.06.049
https://doi.org/10.1016/j.celrep.2016.06.049
Publikováno v:
Diabetes. 67
Mitochondrial uncoupling was one of the earliest pharmacologic approaches to the treatment of obesity-related diseases. However, low mitochondrial specificity and negative off-target effects limited the viability of such agents. BAM15 is a small mole
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::812ebd380463d75c221625208941f025
https://doi.org/10.2337/db18-1778-p
https://doi.org/10.2337/db18-1778-p