An Implementation Strategy to Develop Sustainable Surveillance Activities Through Adoption of a Target Operating Model

Autor: Natalie K. Lee, Miles A. Stewart, Jessica S. Dymond, Sheri L. Lewis

Publikováno v: Frontiers in Public Health, Vol 10 (2022)

The increasing threat of emerging and re-emerging pathogens calls for a shared vision toward developing and maintaining global surveillance mechanisms to enable rapid characterization of pathogens, a foundational requirement for effective outbreak re

Externí odkaz: https://doaj.org/article/4ab2b38107f04e9394adeade05fb5106

Design of a synthetic yeast genome

Autor: Leslie A. Mitchell, Jef D. Boeke, Cheng Lai Victor Huang, Dongwon Lee, Sarah M. Richardson, Joel S. Bader, Giovanni Stracquadanio, Jessica S. Dymond, Kun Yang, Yizhi Cai, Srinivasan Chandrasegaran, James E. DiCarlo

Publikováno v: Richardson, S M, Mitchell, L A, Stracquadanio, G, Yang, K, Dymond, J S, DiCarlo, J E, Lee, D, Huang, C L V, Chandrasegaran, S, Cai, Y, Boeke, J D & Bader, J S 2017, ' Design of a synthetic yeast genome ', Science, vol. 355, no. 6329, pp. 1040-1044 . https://doi.org/10.1126/science.aaf4557

We describe complete design of a synthetic eukaryotic genome, Sc2.0, a highly modified Saccharomyces cerevisiae genome reduced in size by nearly 8%, with 1.1 megabases of the synthetic genome deleted, inserted, or altered. Sc2.0 chromosome design was

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c4c29df8dbe7906cc7992b80324b38cf
https://doi.org/10.1126/science.aaf4557

SCRaMbLE generates designed combinatorial stochastic diversity in synthetic chromosomes

Autor: Xun Xu, Yongfen Zhang, Jian Wang, Joel S. Bader, Tai Chen, Jef D. Boeke, Huanming Yang, Yun Wang, Giovanni Stracquadanio, Xiaofan Zeng, Yaxin Xue, Jianhui Gong, Yingrui Li, Leslie A. Mitchell, Jun Wang, Qiang Feng, Kun Yang, Yizhi Cai, Jessica S. Dymond, Kang Kang, Yue Shen

Publikováno v: Shen, Y, Stracquadanio, G, Wang, Y, Yang, K, Mitchell, L A, Xue, Y, Cai, Y, Chen, T, Dymond, J S, Kang, K, Gong, J, Zeng, X, Zhang, Y, Li, Y, Feng, Q, Xu, X, Wang, J, Wang, J, Yang, H, Boeke, J D & Bader, J S 2016, ' SCRaMbLE generates designed combinatorial stochastic diversity in synthetic chromosomes ', Genome Research, vol. 26, no. 1, pp. 36-49 . https://doi.org/10.1101/gr.193433.115
Shen, Y, Stracquadanio, G, Wang, Y, Yang, K, Mitchell, L A, Xue, Y, Cai, Y, Chen, T, Dymond, J S, Kang, K, Gong, J, Zeng, X, Zhang, Y, Li, Y, Feng, Q, Xu, X, Wang, J, Wang, J, Yang, H, Boeke, J D & Bader, J S 2016, ' SCRaMbLE generates designed combinatorial stochastic diversity in synthetic chromosomes ', Genome research, vol. 26, no. 1, pp. 36-49 . https://doi.org/10.1101/gr.193433.115

Synthetic chromosome rearrangement and modification by loxP-mediated evolution (SCRaMbLE) generates combinatorial genomic diversity through rearrangements at designed recombinase sites. We applied SCRaMbLE to yeast synthetic chromosome arm synIXR (43

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cad0051b5fa36f5fec47375fcb2d6085
https://www.pure.ed.ac.uk/ws/files/24355844/36.full.pdf

Synthetic chromosome arms function in yeast and generate phenotypic diversity by design

Autor: Jessica S. Dymond, Joy Wu Schwerzmann, Junbiao Dai, William Jeremy Blake, Srinivasan Chandrasegaran, Daniel E. Gottschling, Candice E. Coombes, Annabel C. Boeke, Narayana Annaluru, Héloïse Muller, Jef D. Boeke, Joel S. Bader, Sarah M. Richardson, Derek L. Lindstrom, Timothy D. Babatz

Publikováno v: Nature. 477:471-476

Recent advances in DNA synthesis technology have enabled the construction of novel genetic pathways and genomic elements, furthering our understanding of system-level phenomena. The ability to synthesize large segments of DNA allows the engineering o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df86521fcd1a1e02c7e5530ba60ec068
https://doi.org/10.1038/nature10403

Erratum for the Research Article: 'Total Synthesis of a Functional Designer Eukaryotic Chromosome' by N. Annaluru, H. Muller, L. A. Mitchell, S. Ramalingam, G. Stracquadanio, S. M. Richardson, J. S. Dymond, Z. Kuang, L. Z. Scheifele, E. M. Cooper, Y. Cai, K. Zeller, N. Agmon, J. S. Han, M. Hadjithomas, J. Tullman, K. Caravelli, K. Cirelli, Z. Guo, V. London, A. Yeluru, S. Murugan, K. Kandavelou, N. Agier, G. Fischer, K. Yang, J. A. Martin, M. Bilgel, P. Bohutskyi, K. M. Boulier, B. J. Capaldo, J. Chang, K. Charoen, W. J. Choi, P. Deng, J. E. DiCarlo, J. Doong, J. Dunn, J. I. Feinberg, C. Fernandez, C. E. Floria, D. Gladowski, P. Hadidi, I. Ishizuka, J. Jabbari, C. Y. L. Lau, P. A. Lee, S. Li, D. Lin, M. E. Linder, J. Ling, J. Liu, J. Liu, M. London, H. Ma, J. Mao, J. E. McDade, A. McMillan, A. M. Moore, W. C. Oh, Y. Ouyang, R. Patel, M. Paul, L. C. Paulsen, J. Qiu, A. Rhee, M. G. Rubashkin, I. Y. Soh, N. E. Sotuyo, V. Srinivas, A. Suarez, A. Wong, R. Wong, W. R. Xie, Y. Xu, A. T. Yu, R. Koszul, J. S. Bader, J. D. Boeke, S. Chandrasegaran

Autor: Apurva Yeluru, Christopher Fernandez, Remus S. Wong, Jaime Liu, Jason I. Feinberg, Jessica S. Dymond, Jeffrey S. Han, Joy Chang, Sivaprakash Ramalingam, Yizhi Cai, Kristin M. Boulier, Zheng Kuang, Katrina Caravelli, Mariya London, Yu Ouyang, David Gladowski, Kristie Charoen, Nicolas Agier, Matthew G. Rubashkin, Charlotte E. Floria, Henry Ma, Karthikeyan Kandavelou, Isabel E. Ishizuka, Jonathan P. Ling, Won Chan Oh, Kun Yang, Calvin Y. L. Lau, Jessica E. McDade, Leslie A. Mitchell, Laura C. Paulsen, Héloïse Muller, Denise Lin, Romain Koszul, Neta Agmon, Jessica Mao, Judy Qiu, Sarah M. Richardson, Kimberly M. Cirelli, Lisa Z. Scheifele, Brian J. Capaldo, Zheyuan Guo, Marina Paul, Wei Xie, Matthias E. Linder, Jef D. Boeke, Joel S. Bader, Allison Suarez, Sean Li, Karen I. Zeller, Andrew D. Wong, Pavlo Bohutskyi, Gilles Fischer, Alex Rhee, Pasha Hadidi, Pablo A. Lee, Eric M. Cooper, Peter Deng, Venkatesh Srinivas, Ina Y. Soh, J. Andrew Martin, Aaron M. Moore, Allen T. Yu, Viktoriya London, Woo Jin Choi, Yijie Xu, Alexandra McMillan, James E. DiCarlo, Jonathan Liu, Michalis Hadjithomas, Murat Bilgel, Jessilyn Dunn, Srinivasan Chandrasegaran, Javaneh Jabbari, Ruchi Patel, Sindurathy Murugan, Judy Doong, Nathaniel E. Sotuyo, Narayana Annaluru, Jennifer Tullman, Giovanni Stracquadanio

Publikováno v: Science. 344

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d6b5a4c64ecd3391c0f5b3e16628139f
https://doi.org/10.1126/science.1254596