Zobrazeno 1 - 10
of 68
pro vyhledávání: '"Jessica S Fortin"'
Publikováno v:
Biochemistry and Biophysics Reports, Vol 39, Iss , Pp 101775- (2024)
Externí odkaz:
https://doaj.org/article/a97bbcd689a4463d8d7d98850f6f0221
Publikováno v:
Biochemistry and Biophysics Reports, Vol 39, Iss , Pp 101810- (2024)
Alpha-synuclein (α-syn) aggregation plays a critical role in the pathogenicity of Parkinson's Disease (PD). This study aims to evaluate the aggregation propensity of α-syn fragment peptides designed using the variability found in humans and animals
Externí odkaz:
https://doaj.org/article/26834cd41672433e9d1c10ef63c1e9d2
Autor:
Jessica S Fortin, Alexandre Patenaude, Rena G Deschesnes, Marie-France Côté, Eric Petitclerc, René C.-Gaudreault
Publikováno v:
Journal of Pharmacy & Pharmaceutical Sciences, Vol 13, Iss 2 (2010)
PURPOSE. We investigated the involvement of MAPK signaling in the cell death mechanisms of classical microtubule interfering agents (MIA) and aryl-3-(2-chloroethyl)ureas (CEU) acting as antimitotics, along with CEU that don’t affect directly microt
Externí odkaz:
https://doaj.org/article/53a1881ce0b84ba29a05b27c0efbe9e2
Autor:
Susantha K. Ganegamage, Eduardo Ramirez, Heba Alnakhala, Arati Tripathi, Cuong Calvin Duc Nguyen, Ashique Zami, Raluca Ostafe, Shiliang Tian, Ulf Dettmer, Jessica S. Fortin
Publikováno v:
ACS Omega, Vol 9, Iss 1, Pp 1216-1229 (2023)
Externí odkaz:
https://doaj.org/article/91f413a48d6b44b08c7e895c9453da6d
Publikováno v:
Veterinary Quarterly, Vol 43, Iss 1, Pp 1-8 (2023)
AbstractAA amyloidosis, characterized by the misfolding of serum amyloid A (SAA) protein, is the most common amyloid protein disorder across multiple species. SAA is a positive-acute phase protein synthesized by the liver in response to inflammation
Externí odkaz:
https://doaj.org/article/081be04c4b1c4c4d8387b2e68ff7a314
Publikováno v:
Veterinary Quarterly, Vol 43, Iss 1, Pp 1-12 (2023)
AbstractBackground Type 2 diabetes (T2D) is a health concern for both humans and cats, with cases rising over the past decade. Around 70% of patients from either species exhibit pancreatic aggregates of islet amyloid polypeptide (IAPP), a protein tha
Externí odkaz:
https://doaj.org/article/c57fda51c48648fdb1583a23a34ac368
Autor:
Eduardo Ramirez, Sehong Min, Susantha K. Ganegamage, Kazuma Shimanaka, Magaly Guzman Sosa, Ulf Dettmer, Jean-Christophe Rochet, Jessica S. Fortin
Publikováno v:
Results in Chemistry, Vol 5, Iss , Pp 100938- (2023)
Alzheimer’s disease (AD) is a multifactorial, chronic neurodegenerative disease characterized by the presence of extracellular β-amyloid (Aβ) plaques, intraneuronal neurofibrillary tangles (NFTs), activated microglial cells, and an inflammatory s
Externí odkaz:
https://doaj.org/article/d6777e6966384829a372fdced7a39554
Autor:
Jessica S. Fortin, Ashley A. Hetak, Kelsey E. Duggan, Caroline M. Burglass, Hailey B. Penticoff, Harold C. Schott
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
Abstract Equine pituitary pars intermedia dysfunction (PPID) is a common endocrine disease of aged horses that shows a similar pathophysiology as Parkinson’s Disease (PD) with increased levels of α-synuclein (α-syn). While α-syn is thought to pl
Externí odkaz:
https://doaj.org/article/31b331f9eae4475cb801f4fb07245979
Publikováno v:
Biochemistry and Biophysics Reports, Vol 31, Iss , Pp 101284- (2022)
AA amyloidosis is the result of overproduction and aberrant processing of acute-phase serum amyloid A1 (SAA1) by hepatocytes. Proteolytic cleavage of SAA1 is believed to play a central role in AA amyloid formation. The SAA1 protein undergoes a cleava
Externí odkaz:
https://doaj.org/article/89cab0461dd14cdfb9a8a73ae7b7e337
Autor:
Jessica S. Fortin, Chady H. Hakim, Scott Korte, N. Nora Yang, Scott D. Fitzgerald, Gayle C. Johnson, Bruce F. Smith, Dongsheng Duan
Publikováno v:
Veterinary Medicine and Science, Vol 7, Iss 3, Pp 654-659 (2021)
Abstract The University of Missouri (MU) has established a colony of dystrophin‐deficient dogs with a mixed breed background to mirror the variable pathologic effects of dystrophinopathies between persons of a given kindred to further the understan
Externí odkaz:
https://doaj.org/article/351578939fd147a5a0fbbf1e34e6eb7d