Zobrazeno 1 - 10
of 89
pro vyhledávání: '"Jessica S Blackburn"'
Autor:
Caroline N Smith, Kyle Kihn, Zachary A Williamson, K Martin Chow, Louis B Hersh, Konstantin V Korotkov, Daniel Deredge, Jessica S Blackburn
Publikováno v:
PLoS ONE, Vol 18, Iss 5, p e0285964 (2023)
Phosphatase of Regenerating Liver-3 (PRL-3) is associated with cancer progression and metastasis. The mechanisms that drive PRL-3's oncogenic functions are not well understood, partly due to a lack of research tools available to study this protein. W
Externí odkaz:
https://doaj.org/article/f688ec8b8a0a4c2b94b6ee1357dbd491
Autor:
Finola E Moore, Deepak Reyon, Jeffry D Sander, Sarah A Martinez, Jessica S Blackburn, Cyd Khayter, Cherie L Ramirez, J Keith Joung, David M Langenau
Publikováno v:
PLoS ONE, Vol 7, Iss 5, p e37877 (2012)
Zinc Finger Nucleases (ZFNs) made by Context-Dependent Assembly (CoDA) and Transcription Activator-Like Effector Nucleases (TALENs) provide robust and user-friendly technologies for efficiently inactivating genes in zebrafish. These designer nuclease
Externí odkaz:
https://doaj.org/article/06be4b11a7854f728ad26d2a7669fc64
Autor:
Shilpa Sampathi, Yelena Chernyavskaya, Meghan G. Haney, L. Henry Moore, Isabel A. Snyder, Anna H. Cox, Brittany L. Fuller, Tamara J. Taylor, Donglin Yan, Tom C. Badgett, Jessica S. Blackburn
Publikováno v:
Frontiers in Oncology, Vol 12 (2022)
BackgroundAcute Lymphoblastic Leukemia (ALL) is the most common pediatric cancer, and patients with relapsed ALL have a poor prognosis. Detection of ALL blasts remaining at the end of treatment, or minimal residual disease (MRD), and spread of ALL in
Externí odkaz:
https://doaj.org/article/88b631c58e034e68bd52d1b457e89b2d
Autor:
Dylan R. Rivas, Mark Vincent C. Dela Cerna, Caroline N. Smith, Shilpa Sampathi, Blaine G. Patty, Donghan Lee, Jessica S. Blackburn
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
Abstract Protein tyrosine phosphatase 4A3 (PTP4A3 or PRL-3) is highly expressed in a variety of cancers, where it promotes tumor cell migration and metastasis leading to poor prognosis. Despite its clinical significance, small molecule inhibitors of
Externí odkaz:
https://doaj.org/article/89ae12dcbcca49f7a9c1ef19ce93ee16
Publikováno v:
STAR Protocols, Vol 2, Iss 2, Pp 100433- (2021)
Summary: Dysregulation of Wnt signaling is a hallmark of many cancers, and the development of effective, non-toxic small-molecule Wnt inhibitors is desirable. Off-target toxicities of new compounds are typically tested in mouse models, which is both
Externí odkaz:
https://doaj.org/article/ecc3192cb4924fb59bad8e553b0e444e
Autor:
Richard J. Mitchell, Sarah M. Kriger, Alexander D. Fenton, Dmytro Havrylyuk, Ankit Pandeya, Yang Sun, Tami Smith, Jason E. DeRouchey, Jason M. Unrine, Viral Oza, Jessica S. Blackburn, Yinan Wei, David K. Heidary, Edith C. Glazer
Publikováno v:
RSC Chemical Biology. 4:344-353
Phenanthriplatin forms DNA mono-adducts and induces ribosome biogenesis stress. Using a semi-rational strategy, Ru(ii) complexes were created that act as biological mimics of phenanthriplatin with improved properties.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d858fd26c8b8445e3028892a060bcf52
https://doi.org/10.1039/d2cb00247g
https://doi.org/10.1039/d2cb00247g
Autor:
Wen Zhang, Vitaliy M. Sviripa, Yanqi Xie, Tianxin Yu, Meghan G. Haney, Jessica S. Blackburn, Charles A. Adeniran, Chang-Guo Zhan, David S. Watt, Chunming Liu
Publikováno v:
iScience, Vol 23, Iss 12, Pp 101795- (2020)
Summary: Aberrant activation of Wnt signaling triggered by mutations in either Adenomatous Polyposis Coli (APC) or CTNNB1 (β-catenin) is a hallmark of colorectal cancers (CRC). As part of a program to develop epigenetic regulators for cancer therapy
Externí odkaz:
https://doaj.org/article/c10f7711030744a6997f7f1ff875703c
Autor:
David M. Langenau, Graham Dellaire, Raul Mostoslavsky, Richard A. Young, A. Thomas Look, Wilhelm Haas, Marjorie A. Oettinger, John M. Asara, Ruslan I. Sadreyev, Lewis B. Silverman, Kimberly Stegmaier, Alejandro Gutierrez, Khalid Shah, Deepak Bhere, Mattia Lion, Myriam Boukhali, Esha Jain, Manon de Waard, Debra Toiber, Gabriela Alexe, Aleksey Molodtsov, Nouran S. Abdelfattah, Marc Mansour, Yuka Namiki, Brian J. Abraham, Jessica S. Blackburn, Marina Theodorou, Barbara Martinez-Pastor, Jordan Pinder, Riadh Lobbardi
Table S1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::255793326b8fa5a626788734c825f054
https://doi.org/10.1158/2159-8290.22532231
https://doi.org/10.1158/2159-8290.22532231
Autor:
David M. Langenau, Graham Dellaire, Raul Mostoslavsky, Richard A. Young, A. Thomas Look, Wilhelm Haas, Marjorie A. Oettinger, John M. Asara, Ruslan I. Sadreyev, Lewis B. Silverman, Kimberly Stegmaier, Alejandro Gutierrez, Khalid Shah, Deepak Bhere, Mattia Lion, Myriam Boukhali, Esha Jain, Manon de Waard, Debra Toiber, Gabriela Alexe, Aleksey Molodtsov, Nouran S. Abdelfattah, Marc Mansour, Yuka Namiki, Brian J. Abraham, Jessica S. Blackburn, Marina Theodorou, Barbara Martinez-Pastor, Jordan Pinder, Riadh Lobbardi
Supplementary Data
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d38cf5f62436e4a13b0c92f5230c769
https://doi.org/10.1158/2159-8290.22532234.v1
https://doi.org/10.1158/2159-8290.22532234.v1
Autor:
Qin Tang, John C. Moore, Myron S. Ignatius, Inês M. Tenente, Madeline N. Hayes, Elaine G. Garcia, Nora Torres Yordán, Caitlin Bourque, Shuning He, Jessica S. Blackburn, A. Thomas Look, Yariv Houvras, David M. Langenau
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-10 (2016)
Direct visualisation of heterogeneous cell populations in live animals has been challenging. Here, the authors optimize cell transplantation into optically clear immune-deficient zebrafish, and use intravital imaging to track and to assess functional
Externí odkaz:
https://doaj.org/article/0c91eceedf1044eca16d9570f08e6ec0