Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Jessica Rodgers"'
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 16 (2022)
Light has a profound impact on mammalian physiology and behavior. Intrinsically photosensitive retinal ganglion cells (ipRGCs) express the photopigment melanopsin, rendering them sensitive to light, and are involved in both image-forming vision and n
Externí odkaz:
https://doaj.org/article/34f41fabd6cb4a7a8b6b758c2ce1965b
Publikováno v:
BMC Biology, Vol 16, Iss 1, Pp 1-16 (2018)
Abstract Background Animal opsins are light-sensitive G-protein-coupled receptors (GPCRs) that enable optogenetic control over the major heterotrimeric G-protein signaling pathways in animal cells. As such, opsins have potential applications in both
Externí odkaz:
https://doaj.org/article/6e01465ae3e94446a265571133022730
Autor:
Phillip Wright, Jessica Rodgers, Jonathan Wynne, Paul N. Bishop, Robert J. Lucas, Nina Milosavljevic
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 23, p 13111 (2021)
The viral gene delivery of optogenetic actuators to the surviving inner retina has been proposed as a strategy for restoring vision in advanced retinal degeneration. We investigated the safety of ectopic expression of human rod opsin (hRHO), and two
Externí odkaz:
https://doaj.org/article/07817c6d095d46388244491b715deb5f
Autor:
Kate A Rawlinson, Francois Lapraz, Edward R Ballister, Mark Terasaki, Jessica Rodgers, Richard J McDowell, Johannes Girstmair, Katharine E Criswell, Miklos Boldogkoi, Fraser Simpson, David Goulding, Claire Cormie, Brian Hall, Robert J Lucas, Maximilian J Telford
Publikováno v:
eLife, Vol 8 (2019)
Animals detect light using opsin photopigments. Xenopsin, a recently classified subtype of opsin, challenges our views on opsin and photoreceptor evolution. Originally thought to belong to the Gαi-coupled ciliary opsins, xenopsins are now understood
Externí odkaz:
https://doaj.org/article/12ff121a75664e8fbf7d31fbc919f6c9
Autor:
Jessica Rodgers, Steven Hughes, Moritz Lindner, Annette E. Allen, Aghileh S. Ebrahimi, Riccardo Storchi, Stuart N. Peirson, Robert J. Lucas, Mark W. Hankins
Publikováno v:
Rodgers, J, Hughes, S, Lindner, M, Allen, A E, Ebrahimi, A S, Storchi, R, Peirson, S N, Lucas, R J & Hankins, M W 2023, ' Functional integrity of visual coding following advanced photoreceptor degeneration ', Current Biology, vol. 33, no. 3, pp. 474-486.e5 . https://doi.org/10.1016/j.cub.2022.12.026
Photoreceptor degeneration sufficient to produce severe visual loss often spares the inner retina. This raises the hope that treatments using optogenetics or electrical stimulation, which generate a replacement light input signal in surviving neurons
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e350cd8173366b2bd6b7e7689c5ceb45
https://doi.org/10.1016/j.cub.2022.12.026
https://doi.org/10.1016/j.cub.2022.12.026
Publikováno v:
McDowell, R J, Rodgers, J, Milosavljevic, N & Lucas, R J 2022, ' Divergent G-protein selectivity across melanopsins from mice and humans ', Journal of Cell Science, vol. 135, no. 6, jcs258474 . https://doi.org/10.1242/jcs.258474
Melanopsin is an opsin photopigment and light-activated G-protein-coupled receptor; it is expressed in photoreceptive retinal ganglion cells (mRGCs) and can be employed as an optogenetic tool. Mammalian melanopsins can signal via Gq/11 and Gi/o/t het
Autor:
Mark W. Hankins, Robert E MacLaren, Jessica Rodgers, Steven Hughes, Navamayooran Thavanesan, Wayne I. L. Davies, Doron G. Hickey
Publikováno v:
The Journal of Experimental Biology
article-version (VoR) Version of Record
article-version (VoR) Version of Record
Human opsin-based photopigments have great potential as light-sensitisers, but their requirement for phototransduction cascade-specific second messenger proteins may restrict their functionality in non-native cell types. In this study, eight chimeric
Autor:
Sarika Paul, Patrycja Orlowska-Feuer, Jessica Rodgers, Robert J. Lucas, Mino D. C. Belle, Edward R. Ballister, Riccardo Storchi, Timothy M. Brown, Nina Milosavljevic, Franck P. Martial, Beatriz Bano-Otalora, Richard J. McDowell, Annette E. Allen, Jonathan Wynne, Rebecca Hughes, Phillip Wright
Publikováno v:
Rodgers, J, Bano-Otalora, B, Belle, M D C, Paul, S, Hughes, R, Wright, P, McDowell, R, Milosavljevic, N, Orlowska-Feuer, P, Martial, F P, Wynne, J, Ballister, E R, Storchi, R, Allen, A E, Brown, T & Lucas, R J 2021, ' Using a bistable animal opsin for switchable and scalable optogenetic inhibition of neurons ', EMBO reports, pp. e51866 . https://doi.org/10.15252/embr.202051866
There is no consensus on the best optogenetic tool for neuronal inhibition. Lamprey parapinopsin (‘Lamplight’) is a Gi/o-coupled bistable animal opsin that can be activated and deactivated by short and long wavelength light, respectively. Since n
Autor:
Anthony A. Vugler, Timothy M. Brown, Jessica Rodgers, Annette E. Allen, Robert J. Lucas, Glen Jeffery, Beatriz Bano-Otalora, Joshua W. Mouland, Ronald H. Douglas
Publikováno v:
The Journal of Experimental Biology
article-version (VoR) Version of Record
article-version (VoR) Version of Record
An animal's temporal niche – the time of day at which it is active – is known to drive a variety of adaptations in the visual system. These include variations in the topography, spectral sensitivity and density of retinal photoreceptors, and chan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc1e61dfe1f14fc4d40a007b48bed278
https://openaccess.city.ac.uk/id/eprint/24077/1/rhabdospec%20sensitivity%20resub%20200409.pdf
https://openaccess.city.ac.uk/id/eprint/24077/1/rhabdospec%20sensitivity%20resub%20200409.pdf
Publikováno v:
Cellular and Molecular Life Sciences
Melanopsin is a blue light-sensitive opsin photopigment involved in a range of non-image forming behaviours, including circadian photoentrainment and the pupil light response. Many naturally occurring genetic variants exist within the human melanopsi