2-Hydroxypropyl-β-cyclodextrin-enhanced pharmacokinetics of cabotegravir from a nanofluidic implant for HIV pre-exposure prophylaxis

Autor: Jesus Paez-Mayorga, Giacomo Bruno, Alessandro Grattoni, Cecilia Martini, Corrine Ying Xuan Chua, Jessica Rhudy, Madhuri Manohar, Nicola Di Trani, Mark A. Marzinke, Fernanda P. Pons-Faudoa, Greta Varchi, Kevin Gwenden, Antons Sizovs

Publikováno v: J Control Release
Journal of controlled release 306 (2019): 89–96. doi:10.1016/j.jconrel.2019.05.037
info:cnr-pdr/source/autori:Pons-Faudoa, Fernanda P.; Sizovs, Antons; Di Trani, Nicola; Paez-Mayorga, Jesus; Bruno, Giacomo; Rhudy, Jessica; Manohar, Madhuri; Gwenden, Kevin; Martini, Cecilia; Chua, Corrine Ying Xuan; Varchi, Greta; Marzinke, Mark A.; Grattoni, Alessandro/titolo:2-Hydroxypropyl-beta-cyclodextrin-enhanced pharmacokinetics of cabotegravir from a nanofluidic implant for HIV pre-exposure prophylaxis/doi:10.1016%2Fj.jconrel.2019.05.037/rivista:Journal of controlled release/anno:2019/pagina_da:89/pagina_a:96/intervallo_pagine:89–96/volume:306

Preexposure prophylaxis (PrEP) with antiretrovirals (ARV) can prevent human immunodeficiency virus (HIV) transmission, but its efficacy is highly dependent on strict patient adherence to daily dosing regimen. Long-acting (LA) ARV formulations or deli

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b213280a09593da1875c18c5e3615a3c
https://doi.org/10.1016/j.jconrel.2019.05.037

Giving new life to old lungs: methods to produce and assess whole human paediatric bioengineered lungs

Autor: Lee C. Woodson, Michael Riddle, Jean A. Niles, Dan Lee, Jason Sakamoto, David Seanor, Vicki J. Schnadig, Joaquin Cortiella, Rahul Pal, Grace Vargas, Lissenya B. Argueta, Saverio La Francesca, Stephanie P. Vega, Gerald A. Campbell, Jessica Rhudy, Joan E. Nichols

Publikováno v: Journal of Tissue Engineering and Regenerative Medicine. 11:2136-2152

We report, for the first time, the development of an organ culture system and protocols to support recellularization of whole acellular (AC) human paediatric lung scaffolds. The protocol for paediatric lung recellularization was developed using human

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::42d28837367409e7f6623a34c565fab1
https://doi.org/10.1002/term.2113

Enhanced In Vivo Vascularization of 3D‐Printed Cell Encapsulation Device Using Platelet‐Rich Plasma and Mesenchymal Stem Cells

Autor: Maria Luisa Lotito, Francesca Taraballi, Bruna Corradetti, Simone Capuani, Corrine Ying Xuan Chua, Marco Farina, Alessandro Grattoni, Joan E. Nichols, Hector F. Salazar, Jean A. Niles, Jessica Rhudy, Kathryn A. Shelton, Jesus Paez-Mayorga, Pramod N. Nehete, Lucas Esnaola

Publikováno v: Advanced Healthcare Materials

The current standard for cell encapsulation platforms is enveloping cells in semipermeable membranes that physically isolate transplanted cells from the host while allowing for oxygen and nutrient diffusion. However, long-term viability and function

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26a2ad8a15e73bc6e4de6b5048abb660
https://doi.org/10.1002/adhm.202000670

Counteracting Muscle Atrophy on Earth and in Space via Nanofluidics Delivery of Formoterol

Autor: Jessica Rhudy, Samuel M. Cadena, Nicola Di Trani, Antonia Susnjar, Danuta Lubicka, Yasaman Shirazi-Fard, Louis S. Stodieck, Corrine Ying Xuan Chua, Alessandro Grattoni, Andrea Ballerini, Grit Laue, Mauro Ferrari, Priya Jain

Publikováno v: Advanced Therapeutics. 3:2000014

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::25841a54241ffffdae512870cbbf992a
https://doi.org/10.1002/adtp.202000014

Nanofluidic drug-eluting seed for sustained intratumoral immunotherapy in triple negative breast cancer

Autor: Cassian Yee, Priya Jain, Giacomo Bruno, Marco Folci, E. Brian Butler, Antonia Susnjar, April L. Gilbert, Corrine Ying Xuan Chua, Carly S. Filgueira, Andrea Ballerini, Jessica Rhudy, Alessandro Grattoni, Shailbala Singh

Publikováno v: Journal of controlled release : official journal of the Controlled Release Society. 285

Conventional systemic immunotherapy administration often results in insufficient anti-tumor immune response and adverse side effects. Delivering immunotherapeutics intratumorally could maximize tumor exposure, elicit efficient anti-tumor immune respo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b0120c2fd8a1473edddfced0baff0ea
https://pubmed.ncbi.nlm.nih.gov/30008369