In vitro activity, safety and in vivo efficacy of the novel bumped kinase inhibitor BKI-1748 in non-pregnant and pregnant mice experimentally infected with Neospora caninum tachyzoites and Toxoplasma gondii oocysts

Autor: Dennis Imhof, Nicoleta Anghel, Pablo Winzer, Vreni Balmer, Jessica Ramseier, Kai Hänggeli, Ryan Choi, Matthew A. Hulverson, Grant R. Whitman, Samuel L.M. Arnold, Kayode K. Ojo, Wesley C. Van Voorhis, J. Stone Doggett, Luis M. Ortega-Mora, Andrew Hemphill

Publikováno v: International Journal for Parasitology: Drugs and Drug Resistance, Vol 16, Iss , Pp 90-101 (2021)

Bumped kinase inhibitors (BKIs) target the apicomplexan calcium-dependent protein kinase 1 (CDPK1). BKI-1748, a 5-aminopyrazole-4-carboxamide compound when added to fibroblast cells concomitantly to the time of infection, inhibited proliferation of a

Externí odkaz: https://doaj.org/article/225361d65821483fab18631218d65033

Assessment of the Activity of Decoquinate and Its Quinoline-O-Carbamate Derivatives against Toxoplasma gondii In Vitro and in Pregnant Mice Infected with T. gondii Oocysts

Autor: Jessica Ramseier, Dennis Imhof, Nicoleta Anghel, Kai Hänggeli, Richard M. Beteck, Vreni Balmer, Luis-Miguel Ortega-Mora, Roberto Sanchez-Sanchez, Ignacio Ferre, Richard K. Haynes, Andrew Hemphill

Publikováno v: Molecules, Vol 26, Iss 21, p 6393 (2021)

The quinolone decoquinate (DCQ) is widely used in veterinary practice for the treatment of bacterial and parasitic infections, most notably, coccidiosis in poultry and in ruminants. We have investigated the effects of treatment of Toxoplasma gondii i

Externí odkaz: https://doaj.org/article/a86f5c8d037a44fca41c7ec06a97d3ad

Endochin-like quinolones (ELQs) and bumped kinase inhibitors (BKIs): Synergistic and additive effects of combined treatments against Neospora caninum infection in vitro and in vivo

Autor: Dennis Imhof, Jessica Ramseier, Wesley C. Van Voorhis, Andrew Hemphill, Samuel L.M. Arnold, Grant R. Whitman, Vreni Balmer, J. Stone Doggett, Matthew A. Hulverson, Ryan Choi, Kayode K. Ojo, Pablo Winzer, Luis Miguel Ortega-Mora, Kai Haenggeli, Nicoleta Anghel

Publikováno v: International Journal for Parasitology: Drugs and Drug Resistance, Vol 17, Iss, Pp 92-106 (2021)
Anghel, Nicoleta; Imhof, Dennis; Winzer, Pablo; Balmer, Vreni; Ramseier, Jessica; Haenggeli, Kai; Choi, Ryan; Hulverson, Matthew A; Whitman, Grant R; Arnold, Samuel L M; Ojo, Kayode K; Van Voorhis, Wesley C; Doggett, J Stone; Ortega-Mora, Luis M; Hemphill, Andrew (2021). Endochin-like quinolones (ELQs) and bumped kinase inhibitors (BKIs): Synergistic and additive effects of combined treatments against Neospora caninum infection in vitro and in vivo. International journal for parasitology. Drugs and drug resistance, 17, pp. 92-106. Elsevier 10.1016/j.ijpddr.2021.08.007
International Journal for Parasitology: Drugs and Drug Resistance

The apicomplexan parasite Neospora caninum is an important causative agent of congenital neosporosis, resulting in abortion, birth of weak offspring and neuromuscular disorders in cattle, sheep, and many other species. Among several compound classes

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f47feace5d35bf82430013b60b579c9e
http://www.sciencedirect.com/science/article/pii/S2211320721000439

Conjugates Containing Two and Three Trithiolato-Bridged Dinuclear Ruthenium(II)-Arene Units as In Vitro Antiparasitic and Anticancer Agents

Autor: Andrew Hemphill, Yosra Amdouni, Jessica Ramseier, Julien Furrer, Martin Hungerbühler, Nicoleta Anghel, Timo Felder, Valentin Studer, Oksana Desiatkina, Johannes T. Heverhagen, Ghalia Boubaker, Nico Ruprecht, Emilia Păunescu, Christoph Kempf

Publikováno v: Pharmaceuticals
Volume 13
Issue 12
Pharmaceuticals, Vol 13, Iss 471, p 471 (2020)
Studer, Valentin; Anghel, Nicoleta; Desiatkina, Oksana; Felder, Timo; Boubaker, Ghalia; Amdouni, Yosra; Ramseier, Jessica; Hungerbühler, Martin; Kempf, Christoph; Heverhagen, Johannes Thomas; Hemphill, Andrew; Ruprecht, Nico; Furrer, Julien; Păunescu, Emilia (2020). Conjugates Containing Two and Three Trithiolato-Bridged Dinuclear Ruthenium(II)-Arene Units as In Vitro Antiparasitic and Anticancer Agents. Pharmaceuticals, 13(12), p. 471. MDPI 10.3390/ph13120471

The synthesis, characterization, and in vitro antiparasitic and anticancer activity evaluation of new conjugates containing two and three dinuclear trithiolato-bridged ruthenium(II)-arene units are presented. Antiparasitic activity was evaluated usin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::efddfe54d644bdc319cbbade8aa82e35