Výsledky vyhledávání - "Jessica Raiz"

Akademický článek

Topical Isotretinoin (TMB-001) Treatment for 12 Weeks Did Not Result in Clinically Relevant Laboratory Abnormalities in Participants with Congenital Ichthyosis in the Phase 2b CONTROL Study

Autor: Kalyani Marathe, Joyce M. C. Teng, Scott Guenthner, Christopher G. Bunick, Steven Kempers, Kimmie Eads, Leslie Castelo-Soccio, Alan M. Mendelsohn, Jessica Raiz, Dédée F. Murrell

Publikováno v: Dermatology and Therapy, Vol 13, Iss 6, Pp 1255-1264 (2023)

Abstract Introduction Treatment with oral retinoids can be effective in patients with congenital ichthyosis (CI) but may be associated with clinically significant laboratory changes. In this Phase 2b CONTROL study analysis, we characterize the effect

Externí odkaz: https://doaj.org/article/0589bfedc89443abbc72105e37c33aed

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Characteristics and outcomes for participants with congenital ichthyosis who responded to treatment with the topical isotretinoin formulation TMB-001: results from the Phase IIb CONTROL study

Autor: Christopher G. Bunick, Joyce M.C. Teng, Scott Guenthner, Kalyani Marathe, Steven Kempers, Kimmie Eads, Leslie Castelo-Soccio, Alan M. Mendelsohn, Jessica Raiz, Dédée F. Murrell

Publikováno v: Clinical and Experimental Dermatology.

Background Emollients and keratolytics are frequently used to manage symptoms of congenital ichthyosis (CI). Systemic retinoid treatment is complicated by teratogenicity and dose-limiting adverse effects. Objectives This analysis from the randomized

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::929d6ec16aaafebddd30b312edc4f2c3
https://doi.org/10.1093/ced/llad105

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Phase IIb randomized CONTROL study demonstrates a novel topical isotretinoin formulation, TMB-001, is safe and effective in participants with either recessive X-linked or autosomal recessive lamellar congenital ichthyosis

Autor: Dedee F Murrell, Joyce M C Teng, Scott Guenthner, Kalyani Marathe, Steven Kempers, Kimmie Eads, Leslie Castelo-Soccio, Alan M Mendelsohn, Jessica Raiz, Christopher G Bunick

Publikováno v: Clinical and Experimental Dermatology.

BackgroundIn two severe congenital ichthyosis subtypes, autosomal recessive lamellar ichthyosis (ARCI-LI) and X-linked recessive ichthyosis (XLRI), cutaneous manifestations include widespread scaling. Approved topical treatment options are limited to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::005dcf3a2e6299e088207f1355d623f9
https://doi.org/10.1093/ced/llad033

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The CONTROL study: A randomized, double-blind vehicle-controlled phase 2b study of novel topical isotretinoin formulation demonstrates improvement in recessive X-linked and autosomal recessive lamellar congenital ichthyosis

Autor: Joyce M.C. Teng, Christopher G. Bunick, Scott Guenthner, Dedee F. Murrell, Kalyani Marathe, Steven Kempers, Kimmie Eads, Alan M. Mendelsohn, Jessica Raiz, Amir Tavakkol, Leslie Castelo-Soccio

Publikováno v: Journal of the American Academy of Dermatology. 87(6)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::552b8f68ef9a037b24a70ff4b5f5d1e5
https://pubmed.ncbi.nlm.nih.gov/35872261

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