A distinct epigenetic profile distinguishes stenotic from non-inflamed fibroblasts in the ileal mucosa of Crohn's disease patients.

Autor: Andrew Y F Li Yim, Jessica R de Bruyn, Nicolette W Duijvis, Catriona Sharp, Enrico Ferrero, Wouter J de Jonge, Manon E Wildenberg, Marcel M A M Mannens, Christianne J Buskens, Geert R D'Haens, Peter Henneman, Anje A Te Velde

Publikováno v: PLoS ONE, Vol 13, Iss 12, p e0209656 (2018)

BackgroundThe chronic remitting and relapsing intestinal inflammation characteristic of Crohn's disease frequently leads to fibrosis and subsequent stenosis of the inflamed region. Approximately a third of all Crohn's disease patients require resecti

Externí odkaz: https://doaj.org/article/4d247c38076e4a7984fa3ae11f10c912

Peripheral Blood DNA Methylation Profiles Do Not Predict Endoscopic Post-Operative Recurrence in Crohn's Disease Patients

Autor: Vincent W. Joustra, Andrew Y. F. Li Yim, Jessica R. de Bruyn, Marjolijn Duijvestein, Ishtu L. Hageman, Wouter J. de Jonge, Peter Henneman, Manon Wildenberg, Geert D’Haens

Publikováno v: International journal of molecular sciences, 23(18):10467. Multidisciplinary Digital Publishing Institute (MDPI)
International Journal of Molecular Sciences; Volume 23; Issue 18; Pages: 10467
International Journal of Molecular Sciences, 23
International Journal of Molecular Sciences, 23, 18

Prediction of endoscopic post-operative recurrence (POR) in Crohn’s disease (CD) patients following ileocolonic resection (ICR) using clinical risk factors alone has thus far been inadequate. While peripheral blood leukocyte (PBL) DNA methylation h

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96e83d5d0dfda187e2be107573e1db27
https://pure.amc.nl/en/publications/peripheral-blood-dna-methylation-profiles-do-not-predict-endoscopic-postoperative-recurrence-in-crohns-disease-patients(d256de81-d76a-4a49-b686-612145179a17).html

High-Dose Vitamin D Does Not Prevent Postoperative Recurrence of Crohn's Disease in a Randomized Placebo-Controlled Trial

Autor: Jessica R. de Bruyn, Peter Bossuyt, Marc Ferrante, Rachel L. West, Gerard Dijkstra, Ben J. Witteman, Manon Wildenberg, Frank Hoentjen, Denis Franchimont, Esmé Clasquin, Jarmila D. van der Bilt, Tim Tollens, Willem A. Bemelman, Andre D’Hoore, Marjolijn Duijvestein, Geert R. D’Haens, W. Bemelman, C. Buskens, E. Clasquin, J. De Bruyn, G. D’Haens, M. Duijvestein, J. Van der Bilt, B. Ferreira, S. Mulder, R. West, G. Dijkstra, A. Engelsman, J. Lange, L. Homans, B. Witteman, A. Eroglu-Berger, M. Russel, J. Jansen, T. Schakel–van den Berge, S. Cuppen, F. Hoentjen, A. Van Esch, D.J. De Jong, N. Mahmmod, W. Ten Hove.P. De Lange, R. Mallant, P. Houben, M. Ferrante, S. Vermeire, A. Outtier, T. Hermans, J. Lefrère, A. D’Hoore, K. Asnong, P. Bossuyt, I. Van de Schoot, B. Claerbout, G. Lambrecht, L. Boutaffala, C. Guebelle, E. Louis, D. Franchimont, V. Wambacq, A. Colard, A. Deflandre

Publikováno v: Clinical Gastroenterology and Hepatology, 19, 1573-1582.e5
Clinical Gastroenterology and Hepatology, 19, 8, pp. 1573-1582.e5
Clinical Gastroenterology and Hepatology, 19(8), 1573-1582.e5. ELSEVIER SCIENCE INC
Clinical gastroenterology and hepatology, 19(8), 1573-1582.e5. W.B. Saunders Ltd

BACKGROUND & AIMS: Vitamin D deficiency is common in Crohn's disease (CD). High-dose vitamin D had anti-inflammatory effects in preclinical studies and trials of patients with CD. We performed a randomized trial to determine whether high-dose vitamin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::745c4b94532c3a697791ed92464ebe3c
https://hdl.handle.net/2066/237041

Intestinal fibrosis is associated with lack of response to Infliximab therapy in Crohn's disease

Autor: Sybren L. Meijer, Willem A. Bemelman, Cyriel Y. Ponsioen, Gijs R. van den Brink, Manon E. Wildenberg, Geert R. D'Haens, Christianne J. Buskens, M Becker, Jessica R. de Bruyn, Mark Löwenberg, Jessica Steenkamer

Publikováno v: PLoS ONE
PLoS ONE, 13(1). Public Library of Science
PLoS ONE, Vol 13, Iss 1, p e0190999 (2018)

Introduction Overt fibrostenotic disease is a relative contraindication for anti-TNF therapy in Crohn’s disease. We hypothesized that subclinical fibrosis may also contribute to an incomplete response to anti-TNF therapy before the onset of symptom

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68c9b62aaa260f6f22c36dabba4e98b5
https://doi.org/10.1371/journal.pone.0190999

Development of Fibrosis in Acute and Longstanding Ulcerative Colitis

Autor: Gijs R. van den Brink, Sybren L. Meijer, Jessica R. de Bruyn, Willem A. Bemelman, Geert R. D'Haens, Manon E. Wildenberg

Publikováno v: Journal of Crohn s & colitis, 9(11), 966-972. Elsevier

Background: Intestinal fibrosis is a process driven by chronic inflammation leading to increased presence of myofibroblasts and collagen deposition. Although strictures are rarely seen in ulcerative colitis [UC], longstanding disease is believed to c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c7f256a6495a386fdb191480a7de71d2
https://doi.org/10.1093/ecco-jcc/jjv133