Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Jessica R. Weaver"'
Autor:
Justin J. Odanga, Sharon M. Anderson, Erick K. Breathwaite, Sharon C. Presnell, Edward L. LeCluyse, Jingsong Chen, Jessica R. Weaver
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-13 (2024)
Abstract Liver diseases, including NAFLD, are a growing worldwide health concern. Currently, there is a lack of suitable in vitro models that sustain basic primary human hepatocyte (PHH) morphology and functionality while supporting presentation of d
Externí odkaz:
https://doaj.org/article/3a0a4cf5b93f4ff7800f377f929071e4
Autor:
Jessica R. Weaver, PhD, Carolina M. Casellini, MD, Henri K. Parson, PhD, Aaron I. Vinik, MD, PhD, FCP, MACP, FACE
Publikováno v:
AACE Clinical Case Reports, Vol 4, Iss 3, Pp 263-266 (2018)
ABSTRACT: Objective: Newly diagnosed type 2 diabetes mellitus (T2DM) increases the risk of pancreatic cancer by an unknown mechanism. We report a patient diagnosed with T2DM
Externí odkaz:
https://doaj.org/article/078f6146c50741539f022bd34a07826c
Autor:
Jessica R. Weaver, Justin J. Odanga, Kristina K. Wolf, Stephanie Piekos, Mercedes Biven, Mitchell Taub, Jessica LaRocca, Cody Thomas, Alexander Byer-Alcorace, Jingsong Chen, Jung Bok Lee, Edward L. LeCluyse
Publikováno v:
Toxicology in vitro : an international journal published in association with BIBRA. 86
There remains a significant need for a convenient, phenotypically stable long-term culture platform for primary human hepatocytes (PHHs) for use in pharmacological and toxicological applications. Conventional in vitro models are often inconvenient, b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0afa037f981b014ced9922835e80f3e7
https://pubmed.ncbi.nlm.nih.gov/36288780
https://pubmed.ncbi.nlm.nih.gov/36288780
Autor:
Jung Bok Lee, Justin J. Odanga, Erick K Breathwaite, Michelle L Treadwell, Jessica R Weaver, Angela C. Murchison
Publikováno v:
International Journal of Stem Cells
Human pluripotent stem cells (hPSCs) hold great promise for future applications in drug discovery and cell therapies. hPSC culture protocols require specific substrates and medium supplements to support cell expansion and lineage specific differentia
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::690c3338f8e9bdec51be76c8d9763e2d
https://doi.org/10.15283/ijsc20074
https://doi.org/10.15283/ijsc20074
Publikováno v:
PLoS ONE, Vol 10, Iss 11, p e0142735 (2015)
Pathology driving β-cell loss in diabetes is poorly defined. Chronic subclinical inflammation is associated with β-cell dysfunction. Acute in vitro exposure of islets and β-cells to an inflammatory cytokine cocktail (IL-1β/TNF-α/IFN-γ) results
Externí odkaz:
https://doaj.org/article/3cbd3fe880c64c7a8d03569c7ac6e49e
Autor:
Carolina Casellini, Jessica R. Weaver, Henri K. Parson, Aaron I. Vinik, Jung Hwa Jung, Danuta Sosnowska
Publikováno v:
Reports, Vol 3, Iss 30, p 30 (2020)
Reports
Volume 3
Issue 4
Reports
Volume 3
Issue 4
Background: Early diagnosis in pancreatic cancer is key for improving prognosis. Hypoxia plays a critical role in tumor progression. Thus, an evaluation of associations between pancreatic tumor progression and markers of hypoxia is needed. Methods: W
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7fae06afbc136fdf597fbd8f00acaff9
https://www.mdpi.com/2571-841X/3/4/30
https://www.mdpi.com/2571-841X/3/4/30
Autor:
Danette P Fuentes, Erick K Breathwaite, Gary Walters, Jung Bok Lee, Justin J. Odanga, Angela C Murchinson, Michelle L Treadwell, Jessica R Weaver
Publikováno v:
Diabetes/metabolism research and reviewsREFERENCES. 37(6)
Aims Type 2 diabetes (T2D) is a global health problem that will be diagnosed in almost 300 million people by 2025 according to the World Health Organization. Before being diagnosed with T2D, individuals may have glucose levels above normal but below
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b53acb3777e1ac116beda1e9df2a24b
https://pubmed.ncbi.nlm.nih.gov/33463010
https://pubmed.ncbi.nlm.nih.gov/33463010
Autor:
Raghavendra G. Mirmira, Kaiwen Ma, So Hyun Park, Jessica R. Weaver, Tatvam Barot, Diane K. Luci, David A. Taylor-Fishwick, Yumi Imai, David J. Maloney, Jerry L. Nadler, Laura Jackson, An Xiao, Lindsey Glenn
Publikováno v:
The Journal of Clinical Endocrinology & Metabolism. 102:2789-2797
Context The 12-lipoxygenase (12-LO) pathway produces proinflammatory metabolites, and its activation is implicated in islet inflammation associated with type 1 and type 2 diabetes (T2D). Objectives We aimed to test the efficacy of ML355, a highly sel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de4cdda3d4ebc0ea88124b7784305d4e
https://doi.org/10.1210/jc.2017-00267
https://doi.org/10.1210/jc.2017-00267
Publikováno v:
Biochemical and Biophysical Research Communications. 485:290-294
Redox stress related loss of beta cell function is a feature of diabetes. Exposure of beta cells and islets to inflammatory mediators elevates reactive oxygen species (ROS) and beta cell dysfunction. Direct molecular manipulation of NADPH oxidase-1 (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37d66a6685c5718ee04029663bc9d877
https://doi.org/10.1016/j.bbrc.2017.02.089
https://doi.org/10.1016/j.bbrc.2017.02.089
Autor:
Nigel A. Calcutt, Michael D. Bailey, Katie E. Frizzi, Jessica R. Weaver, Paul Fernyhough, Joshua Edwards, Lindsey B. Cundra, Carolina Casellini, Henri K. Parson, Aaron I. Vinik
Publikováno v:
Diabetes. 67
Degeneration of nerve fibers due to diabetic peripheral neuropathy (DPN) has been linked to mitochondrial dysfunction. Manipulation of mitochondrial dysfunction through antagonism of muscarinic receptors (MR) promotes neurite outgrowth in adult senso
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ccbddc7867dbed2b397814b8aabcecd7
https://doi.org/10.2337/db18-58-or
https://doi.org/10.2337/db18-58-or