Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Jessica R. Loughland"'
Autor:
Nicholas L. Dooley, Tinashe G. Chabikwa, Zuleima Pava, Jessica R. Loughland, Julianne Hamelink, Kiana Berry, Dean Andrew, Megan S. F. Soon, Arya SheelaNair, Kim A. Piera, Timothy William, Bridget E. Barber, Matthew J. Grigg, Christian R. Engwerda, J. Alejandro Lopez, Nicholas M. Anstey, Michelle J. Boyle
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-22 (2023)
Abstract Plasmodium falciparum malaria drives immunoregulatory responses across multiple cell subsets, which protects from immunopathogenesis, but also hampers the development of effective anti-parasitic immunity. Understanding malaria induced tolero
Externí odkaz:
https://doaj.org/article/d4f0ae647bca412fa846c8d4ab492791
Autor:
Yulin Wang, Fabian De Labastida Rivera, Chelsea L. Edwards, Teija C.M. Frame, Jessica A. Engel, Luzia Bukali, Jinrui Na, Susanna S. Ng, Dillon Corvino, Marcela Montes de Oca, Patrick T. Bunn, Megan S.F. Soon, Dean Andrew, Jessica R. Loughland, Jia Zhang, Fiona H. Amante, Bridget E. Barber, James S. McCarthy, J. Alejandro Lopez, Michelle J. Boyle, Christian R. Engwerda
Publikováno v:
The Journal of Clinical Investigation, Vol 133, Iss 19 (2023)
The development of highly effective malaria vaccines and improvement of drug-treatment protocols to boost antiparasitic immunity are critical for malaria elimination. However, the rapid establishment of parasite-specific immune regulatory networks fo
Externí odkaz:
https://doaj.org/article/3c2a3ba4c5594fffbb78ac8fa7298d0d
Autor:
Jo-Anne Chan, Jessica R. Loughland, Lauren de la Parte, Satomi Okano, Isaac Ssewanyana, Mayimuna Nalubega, Felistas Nankya, Kenneth Musinguzi, John Rek, Emmanuel Arinaitwe, Peta Tipping, Peter Bourke, Dean Andrew, Nicholas Dooley, Arya SheelaNair, Bruce D. Wines, P. Mark Hogarth, James G. Beeson, Bryan Greenhouse, Grant Dorsey, Moses Kamya, Gunter Hartel, Gabriela Minigo, Margaret Feeney, Prasanna Jagannathan, Michelle J. Boyle
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)
Despite being key drivers of protective antibodies against malaria, little is known regarding the host and parasite factors that influence CD4 T-follicular helper cell and antibody development. Authors utilise samples from a study of children living
Externí odkaz:
https://doaj.org/article/cbf04ed2b51b46b3bbb1c106a6ca7595
Autor:
Chelsea L. Edwards, Susanna S. Ng, Fabian de Labastida Rivera, Dillon Corvino, Jessica A. Engel, Marcela Montes de Oca, Luzia Bukali, Teija C.M. Frame, Patrick T. Bunn, Shashi Bhushan Chauhan, Siddharth Sankar Singh, Yulin Wang, Jinrui Na, Fiona H. Amante, Jessica R. Loughland, Megan S.F. Soon, Nicola Waddell, Pamela Mukhopadhay, Lambros T. Koufariotis, Rebecca L. Johnston, Jason S. Lee, Rachel Kuns, Ping Zhang, Michelle J. Boyle, Geoffrey R. Hill, James S. McCarthy, Rajiv Kumar, Christian R. Engwerda
Publikováno v:
The Journal of Clinical Investigation, Vol 133, Iss 4 (2023)
Externí odkaz:
https://doaj.org/article/1c7a7aac042d489a8d9ce7e4e35f9dc0
Autor:
Jessica R. Loughland, Tonia Woodberry, Damian Oyong, Kim A. Piera, Fiona H. Amante, Bridget E. Barber, Matthew J. Grigg, Timothy William, Christian R. Engwerda, Nicholas M. Anstey, James S. McCarthy, Michelle J. Boyle, Gabriela Minigo
Publikováno v:
Malaria Journal, Vol 20, Iss 1, Pp 1-8 (2021)
Abstract Background Plasmodium falciparum malaria increases plasma levels of the cytokine Fms-like tyrosine kinase 3 ligand (Flt3L), a haematopoietic factor associated with dendritic cell (DC) expansion. It is unknown if the zoonotic parasite Plasmod
Externí odkaz:
https://doaj.org/article/ceb09602cd7c423e8c2a5de4a5614c22
Autor:
Damian A. Oyong, Jessica R. Loughland, Arya SheelaNair, Dean Andrew, Fabian D. L. Rivera, Kim A. Piera, Timothy William, Matthew J. Grigg, Bridget E. Barber, Ashraful Haque, Christian R. Engwerda, James S. McCarthy, Nicholas M. Anstey, Michelle J. Boyle
Publikováno v:
Malaria Journal, Vol 18, Iss 1, Pp 1-11 (2019)
Abstract Background Anaemia is a major consequence of malaria, caused by the removal of both infected and uninfected red blood cells (RBCs) from the circulation. Complement activation and reduced expression of complement regulatory proteins (CRPs) on
Externí odkaz:
https://doaj.org/article/a70d3c0bb8f34de8881f93313f1c172d
Autor:
Jessica R. Loughland, Gabriela Minigo, Derek S. Sarovich, Matt Field, Peta E. Tipping, Marcela Montes de Oca, Kim A. Piera, Fiona H. Amante, Bridget E. Barber, Matthew J. Grigg, Timothy William, Michael F. Good, Denise L. Doolan, Christian R. Engwerda, Nicholas M. Anstey, James S. McCarthy, Tonia Woodberry
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-11 (2017)
Abstract Plasmacytoid dendritic cells (pDC) are activators of innate and adaptive immune responses that express HLA-DR, toll-like receptor (TLR) 7, TLR9 and produce type I interferons. The role of human pDC in malaria remains poorly characterised. pD
Externí odkaz:
https://doaj.org/article/7fc57d1115ad4d4da48e9b4697978c9e
Autor:
Marcela Montes de Oca, Rajiv Kumar, Fabian de Labastida Rivera, Fiona H. Amante, Meru Sheel, Rebecca J. Faleiro, Patrick T. Bunn, Shannon E. Best, Lynette Beattie, Susanna S. Ng, Chelsea L. Edwards, Glen M. Boyle, Ric N. Price, Nicholas M. Anstey, Jessica R. Loughland, Julie Burel, Denise L. Doolan, Ashraful Haque, James S. McCarthy, Christian R. Engwerda
Publikováno v:
Cell Reports, Vol 17, Iss 2, Pp 399-412 (2016)
The development of immunoregulatory networks is important to prevent disease. However, these same networks allow pathogens to persist and reduce vaccine efficacy. Here, we identify type I interferons (IFNs) as important regulators in developing anti-
Externí odkaz:
https://doaj.org/article/9b05fd1ed67d459e9852bf440f0c5250
Autor:
Nicholas L. Dooley, Tinashe G. Chabikwa, Zuleima Pava, Jessica R. Loughland, Julianne Hamelink, Kiana Berry, Dean Andrew, Megan S.F. Soon, Arya SheelaNair, Kim A. Piera, Timothy William, Bridget E. Barber, Matthew J. Grigg, Christian R. Engwerda, J. Alejandro López, Nicholas M. Anstey, Michelle J. Boyle
Plasmodium falciparummalaria results in immunoregulatory responses across multiple cell subsets, which protects the individual from inflammatory mediated immunopathogenesis. However, these anti-inflammatory responses also hamper the development of ef
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3babe7dc4e5e18c8162f4d85c24c1307
https://doi.org/10.1101/2022.11.16.516822
https://doi.org/10.1101/2022.11.16.516822
Autor:
Yulin Wang, Fabian De Labastida Rivera, Chelsea L. Edwards, Teija C. M. Frame, Jessica A. Engel, Luzia Bukali, Jinrui Na, Susanna S. Ng, Dillon Corvino, Marcela Montes de Oca, Patrick T. Bunn, Megan S. F. Soon, Dean Andrew, Jessica R. Loughland, Fiona H. Amante, Bridget E. Barber, James S. McCarthy, J. Alejandro Lopez, Michelle J. Boyle, Christian R. Engwerda
SummaryThe development of highly effective malaria vaccines and improving drug treatment protocols to boost anti-parasitic immunity is critical for malaria elimination. However, these efforts are hampered by parasite-specific immunoregulatory network
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::75654ac34d728db49ecb5ed4a06ef70b
https://doi.org/10.1101/2022.09.04.506109
https://doi.org/10.1101/2022.09.04.506109