Zobrazeno 1 - 10
of 40
pro vyhledávání: '"Jessica R. Blount"'
Autor:
Mackenzie L. Connell, Chia-Chen Wu, Jessica R. Blount, Alex Haimbaugh, Emily K. Kintzele, Dayita Banerjee, Bridget B. Baker, Tracie R. Baker
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 22, p 16212 (2023)
Urban environments are afflicted by mixtures of anthropogenic volatile organic compounds (VOCs). VOC sources that drive human exposure include vehicle exhaust, industrial emissions, and oil spillage. The highly volatile VOC benzene has been linked to
Externí odkaz:
https://doaj.org/article/0f7c999f90da4222afae0ce912ecbd2c
Autor:
Jessica R. Blount, Jeremiah N. Shields, Chia-Chen Wu, Camille Akemann, Bridget B. Baker, Zoha Siddiqua, Danielle N. Meyer, Nemer Hijazi, Zane Tolbert, David K. Pitts, Tracie R. Baker
Publikováno v:
Environmental Advances, Vol 7, Iss , Pp 100151- (2022)
This study investigates the pesticides atrazine, chlorpyrifos, and dieldrin for endocrine disrupting, phenotypic, and neurobehavioral effects. Zebrafish embryos were exposed to various environmentally relevant concentrations of pesticides during two
Externí odkaz:
https://doaj.org/article/23186f9534794af6b20f930d45b4e591
Autor:
Sean L. Johnson, Kozeta Libohova, Jessica R. Blount, Alyson L. Sujkowski, Matthew V. Prifti, Wei-Ling Tsou, Sokol V. Todi
Publikováno v:
Neurobiology of Disease, Vol 160, Iss , Pp 105516- (2021)
Of the family of polyglutamine (polyQ) neurodegenerative diseases, Spinocerebellar Ataxia Type 3 (SCA3) is the most common. Like other polyQ diseases, SCA3 stems from abnormal expansions in the CAG triplet repeat of its disease gene resulting in elon
Externí odkaz:
https://doaj.org/article/4145f2bc2303482496fb5dcc3f8aeb43
Autor:
Chia-Chen Wu, Jessica R. Blount, Alex Haimbaugh, Samantha Heldman, Jeremiah N. Shields, Tracie R. Baker
Publikováno v:
Toxics, Vol 10, Iss 7, p 351 (2022)
Urban environments are plagued by complex mixtures of anthropogenic volatile organic compounds (VOCs), such as mixtures of benzene, toluene, ethylene, and xylene (BTEX). Sources of BTEX that drive human exposure include vehicle exhaust, industrial em
Externí odkaz:
https://doaj.org/article/1e09436583a2496ca38d7853af0ccfaa
Autor:
Sean L. Johnson, Matthew V. Prifti, Alyson Sujkowski, Kozeta Libohova, Jessica R. Blount, Luke Hong, Wei-Ling Tsou, Sokol V. Todi
Publikováno v:
Cells, Vol 11, Iss 7, p 1223 (2022)
RNA toxicity contributes to diseases caused by anomalous nucleotide repeat expansions. Recent work demonstrated RNA-based toxicity from repeat-associated, non-AUG-initiated translation (RAN translation). RAN translation occurs around long nucleotide
Externí odkaz:
https://doaj.org/article/e51ea5429bd84786acb22c4db37d5b71
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 8 (2020)
The small modifier protein, ubiquitin, holds a special place in eukaryotic biology because of its myriad post-translational effects that control normal cellular processes and are implicated in various diseases. By being covalently conjugated onto oth
Externí odkaz:
https://doaj.org/article/a5b3681a2a0041e3b73d5b90ef203b18
Autor:
Sean L. Johnson, Jessica R. Blount, Kozeta Libohova, Bedri Ranxhi, Henry L. Paulson, Wei-Ling Tsou, Sokol V. Todi
Publikováno v:
Neurobiology of Disease, Vol 132, Iss , Pp - (2019)
The most commonly inherited dominant ataxia, Spinocerebellar Ataxia Type 3 (SCA3), is caused by a CAG repeat expansion that encodes an abnormally long polyglutamine (polyQ) repeat in the disease protein ataxin-3, a deubiquitinase. Two major full-leng
Externí odkaz:
https://doaj.org/article/ebbebc66357149858167c2c8cb49cc7d
Autor:
Jessica R. Blount, Danielle N. Meyer, Camille Akemann, Sean L. Johnson, Katherine Gurdziel, Tracie R. Baker, Sokol V. Todi
Publikováno v:
Biology Open, Vol 8, Iss 5 (2019)
The small protein modifier ubiquitin regulates various aspects of cellular biology through its chemical conjugation onto proteins. Ubiquitination of proteins presents itself in numerous iterations, from a single mono-ubiquitination event to chains of
Externí odkaz:
https://doaj.org/article/b4ae9856d0d64f089f1c612b5fd4d9e2
Publikováno v:
Cells, Vol 9, Iss 6, p 1519 (2020)
Ubiquitination is a post-translational modification that regulates cellular processes by altering the interactions of proteins to which ubiquitin, a small protein adduct, is conjugated. Ubiquitination yields various products, including mono- and poly
Externí odkaz:
https://doaj.org/article/cb874a69dcc8446a9a2d2bcb05a2556c
Autor:
Wei-Ling Tsou, Michelle Ouyang, Ryan R. Hosking, Joanna R. Sutton, Jessica R. Blount, Aaron A. Burr, Sokol V. Todi
Publikováno v:
Neurobiology of Disease, Vol 82, Iss , Pp 12-21 (2015)
Ataxin-3 is a deubiquitinase and polyglutamine (polyQ) disease protein with a protective role in Drosophila melanogaster models of neurodegeneration. In the fruit fly, wild-type ataxin-3 suppresses toxicity from several polyQ disease proteins, includ
Externí odkaz:
https://doaj.org/article/f04b9134a46347b3a6fc91a36e74868b