Skp, Cullin, F-box (SCF)-Met30 and SCF-Cdc4-Mediated Proteolysis of CENP-A Prevents Mislocalization of CENP-A for Chromosomal Stability in Budding Yeast.

Autor: Wei-Chun Au, Tianyi Zhang, Prashant K Mishra, Jessica R Eisenstatt, Robert L Walker, Josefina Ocampo, Anthony Dawson, Jack Warren, Michael Costanzo, Anastasia Baryshnikova, Karin Flick, David J Clark, Paul S Meltzer, Richard E Baker, Chad Myers, Charles Boone, Peter Kaiser, Munira A Basrai

Publikováno v: PLoS Genetics, Vol 16, Iss 2, p e1008597 (2020)

Restricting the localization of the histone H3 variant CENP-A (Cse4 in yeast, CID in flies) to centromeres is essential for faithful chromosome segregation. Mislocalization of CENP-A leads to chromosomal instability (CIN) in yeast, fly and human cell

Externí odkaz: https://doaj.org/article/4a4e4d4931964e2b9c6fa1e904c0dd0e

The inhibition of checkpoint activation by telomeres does not involve exclusion of dimethylation of histone H4 lysine 20 (H4K20me2) [version 2; referees: 2 approved, 1 not approved]

Autor: Julien Audry, Jinyu Wang, Jessica R. Eisenstatt, Kathleen L. Berkner, Kurt W. Runge

Publikováno v: F1000Research, Vol 7 (2018)

DNA double-strand breaks (DSBs) activate the DNA damage checkpoint machinery to pause or halt the cell cycle. Telomeres, the specific DNA-protein complexes at linear eukaryotic chromosome ends, are capped DSBs that do not activate DNA damage checkpoi

Externí odkaz: https://doaj.org/article/0417e68b9cb641f0aeec88c8ad315a2a

Cdc7-mediated phosphorylation of Cse4 regulates high-fidelity chromosome segregation in budding yeast

Autor: Kerry Bloom, Prashant K. Mishra, Robert A. Sclafani, Peter H. Thorpe, Henry Wood, Lars Boeckmann, Jessica R. Eisenstatt, Munira A. Basrai, John Stanton, Michael Weinreich, Wei-Chun Au

Publikováno v: Molecular Biology of the Cell

Faithful chromosome segregation maintains chromosomal stability as errors in this process contribute to chromosomal instability (CIN), which has been observed in many diseases including cancer. Epigenetic regulation of kinetochore proteins such as Cs

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0629927706f41a331ebc54eaf0f14dd7
http://europepmc.org/articles/PMC8693968

Dbf4-Dependent Kinase (DDK)-Mediated Proteolysis of CENP-A Prevents Mislocalization of CENP-A in

Autor: Jessica R, Eisenstatt, Lars, Boeckmann, Wei-Chun, Au, Valerie, Garcia, Levi, Bursch, Josefina, Ocampo, Michael, Costanzo, Michael, Weinreich, Robert A, Sclafani, Anastasia, Baryshnikova, Chad L, Myers, Charles, Boone, David J, Clark, Richard, Baker, Munira A, Basrai

Publikováno v: G3: Genes|Genomes|Genetics

The evolutionarily conserved centromeric histone H3 variant (Cse4 in budding yeast, CENP-A in humans) is essential for faithful chromosome segregation. Mislocalization of CENP-A to non-centromeric chromatin contributes to chromosomal instability (CIN

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::e64f89b9e28cdd05501ae6f57b2d5e48
https://pubmed.ncbi.nlm.nih.gov/32295767

Skp, Cullin, F-box (SCF)-Met30 and SCF-Cdc4-Mediated Proteolysis of CENP-A Prevents Mislocalization of CENP-A for Chromosomal Stability in Budding Yeast

Autor: Chad L. Myers, Paul S. Meltzer, Munira A. Basrai, Michael Costanzo, Jessica R. Eisenstatt, Anastasia Baryshnikova, Charles Boone, Jack Warren, Tianyi Zhang, Richard Baker, Wei Chun Au, David Clark, Robert L. Walker, Josefina Ocampo, Peter K. Kaiser, Karin Flick, Anthony R. Dawson, Prashant K. Mishra

Publikováno v: PLoS Genetics, Vol 16, Iss 2, p e1008597 (2020)
PLoS genetics, vol 16, iss 2
PLoS Genetics
CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
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Restricting the localization of the histone H3 variant CENP-A (Cse4 in yeast, CID in flies) to centromeres is essential for faithful chromosome segregation. Mislocalization of CENP-A leads to chromosomal instability (CIN) in yeast, fly and human cell

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::227a03b20d02fb24ea8e224fc4102e64
https://doi.org/10.1371/journal.pgen.1008597