CARMN Loss Regulates Smooth Muscle Cells and Accelerates Atherosclerosis in Mice

Autor: Marion J.J. Gijbels, Mukesh Kumar Lalwani, Matthew R. Bennett, Jessica P. Scanlon, Dónal O'Carroll, Kim van Kuijk, Francesca Vacante, David E. Newby, Amanda C Doran, Amira D. Mahmoud, Andrew H. Baker, Thomas C Williams, Judith C. Sluimer, Patrick W. F. Hadoke, Mauro Giacca, Michael B. Clark, Laura Denby, Rusty L. Montgomery, Jenny de Bruijn, Eileen Miller, Julie Rodor, Azzurra L De Pace

Publikováno v: Circulation research, 128(9), 1258-1275. Lippincott Williams and Wilkins
Circulation Research, 128(9), 1258-1275. LIPPINCOTT WILLIAMS & WILKINS
Circ Res
Vacante, F, Rodor, J, Lalwani, M, Mahmoud, A, Bennett, M, De Pace, A, Miller, E, van Kuijk, K, de Bruijn, J, Gijbels, M, Williams, T C, Clark, M, Scanlon, J, Doran, A, Montgomery, R, Newby, D E, Giacca, M, O'Carroll, D, Hadoke, P W F, Denby, L, Sluimer, J & Baker, A H 2021, ' CARMN loss regulates smooth muscle cells and accelerates atherosclerosis in mice ', Circulation Research . https://doi.org/10.1161/CIRCRESAHA.120.318688

Rationale: In the microenvironment of atherosclerotic lesions, vascular smooth muscle cells (vSMCs) switch to a dedifferentiated state but the underlying molecular mechanisms driving this switch are not fully understood. Long noncoding RNAs (lncRNAs)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a063da92ff3f8a5f5bd2d890fd58e0a8
https://cris.maastrichtuniversity.nl/en/publications/4ec7ec20-c0da-4df0-94b7-baacd107e01e

Single-cell RNA-seq profiling of mouse endothelial cells in response to pulmonary arterial hypertension

Autor: Peter Carmeliet, Robert Lafyatis, Mark Southwood, João P Monteiro, Katherine M Ross Stewart, Andrew H. Baker, Ana-Mishel Spiroski, Mairi Brittan, Jessica P. Scanlon, Neil C. Henderson, Paul D. Upton, Kevin Stewart, Shiau Haln Chen, Patrick W. F. Hadoke, Sweta Sweta, Ziwen Li, Alena Shmakova, Adam Handen, Stephen D Moore, Julie Rodor, Stephen Y. Chan, Axelle Caudrillier, Ross Dobie, Laura P.M.H. de Rooij, Beth Ep Henderson, Nicholas W. Morrell

Publikováno v: Rodor, J, Chen, S H, Scanlon, J P, Monteiro, J P, Caudrillier, A, Sweta, S, Ross Stewart, K, Shmakova, A, Dobie, R, Henderson, B EP, Stewart, K, Hadoke, P W F, Southwood, M, Moore, S D, Upton, P D, Morrell, N W, Li, Z, Chan, S Y, Handen, A, Lafyatis, R, de Rooij, L P M H, Henderson, N C, Carmeliet, P, Spiroski, A-M, Brittan, M & Baker, A H 2021, ' Single-cell RNA-seq profiling of mouse endothelial cells in response to pulmonary arterial hypertension ', Cardiovascular Research . https://doi.org/10.1093/cvr/cvab296

AimsEndothelial cell (EC) dysfunction drives the initiation and pathogenesis of pulmonary arterial hypertension (PAH). We aimed to characterize EC dynamics in PAH at single-cell resolution.Methods and resultsWe carried out single-cell RNA sequencing

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::891a9d5ea79aa7f348c696c61724c06b
https://www.pure.ed.ac.uk/ws/files/227519929/cvab296.pdf

The Human-Specific and Smooth Muscle Cell-Enriched lncRNA SMILR Promotes Proliferation by Regulating Mitotic CENPF mRNA and Drives Cell-Cycle Progression Which Can Be Targeted to Limit Vascular Remodeling

Autor: Judith C. Sluimer, Gwyn W. Gould, Adriana Tavares, John Hung, Julie Rodor, Jean Iyinikkel, Andrea Caporali, Jessica P. Scanlon, Andrew H. Baker, Amira D. Mahmoud, Angela C. Bradshaw, Jakub Kaczynski, Sarah J George, Nicholas L. Mills, Margaret D. Ballantyne, David E. Newby, Vladislav Miscianinov, Igor Ulitsky, Karine Pinel

Publikováno v: Mahmoud, A, Ballantyne, M, Miscianinov, V, Pinel, K, Hung, J, Scanlon, J, Iyinikkel, J, Kaczynski, J, Tavares, A, Bradshaw, A, Mills, N, Newby, D, Caporali, A, Gould, G, George, S, Vlitsky, I, Sluimer, J, Rodor, J & Baker, A 2019, ' The Human-Specific and Smooth Muscle Cell-Enriched lncRNA SMILR Promotes Proliferation by Regulating Mitotic CENPF mRNA and Drives Cell-Cycle Progression Which Can Be Targeted to Limit Vascular Remodeling ', Circulation Research, vol. 125 (2019), no. 5, pp. 535-551 . https://doi.org/10.1161/CIRCRESAHA.119.314876
Circulation Research
Mahmoud, A D, Ballantyne, M D, Miscianinov, V, Pinel, K, Hung, J, Scanlon, J P, Iyinikkel, J, Kaczynski, J, Tavares, A S, Bradshaw, A C, Mills, N L, Newby, D E, Caporali, A, Gould, G W, George, S J, Ulitsky, I, Sluimer, J C, Rodor, J & Baker, A H 2019, ' The Human-Specific and Smooth Muscle Cell-Enriched LncRNA SMILR Promotes Proliferation by Regulating Mitotic CENPF mRNA and Drives Cell-Cycle Progression Which Can Be Targeted to Limit Vascular Remodeling. ', Circulation Research, vol. 125, no. 5, pp. 535–551 . https://doi.org/10.1161/CIRCRESAHA.119.314876
Circulation Research, 125(5), 535-551. LIPPINCOTT WILLIAMS & WILKINS

Supplemental Digital Content is available in the text.
Rationale: In response to blood vessel wall injury, aberrant proliferation of vascular smooth muscle cells (SMCs) causes pathological remodeling. However, the controlling mechanisms are not

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3db9b4e191ff20deb4144190fe9adafc
https://hdl.handle.net/1983/05c13a0a-7a05-4472-b9bc-5cf31b10c451

Poly(A)-binding proteins and mRNA localization: who rules the roost?

Autor: Richard P. Smith, Lenka Hrabalkova, Jessica P. Scanlon, Nicola K. Gray

Publikováno v: Biochemical Society transactions. 43(6)

RNA-binding proteins are often multifunctional, interact with a variety of protein partners and display complex localizations within cells. Mammalian cytoplasmic poly(A)-binding proteins (PABPs) are multifunctional RNA-binding proteins that regulate

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b9d89b178193ae6aa99b64bfbbe86fa9
https://pubmed.ncbi.nlm.nih.gov/26614673