Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Jessica P. Alexander"'
Autor:
Samuel Frank, Karen E. Anderson, Hubert H. Fernandez, Robert A. Hauser, Daniel O. Claassen, David Stamler, Stewart A. Factor, Joohi Jimenez-Shahed, Hadas Barkay, Amanda Wilhelm, Jessica K. Alexander, Nayla Chaijale, Steve Barash, Juha-Matti Savola, Mark Forrest Gordon, Maria Chen
Publikováno v:
Neurology and Therapy, Vol 13, Iss 3, Pp 655-675 (2024)
Abstract Introduction Deutetrabenazine is a vesicular monoamine transporter 2 inhibitor used to treat tardive dyskinesia (TD) and chorea associated with Huntington disease (HD). To enhance detection of safety signals across individual trials, integra
Externí odkaz:
https://doaj.org/article/86f74f75204d4fddb3bf5d6367615519
Publikováno v:
Jurnal Komunikasi Indonesia, Vol 10, Iss 2 (2021)
Externí odkaz:
https://doaj.org/article/e7cd4d187bbc49dcacc9b980c18d76ff
Publikováno v:
MediaTor, Vol 12, Iss 2 (2019)
The @ffa_com Instagram account utilizes social media to provide an understanding of harassment and campaign for anti-harassment movements to its followers. This movement being done since there is still lack of understanding of abuse cases . The purpo
Externí odkaz:
https://doaj.org/article/d48123c9d39a4ad4941d3adbf61a3f5d
Autor:
Gary P. O'Neill, Todd K. Jones, Olivia D. Weber, Cheryl A. Grice, Cassandra L. Henry, Justin S. Cisar, Jacqueline L. Blankman, Jessica P. Alexander, R. Alan B. Ezekowitz, Jason R. Clapper, Gabriel M. Simon
Publikováno v:
Journal of medicinal chemistry. 61(20)
The serine hydrolase monoacylglycerol lipase (MGLL) converts the endogenous cannabinoid receptor agonist 2-arachidonoylglycerol (2-AG) and other monoacylglycerols into fatty acids and glycerol. Genetic or pharmacological inactivation of MGLL leads to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe3392790c41c15f6717038b3ed265c3
https://pubmed.ncbi.nlm.nih.gov/30067909
https://pubmed.ncbi.nlm.nih.gov/30067909
Autor:
Gabriel M. Simon, Cheryl A. Grice, Micah J. Niphakis, Olivia D. Weber, R. Alan B. Ezekowitz, Nhi Ngo, Rachel A. Herbst, Jason R. Clapper, Justin S. Cisar, Iain P. Fraser, Jacqueline L. Blankman, Dylan M. Herbst, Mark L. Cunningham, Gary P. O'Neill, Todd K. Jones, Anna M. Knize, Alex Reed, Cassandra L. Henry, Aundrea R. Coppola, Andreu Viader, Jessica P. Alexander
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 367(3)
Monoacylglycerol lipase (MGLL) is the primary degradative enzyme for the endocannabinoid 2-arachidonoylglycerol (2-AG). The first MGLL inhibitors have recently entered clinical development for the treatment of neurologic disorders. To support this cl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef38160293a49bd7fff58ad8eba72dc0
https://pubmed.ncbi.nlm.nih.gov/30305428
https://pubmed.ncbi.nlm.nih.gov/30305428
Autor:
Emily Hickey, Stella H. Vincent, Hongshi Yu, John H. Shin, Michael A. Crackower, Hyun-Hee Lee, Malgorzata A Gil, Michael Caniga, Jessica P. Alexander, Lily Y. Moy, Alan B. Northrup, Gissela Lieber, Richard L. Miller, Richard W. Chapman, Erich E Sirkowski, Thomas A. Miller, Yanlin Jia, Hani Houshyar, Nancy Kelly, J. Michael Ellis, Xiomara Fernandez, Alan Wilhelm, Hongmin Chen, William M. Abraham
Publikováno v:
American Journal of Respiratory Cell and Molecular Biology. 49:1085-1092
Spleen tyrosine kinase (SYK) is a key activator of signaling pathways downstream of multiple surface receptors implicated in asthma. SYK function has been extensively studied in mast cells downstream of the high-affinity IgE receptor, FcεR1. Preclin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f62d70a91ae24da5195de5671fc3542c
https://doi.org/10.1165/rcmb.2013-0200oc
https://doi.org/10.1165/rcmb.2013-0200oc
Autor:
Susan Fung, Ken Mackie, Grace Woodruff, Eric A. Horne, Ágnes L. Bodor, Jacqueline L. Blankman, Jessica P. Alexander, Thomas Möller, Nephi Stella, Jonathan Coy, Aurore Thomazeau, Weiwei Li, Sherry Shu Jung Hu, Olivier J. Manzoni, Benjamin F. Cravatt, Giulio G. Muccioli, William R. Marrs, Yi Hsing Lin, Jonathan Z. Long, Mathieu Lafourcade, Cong Xu
Publikováno v:
Nature Neuroscience, Vol. 13, no. 8, p. 951-7 (2010)
Nature Neuroscience
Nature Neuroscience, 2010, 13 (8), pp.951-957. ⟨10.1038/nn.2601⟩
Nature Neuroscience
Nature Neuroscience, 2010, 13 (8), pp.951-957. ⟨10.1038/nn.2601⟩
International audience; The endocannabinoid 2-arachidonoylglycerol (2-AG) regulates neurotransmission and neuroinflammation by activating CB1 cannabinoid receptors on neurons and CB2 cannabinoid receptors on microglia. Enzymes that hydrolyze 2-AG, su
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e57535df1cdec0bb8ed0906959b18e96
https://doi.org/10.1038/nn.2601
https://doi.org/10.1038/nn.2601
γ-Glutamyl Hydrolase: Kinetic Characterization of Isopeptide Hydrolysis Using Fluorogenic Substrates
Publikováno v:
Biochemistry. 47:1228-1239
Gamma-glutamyl hydrolase, a cysteine peptidase, catalyzes the hydrolysis of poly-gamma-glutamate derivatives of folate cofactors and many antifolate drugs. We have used internally quenched fluorogenic derivatives of glutamyl-gamma-glutamate and (4,4-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::abc3c5d8d1a5d654e10ad37d137dca0d
https://doi.org/10.1021/bi701607v
https://doi.org/10.1021/bi701607v
Autor:
Andrea Arendse, Tracy Stevenson, Tyzoon K. Nomanbhoy, Marya Liimatta, Jessica P. Alexander, Douglas S. Johnson, Laura R Fitzgerald, Kyunghye Ahn, Richard A. Nugent, Benjamin F. Cravatt, Eric T Lund
Publikováno v:
Biochemistry. 46:13019-13030
Fatty acid amide hydrolase (FAAH) is an integral membrane enzyme that degrades the fatty acid amide family of signaling lipids, including the endocannabinoid anandamide. Genetic or pharmacological inactivation of FAAH leads to analgesic, anti-inflamm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad909ffb5b6b153db3de6df04798ba43
https://doi.org/10.1021/bi701378g
https://doi.org/10.1021/bi701378g
Publikováno v:
Chemistry & Biology. 12(11):1179-1187
SummaryFatty acid amide hydrolase (FAAH) regulates a large class of signaling lipids, including the endocannabinoid anandamide. Carbamate inhibitors of FAAH display analgesic and anxiolytic properties in rodents. However, the mechanism by which carba
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::046f1e8d49487e13651d6044aae059d2