Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Jessica Orf"'
Autor:
Chih-Chien Chou, Jordan Kardos, Becky Yang, Jessica Orf, Rutwij Dave, Yurong Lai, Chingwei V. Lee, Giuseppe A. Papalia, Kelli Boyd, Lauri Diehl, Nathalie Scholler
Publikováno v:
Cancer Research. 83:P4-07
Background: Sacituzumab govitecan (SG, Trodelvy®) is a human trophoblast cell surface antigen 2 (TROP-2) directed antibody drug conjugate (ADC) coupled to an active form of irinotecan (SN-38) via our novel hydrolyzable linker (CL2A). SG is the only
Autor:
Jennie C. Kim, Xian Liu, Karen Fitzgerald, Jason S. Eng, Jessica Orf, Sarah A. O’Brien, Brian Belmontes, Amy-Jo Casbon, Sergey V. Novitskiy, Kristin V. Tarbell, Jason DeVoss, Jackson G. Egen
Publikováno v:
Cancer Immunology, Immunotherapy. 72:1327-1335
Type I interferon-mediated activation of immune cells can facilitate the generation of productive tumor antigen-specific T cell responses in solid tumors. The cGAS/STING DNA sensing pathway is a critical upstream mediator of type I interferon product
Autor:
Kang Dai, Dineli Wickramasinghe, Alexander Kamb, Julio Medina, Lawrence R. McGee, Christophe Quéva, Timothy Carlson, Lily Liu, Ada Chen, Rachel Ngo, Sharon Zhao, Mei-Chu Lo, Jessica Orf, Grace Alba, Xianghong Wang, Justin Huard, Margaret Weidner, Lingming Liang, John Eksterowicz, David Hollenback, Suzanne Coberly, Mark Ragains, Ji Ma, Zhihong Li, Cong Li, Kathleen Keegan
PDF file - 132KB, Figure S1. Plasma concentration-time profiles of AMG 925 in rat, dog, and cynomolgus monkey following oral administration. Figure S2. Inhibition of STAT5 and Rb phosphorylation by AMG 925 in MOLM13-Luc tumor cells in bone marrow. Ta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::216ae1da07e58a29878dbe9dcd4275af
https://doi.org/10.1158/1535-7163.22499853
https://doi.org/10.1158/1535-7163.22499853
Autor:
Alison H. Joly, Yu-Chien Chou, Justin Lesch, Lillian Lee, Stefan Engst, A. Douglas Laird, Andrew You, Jessica Orf, Belinda Cancilla, Frauke Bentzien, Felix Chu, Fawn Qian, Peiwen Yu, Yongchang Shi, Kyoko Yamaguchi, Jenny Tan, Jason Chen, F. Michael Yakes
PDF file - 104KB
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54cd3621fbfa51d438f48142646da225
https://doi.org/10.1158/1535-7163.22496638.v1
https://doi.org/10.1158/1535-7163.22496638.v1
Autor:
Alison H. Joly, Yu-Chien Chou, Justin Lesch, Lillian Lee, Stefan Engst, A. Douglas Laird, Andrew You, Jessica Orf, Belinda Cancilla, Frauke Bentzien, Felix Chu, Fawn Qian, Peiwen Yu, Yongchang Shi, Kyoko Yamaguchi, Jenny Tan, Jason Chen, F. Michael Yakes
The signaling pathway of the receptor tyrosine kinase MET and its ligand hepatocyte growth factor (HGF) is important for cell growth, survival, and motility and is functionally linked to the signaling pathway of VEGF, which is widely recognized as a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e1c0549987b6953fbcc1b2686b81a276
https://doi.org/10.1158/1535-7163.c.6535348
https://doi.org/10.1158/1535-7163.c.6535348
Autor:
Chih-Chien Chou, Dmytro Kornyeyev, Becky Yang, Jessica Orf, Hai-Ling Sun, Rutwij Dave, Yurong Lai, Giuseppe Papalia, Thomas Cardillo, Nathalie Scholler
Publikováno v:
Regular and Young Investigator Award Abstracts.
Autor:
Jennie C, Kim, Xian, Liu, Karen, Fitzgerald, Jason S, Eng, Jessica, Orf, Sarah A, O'Brien, Brian, Belmontes, Amy-Jo, Casbon, Sergey V, Novitskiy, Kristin V, Tarbell, Jason, DeVoss, Jackson G, Egen
Publikováno v:
Cancer immunology, immunotherapy : CII.
Type I interferon-mediated activation of immune cells can facilitate the generation of productive tumor antigen-specific T cell responses in solid tumors. The cGAS/STING DNA sensing pathway is a critical upstream mediator of type I interferon product
Publikováno v:
Journal of Biological Methods
Bone marrow chimeras represent a key tool employed to understand biological contributions stemming from the hematopoietic versus the stromal compartment. In most institutions, cesium irradiators are used to lethally irradiate recipient animals prior
Autor:
Jason DeVoss, Juan Estrada, Jing Qing, Meisen Walter Hans, Christina de Zafra, Jinghui Zhan, Peng Li, Keegan Cooke, Petia Mitchell, Jessica Orf
Publikováno v:
Cancer Research. 81:1586-1586
Oncolytic virotherapy is an emerging treatment modality that may hold promise as a therapeutic option for cancer patients who do not respond to checkpoint inhibitors. Oncolytic viruses preferentially replicate in tumor cells, offer the ability to exp
Autor:
Shan Wang, Aaron S. Rapaport, Yao He, Daniel Lu, Xin Yu, Lynn Wang, Yingjiang Ye, Jackson G. Egen, Xueda Hu, Qiao Fang, Ranran Gao, Lei Zhang, Xianwen Ren, Jessica Orf, Aeryon Kim, Wenjun Ouyang, Qiming Zhang, Deepali V. Sawant, Wei Zhang, Chi-Ming Li, Katarzyna M. Skrzypczynska, Kristy Perez, Zhanlong Shen, Jiajinlong Kang, Ziyi Li, Dev Bhatt, Sarah A. O’Brien, Zemin Zhang, Tao Wang
Publikováno v:
Cell. 181(2)
Summary Single-cell RNA sequencing (scRNA-seq) is a powerful tool for defining cellular diversity in tumors, but its application toward dissecting mechanisms underlying immune-modulating therapies is scarce. We performed scRNA-seq analyses on immune