Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Jessica N. Spradlin"'
Autor:
Patrick Moon, Charlotte M. Zammit, Qian Shao, Dustin Dovala, Lydia Boike, Nathaniel J. Henning, Mark Knapp, Jessica N. Spradlin, Carl C. Ward, Helene Wolleb, Daniel Fuller, Gabrielle Blake, Jason P. Murphy, Feng Wang, Yipin Lu, Stephanie A. Moquin, Laura Tandeske, Matthew J. Hesse, Jeffrey M. McKenna, John A. Tallarico, Markus Schirle, F. Dean Toste, Daniel K. Nomura
Publikováno v:
ChemBioChem.
Autor:
Annika C. S. Page, Spencer O. Scholz, Katherine N. Keenan, Jessica N. Spradlin, Bridget P. Belcher, Scott M. Brittain, John A. Tallarico, Jeffrey M. McKenna, Markus Schirle, Daniel K. Nomura, F. Dean Toste
Publikováno v:
Chemical science, vol 13, iss 13
Photoaffinity labeling (PAL) is a powerful tool for the identification of non-covalent small molecule-protein interactions that are critical to drug discovery and medicinal chemistry, but this approach is limited to only a small subset of robust phot
Autor:
Nathaniel J. Henning, Andrew G. Manford, Jessica N. Spradlin, Scott M. Brittain, Erika Zhang, Jeffrey M. McKenna, John A. Tallarico, Markus Schirle, Michael Rape, Daniel K. Nomura
Publikováno v:
J Am Chem Soc
Proteolysis Targeting Chimeras (PROTACs), heterobifunctional compounds that consist of protein-targeting ligands linked to an E3 ligase recruiter, have arisen as a powerful therapeutic modality for targeted protein degradation (TPD). Despite the popu
Autor:
Nathaniel J. Henning, Scott M. Brittain, Lynn M. McGregor, John A. Tallarico, Hesse M, Carl C. Ward, Bridget P. Belcher, Lydia Boike, Jessica N. Spradlin, Markus Schirle, Jeffery M. McKenna, Dustin Dovala, Daniel K. Nomura
Targeted protein degradation is a powerful therapeutic modality that uses heterobifunctional small-molecules to induce proximity between E3 ubiquitin ligases and target proteins to ubiquitinate and degrade specific proteins of interest. However, many
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::38f2a0ff703641e9a40022f756281844
https://doi.org/10.1101/2021.04.30.441959
https://doi.org/10.1101/2021.04.30.441959
Autor:
Nathaniel J. Henning, Lydia Boike, Jessica N. Spradlin, Carl C. Ward, Gang Liu, Erika Zhang, Bridget P. Belcher, Scott M. Brittain, Matthew J. Hesse, Dustin Dovala, Lynn M. McGregor, Rachel Valdez Misiolek, Lindsey W. Plasschaert, David J. Rowlands, Feng Wang, Andreas O. Frank, Daniel Fuller, Abigail R. Estes, Katelyn L. Randal, Anoohya Panidapu, Jeffrey M. McKenna, John A. Tallarico, Markus Schirle, Daniel K. Nomura
Publikováno v:
Nature chemical biology, vol 18, iss 4
Many diseases are driven by proteins that are aberrantly ubiquitinated and degraded. These diseases would be therapeutically benefited by targeted protein stabilization (TPS). Here we present deubiquitinase-targeting chimeras (DUBTACs), heterobifunct
Autor:
John A. Tallarico, Jessica N. Spradlin, Scott M. Brittain, Michael Rape, Markus Schirle, Daniel K. Nomura, Jeffery M. McKenna, Andrew G. Manford, Nathaniel J. Henning
Proteolysis Targeting Chimeras (PROTACs), heterobifunctional compounds that consist of protein-targeting ligands linked to an E3 ligase recruiter, have arisen as a powerful therapeutic modality for targeted protein degradation (TPD). Despite the popu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::15554b8f90fe83d96da1d76719b9f0ed
https://doi.org/10.1101/2021.04.15.439993
https://doi.org/10.1101/2021.04.15.439993
Publikováno v:
Accounts of chemical research. 54(7)
One of the biggest bottlenecks in modern drug discovery efforts is in tackling the undruggable proteome. Currently, over 85% of the proteome is still considered undruggable because most proteins lack well-defined binding pockets that can be functiona
Autor:
Sarah A. Stanley, Carl C. Ward, Thomas G.W. Graham, Xammy Nguyenla, Allison W. Roberts, Jessica N. Spradlin, Scott B. Biering, Teena Bajaj, Douglas M. Fox, Julien R. Stroumza, Eddie Wehri, Melanie Ott, Ursula Schulze-Gamen, Claire Dugast-Darzacq, Guillaume Golovkine, Julia Schaletzky, Daniel M. Fines, Ruchika Bajaj, Erik Van Dis, Dustin Dovala, Daniel K. Nomura, Lívia H. Yamashiro, Niren Murthy
Publikováno v:
ACS infectious diseases, vol 7, iss 8
ACS Infectious Diseases
ACS Infectious Diseases
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of coronavirus disease 2019 (COVID-19), has emerged as a major global health threat. The COVID-19 pandemic has resulted in over 80 million cases and 1.7 million deaths
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e9fe6ba50a981efa16dab519e4db30b
https://doi.org/10.1101/2020.12.30.424862
https://doi.org/10.1101/2020.12.30.424862
Autor:
Thomas J. Maimone, Jeffrey Mckenna, Jessica N. Spradlin, Yi Xie, John A. Tallarico, Mai Luo, Daniel K. Nomura, Markus Schirle, Bingqi Tong
Publikováno v:
Scientific Reports
Scientific reports, vol 10, iss 1
Scientific Reports, Vol 10, Iss 1, Pp 1-8 (2020)
Scientific reports, vol 10, iss 1
Scientific Reports, Vol 10, Iss 1, Pp 1-8 (2020)
Targeted protein degradation (TPD) has emerged as a powerful tool in drug discovery for the perturbation of protein levels using heterobifunctional small molecules. E3 ligase recruiters remain central to this process yet relatively few have been iden
Autor:
Jessica N. Spradlin, John A. Tallarico, Scott M. Brittain, Mai Luo, Lydia Boike, Bingqi Tong, Jeffrey Mckenna, Markus Schirle, Dan Nomura, Thomas J. Maimone
The translation of natural product function to fully synthetic small molecules has remained an important process in medicinal chemistry for decades resulting in numerous FDA-approved medicines. We recently discovered that the terpene natural product
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d6b0edb0ba89469c35ff59fcd51f81c7
https://doi.org/10.1101/2020.07.12.198150
https://doi.org/10.1101/2020.07.12.198150