Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Jessica N. Lancaster"'
Autor:
Tina Kwok, Shannon C. Medovich, Ildefonso A. Silva-Junior, Elise M. Brown, Joel C. Haug, Marliece R. Barrios, Karina A. Morris, Jessica N. Lancaster
Publikováno v:
Frontiers in Aging, Vol 3 (2022)
The decreased proportion of antigen-inexperienced, naïve T cells is a hallmark of aging in both humans and mice, and contributes to reduced immune responses, particularly against novel and re-emerging pathogens. Naïve T cells depend on survival sig
Externí odkaz:
https://doaj.org/article/72e8d96cfa61433b98a1261c1fd90878
Autor:
Jayashree Srinivasan, Jessica N. Lancaster, Nandini Singarapu, Laura P. Hale, Lauren I. R. Ehrlich, Ellen R. Richie
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Thymic epithelial cells (TECs) and hematopoietic antigen presenting cells (HAPCs) in the thymus microenvironment provide essential signals to self-reactive thymocytes that induce either negative selection or generation of regulatory T cells (Treg), b
Externí odkaz:
https://doaj.org/article/051e6390cc1b4809b02d130a805425df
Autor:
Yuxiang Zhu, Tina Kwok, Joel C. Haug, Shenghan Guo, Xiangfan Chen, Weiheng Xu, Dharneedar Ravichandran, Yourka D. Tchoukalova, Jeffrey L. Cornella, Johnny Yi, Orit Shefi, Brent L. Vernon, David G. Lott, Jessica N. Lancaster, Kenan Song
Publikováno v:
Advanced Materials Technologies. 8
Autor:
Jessica N. Lancaster, Damaris E. Keatinge‐Clay, Jayashree Srinivasan, Yu Li, Hilary J. Selden, Seohee Nam, Ellen R. Richie, Lauren I. R. Ehrlich
Publikováno v:
Aging cell. 21(6)
One of the earliest hallmarks of immune aging is thymus involution, which not only reduces the number of newly generated and exported T cells, but also alters the composition and organization of the thymus microenvironment. Thymic T-cell export conti
Publikováno v:
The Journal of Immunology. 208:167.05-167.05
The decreased proportion of antigen-inexperienced, naïve T cells is a hallmark of aging in both humans and mice, and contributes to reduced immune responses, particularly against novel and re-emerging pathogens. Naïve T cells depend on survival sig
Publikováno v:
Trends in Immunology. 39:86-98
As they differentiate, thymocytes encounter spatially restricted cues critical for differentiation and selection of a functional, self-tolerant T cell repertoire. Sequential migration of developing T cells through distinct thymic microenvironments is
Publikováno v:
The Journal of Immunology. 206:108.07-108.07
Central tolerance is established as T cells mature in the thymus by the combined effects of clonally deleting autoreactive thymocytes or inducing their diversion to the Treg lineage. To ensure T cell tolerance to diverse self-antigens, thymocytes mus
Autor:
Zicheng Hu, Hiran M. Thyagarajan, Lauren I.R. Ehrlich, Yu Li, Jayashree Srinivasan, Jessica N. Lancaster
Publikováno v:
Nature Communications
Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
Both medullary thymic epithelial cells (mTEC) and dendritic cells (DC) present tissue-restricted antigens (TRA) to thymocytes to induce central tolerance, but the relative contributions of these antigen-presenting cell (APC) subsets remain unresolved
Autor:
Jessica N Lancaster, Jayashree Srinivasan, Hilary J. Selden, Seohee Nam, Lauren Ilyse Richie Ehrlich
Publikováno v:
The Journal of Immunology. 204:62.4-62.4
During aging, the thymus undergoes involution, decreasing dramatically in size and mass, and becoming increasingly disorganized. Notably, thymic epithelial cells decline with age, especially within the compartment of mature medullary thymic epithelia
Autor:
Yu Li, Jessica N Lancaster, Seo Hee Nam, Hyemin Seo, Hilary J. Selden, Lauren Ilyse Richie Ehrlich
Publikováno v:
The Journal of Immunology. 204:59.5-59.5
Central tolerance mechanisms, including clonal deletion and Treg selection, are required to remove autoreactive T cells generated during thymocyte differentiation. To ensure T cell tolerance to diverse self-antigens, the majority of the peptidome is