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pro vyhledávání: '"Jessica Mpamugo"'
Autor:
Pankaj Pathak, Yotam Blech-Hermoni, Kalpana Subedi, Jessica Mpamugo, Charissa Obeng-Nyarko, Rachel Ohman, Ilda Molloy, Malcolm Kates, Jessica Hale, Stacey Stauffer, Shyam K. Sharan, Ami Mankodi
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-15 (2021)
Pathak et al. identify LDB3, a striated muscle PDZ-LIM protein, as a signaling adaptor in a major mechanosensor assembly through interactions with filamin C, HSPA8, and PKCα. When LDB3 is mutated, PKCα and TSC2-mTOR mediated homeostasis is impaired
Externí odkaz:
https://doaj.org/article/d4e302a88eb748a8be9622e9386d26e5
Autor:
Yotam Blech-Hermoni, Jessica Hale, Pankaj Pathak, Rachel Ohman, Malcolm Kates, Kalpana Subedi, Stacey Stauffer, Ilda Molloy, Jessica Mpamugo, Charissa Obeng-Nyarko, Shyam K. Sharan, Ami Mankodi
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-15 (2021)
Communications Biology
Communications Biology
Mechanical stress induced by contractions constantly threatens the integrity of muscle Z-disc, a crucial force-bearing structure in striated muscle. The PDZ-LIM proteins have been proposed to function as adaptors in transducing mechanical signals to