Zobrazeno 1 - 10
of 47
pro vyhledávání: '"Jessica Marinello"'
Autor:
Mathéa Geraud, Agnese Cristini, Simona Salimbeni, Nicolas Bery, Virginie Jouffret, Marco Russo, Andrea Carla Ajello, Lara Fernandez Martinez, Jessica Marinello, Pierre Cordelier, Didier Trouche, Gilles Favre, Estelle Nicolas, Giovanni Capranico, Olivier Sordet
Publikováno v:
Cell Reports, Vol 43, Iss 5, Pp 114214- (2024)
Summary: TDP1 removes transcription-blocking topoisomerase I cleavage complexes (TOP1ccs), and its inactivating H493R mutation causes the neurodegenerative syndrome SCAN1. However, the molecular mechanism underlying the SCAN1 phenotype is unclear. He
Externí odkaz:
https://doaj.org/article/d37f0288c1ca4085bf68d93fbf8946d1
Publikováno v:
Molecular Cancer, Vol 21, Iss 1, Pp 1-15 (2022)
Abstract G-quadruplex (G4) binders have been investigated to discover new anticancer drugs worldwide in past decades. As these ligands are generally not highly cytotoxic, the discovery rational was mainly based on increasing the cell-killing potency.
Externí odkaz:
https://doaj.org/article/15105bdac8f44c51933a749556b9106f
Autor:
Stefano G. Manzo, Stella R. Hartono, Lionel A. Sanz, Jessica Marinello, Sara De Biasi, Andrea Cossarizza, Giovanni Capranico, Frederic Chedin
Publikováno v:
Genome Biology, Vol 19, Iss 1, Pp 1-18 (2018)
Abstract Background Co-transcriptional R-loops are abundant non-B DNA structures in mammalian genomes. DNA Topoisomerase I (Top1) is often thought to regulate R-loop formation owing to its ability to resolve both positive and negative supercoils. How
Externí odkaz:
https://doaj.org/article/d230920f9e4044538f0d8cb487c07b20
Autor:
Agnese Cristini, Giulia Ricci, Sébastien Britton, Simona Salimbeni, Shar-yin Naomi Huang, Jessica Marinello, Patrick Calsou, Yves Pommier, Gilles Favre, Giovanni Capranico, Natalia Gromak, Olivier Sordet
Publikováno v:
Cell Reports, Vol 28, Iss 12, Pp 3167-3181.e6 (2019)
Summary: Although accumulation of DNA damage and genomic instability in resting cells can cause neurodegenerative disorders, our understanding of how transcription produces DNA double-strand breaks (DSBs) is limited. Transcription-blocking topoisomer
Externí odkaz:
https://doaj.org/article/1021112fc04b439383b6092523d8e7f5
Autor:
Jessica Marinello, Stefania Bertoncini, Iris Aloisi, Agnese Cristini, Guidantonio Malagoli Tagliazucchi, Mattia Forcato, Olivier Sordet, Giovanni Capranico
Publikováno v:
PLoS ONE, Vol 11, Iss 1, p e0147053 (2016)
Topoisomerase I-DNA-cleavage complexes (Top1cc) stabilized by camptothecin (CPT) have specific effects at transcriptional levels. We recently reported that Top1cc increase antisense transcript (aRNAs) levels at divergent CpG-island promoters and, tra
Externí odkaz:
https://doaj.org/article/56b6b2a2bceb4d119514f74157abb240
Publikováno v:
International Journal of Molecular Sciences, Vol 19, Iss 11, p 3480 (2018)
Mammalian DNA topoisomerases II are targets of anticancer anthracyclines that act by stabilizing enzyme-DNA complexes wherein DNA strands are cut and covalently linked to the protein. This molecular mechanism is the molecular basis of anthracycline a
Externí odkaz:
https://doaj.org/article/600e29841c0147a6b3c6dba0880f97e5
Autor:
Malgorzata N Drwal, Jessica Marinello, Stefano G Manzo, Laurence P G Wakelin, Giovanni Capranico, Renate Griffith
Publikováno v:
PLoS ONE, Vol 9, Iss 12, p e114904 (2014)
DNA topoisomerases are enzymes responsible for the relaxation of DNA torsional strain, as well as for the untangling of DNA duplexes after replication, and are important cancer drug targets. One class of topoisomerase inhibitors, "poisons", binds to
Externí odkaz:
https://doaj.org/article/75a838a2129a44aca3535bd15f6fa9a6
Autor:
Ze-Hong Miao, Giovanni Capranico, Jian Ding, Yuan-Chao Li, Jin-Xue He, Jessica Marinello, Ying-Qing Wang, Zhao-Li Zhou, Stefano Giustino Manzo
PDF file - 796K, SK-OV-3, HCC1937, 786-O, MDA-MB-436, and HCC1937 cells exposed to triptolide, then harvested by Western blotting
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b13d961e3903dd883ab4c31a00308a3
https://doi.org/10.1158/0008-5472.22394003
https://doi.org/10.1158/0008-5472.22394003
Autor:
Ze-Hong Miao, Giovanni Capranico, Jian Ding, Yuan-Chao Li, Jin-Xue He, Jessica Marinello, Ying-Qing Wang, Zhao-Li Zhou, Stefano Giustino Manzo
PDF file - 1.1MB, Cells were treated with gradient concentrations of triptolide, then harvested by Western blotting
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0506f0e18d97c5105b6f52a354b644ea
https://doi.org/10.1158/0008-5472.22394006
https://doi.org/10.1158/0008-5472.22394006
Autor:
Ze-Hong Miao, Giovanni Capranico, Jian Ding, Yuan-Chao Li, Jin-Xue He, Jessica Marinello, Ying-Qing Wang, Zhao-Li Zhou, Stefano Giustino Manzo
Triptolide is a bioactive ingredient in traditional Chinese medicine that exhibits diverse biologic properties, including anticancer properties. Among its many putative targets, this compound has been reported to bind to XPB, the largest subunit of g
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::50a27a9bb3122eddbf0b4131043c0301
https://doi.org/10.1158/0008-5472.c.6503924.v1
https://doi.org/10.1158/0008-5472.c.6503924.v1