Výsledky vyhledávání - "Jessica Mancuso"

Akademický článek

Investigation of pharmacokinetic drug interaction between clesacostat and DGAT2 inhibitor ervogastat in healthy adult participants

Autor: Aarti Sawant‐Basak, Arthur J. Bergman, Jessica Mancuso, Sakambari Tripathy, James R. Gosset, Laure Mendes da Costa, William P. Esler, Roberto A. Calle

Publikováno v: Clinical and Translational Science, Vol 17, Iss 2, Pp n/a-n/a (2024)

Abstract Co‐administration of clesacostat (acetyl‐CoA carboxylase inhibitor, PF‐05221304) and ervogastat (diacylglycerol O‐acyltransferase inhibitor, PF‐06865571) in laboratory models improved non‐alcoholic fatty liver disease (NAFLD)/non

Externí odkaz: https://doaj.org/article/ea4079a3b1344ca986312423c445ad90

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Akademický článek

A Phase 2 clinical trial of PF-05212377 (SAM-760) in subjects with mild to moderate Alzheimer’s disease with existing neuropsychiatric symptoms on a stable daily dose of donepezil

Autor: Terence Fullerton, Brendon Binneman, William David, Marielle Delnomdedieu, James Kupiec, Peter Lockwood, Jessica Mancuso, Jeffrey Miceli, Joanne Bell

Publikováno v: Alzheimer’s Research & Therapy, Vol 10, Iss 1, Pp 1-10 (2018)

Abstract Background Symptomatic benefits have been reported for 5-HT6 receptor antagonists in Alzheimer’s disease (AD) trials. SAM-760 is a potent and selective 5-HT6 receptor antagonist that has demonstrated central 5-HT6 receptor saturation in hu

Externí odkaz: https://doaj.org/article/cd2894dc000748f6acf781381a6cf8a7

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Efficacy and Safety of PF‐06651600 (Ritlecitinib), a Novel JAK3/TEC Inhibitor, in Patients With Moderate‐to‐Severe Rheumatoid Arthritis and an Inadequate Response to Methotrexate

Autor: Zorayr Manukyan, Deepa E. Chandra, Alan Kivitz, Michael Saunders, Christopher Banfield, Jean S. Beebe, Bojana Stamenkovic, Jessica Mancuso, Elena Peeva, Michael S. Vincent, Michael F. Robinson, Nemanja Damjanov, Lori Ann Cox, Goran Radunovic

Publikováno v: Arthritis & Rheumatology (Hoboken, N.j.)

Objective To evaluate the efficacy and safety of PF‐06651600 (ritlecitinib), an irreversible inhibitor of JAK3 and the tyrosine kinase expressed in hepatocellular carcinoma (TEC) kinase family, in comparison with placebo in patients with rheumatoid

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::080958e646c9ba5b2dfaf77a1f17b14e
https://doi.org/10.1002/art.41316

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Safety, Tolerability, Pharmacokinetics, and Pharmacodynamic Effects of PF-06751979, a Potent and Selective Oral BACE1 Inhibitor: Results from Phase I Studies in Healthy Adults and Healthy Older Subjects

Autor: Ekaterina Tankisheva, Ping He, Michael Aaron Brodney, Robert Alexander, Richard Margolin, Claire Leurent, Jessica Mancuso, Ruolun Qiu, Danny Chen, Jae Eun Ahn

Publikováno v: Journal of Alzheimer's Disease

PF-06751979 is a selective inhibitor of the beta-site amyloid precursor protein cleaving enzyme-1, which is a key aspartyl protease in the generation of amyloid-β (Aβ) peptides, thought to be critical for the cerebral degeneration observed in Alzhe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec86be9ff67e9a596041cc3d5a1abc14
https://doi.org/10.3233/jad-190228

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Prediction of Human Brain Penetration of P-glycoprotein and Breast Cancer Resistance Protein Substrates Using In Vitro Transporter Studies and Animal Models

Autor: Jessica Mancuso, Angela C. Doran, Li Di, Bo Feng, Larry M. Tremaine, Jennifer L. Liras, Sarah M. Osgood, Christopher L. Shaffer, Mark A. West

Publikováno v: Journal of Pharmaceutical Sciences. 107:2225-2235

Four P-glycoprotein (P-gp) and breast cancer resistance protein (BCRP) substrates with human cerebrospinal fluid (CSF) concentrations and preclinical neuropharmacokinetics were used to assess in vitro – in vivo extrapolation of brain penetration in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::565ea8ed038e6cad4be75faf245d15b8
https://doi.org/10.1016/j.xphs.2018.03.018

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Metabolism of a 5HT6 Antagonist, 2-Methyl-1-(Phenylsulfonyl)-4-(Piperazin-1-yl)-1H-Benzo[d]imidazole (SAM-760): Impact of Sulfonamide Metabolism on Diminution of a Ketoconazole-Mediated Clinical Drug-Drug Interaction

Autor: Angela C. Doran, Peter Lockwood, Thomas A. Comery, R. Scott Obach, Aarti Sawant-Basak, Hongying Gao, Jessica Mancuso, Susanna Tse, Klaas Schildknegt

Publikováno v: Drug Metabolism and Disposition. 46:934-942

SAM-760 [(2-methyl-1-(phenylsulfonyl)-4-(piperazin-1-yl)-1H-benzo[d]imidazole)], a 5HT6 antagonist, was investigated in humans for the treatment of Alzheimer's disease. In liver microsomes and recombinant cytochrome P450 (P450) isozymes, SAM-760 was

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f12639f175a31b7dcb982ff48b0dc0c2
https://doi.org/10.1124/dmd.118.080457

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Attenuation of ketamine-induced impairment in verbal learning and memory in healthy volunteers by the AMPA receptor potentiator PF-04958242

Autor: Jessica Mancuso, N DeMartinis, Swapnil Gupta, Deepak Cyril D'Souza, Mohini Ranganathan, John D. Cahill, B Huguenel, F Gaudreault, Martin M. Bednar, Laura Zumpano, C L Shaffer, Mohamed Sherif

Publikováno v: Molecular Psychiatry. 22:1633-1640

There is a need to develop treatments for cognitive impairment associated with schizophrenia (CIAS). The significant role played by N-methyl-d-aspartate receptors (NMDARs) in both the pathophysiology of schizophrenia and in neuronal plasticity sugges

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41fa4cc5cbdd11b2c4d28e58823a8525
https://doi.org/10.1038/mp.2017.6

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