Zobrazeno 1 - 10
of 291
pro vyhledávání: '"Jessica MANDRIOLI"'
Autor:
Marta Cozzi, Stefania Magri, Barbara Tedesco, Guglielmo Patelli, Veronica Ferrari, Elena Casarotto, Marta Chierichetti, Paola Pramaggiore, Laura Cornaggia, Margherita Piccolella, Mariarita Galbiati, Paola Rusmini, Valeria Crippa, Jessica Mandrioli, Davide Pareyson, Chiara Pisciotta, Stefano D’Arrigo, Antonia Ratti, Lorenzo Nanetti, Caterina Mariotti, Elisa Sarto, Viviana Pensato, Cinzia Gellera, Daniela Di Bella, Riccardo M. Cristofani, Franco Taroni, Angelo Poletti
Publikováno v:
Cell Death and Disease, Vol 15, Iss 9, Pp 1-16 (2024)
Abstract Mutations targeting distinct domains of the neuron-specific kinesin KIF5A associate with different neurodegenerative/neurodevelopmental disorders, but the molecular bases of this clinical heterogeneity are unknown. We characterised five key
Externí odkaz:
https://doaj.org/article/4ee9d6c2a3624724948ed40d302b0625
Autor:
Ilaria Martinelli, Jessica Mandrioli, Andrea Ghezzi, Elisabetta Zucchi, Giulia Gianferrari, Cecilia Simonini, Francesco Cavallieri, Franco Valzania
Publikováno v:
Neural Regeneration Research, Vol 20, Iss 1, Pp 130-138 (2025)
Amyotrophic lateral sclerosis (ALS) is a neuromuscular condition resulting from the progressive degeneration of motor neurons in the cortex, brainstem, and spinal cord. While the typical clinical phenotype of ALS involves both upper and lower motor n
Externí odkaz:
https://doaj.org/article/0208827a07b44cb9bfdaaf5a41d406a3
Autor:
Uri Wormser, Amnon Sintov, Marco Vinceti, Jessica Mandrioli, Berta Brodsky, Elena Proscura, Yoram Finkelstein
Publikováno v:
Exploration of Neuroprotective Therapy, Vol 3, Iss 6, Pp 435-445 (2023)
Aim: Amyotrophic lateral sclerosis (ALS) is a progressive disease of unknown etiology, characterized by degeneration of motoneurons and skeletal muscle strength decline that progressively evolves to respiratory failure and death. A key point in the t
Externí odkaz:
https://doaj.org/article/ca30e35f287e4f24ae657e0eda67576b
Autor:
Chiara Lucchi, Cecilia Simonini, Cecilia Rustichelli, Rossella Avallone, Elisabetta Zucchi, Ilaria Martinelli, Giuseppe Biagini, Jessica Mandrioli
Publikováno v:
Biomolecules, Vol 14, Iss 9, p 1076 (2024)
Produced by the mitochondria and endoplasmic reticulum, neurosteroids such as allopregnanolone are neuroprotective molecules that influence various neuronal functions and regulate neuroinflammation. They are reduced in neurodegenerative diseases, whi
Externí odkaz:
https://doaj.org/article/ab2b4827ed504f8291a0b8b04f2d834b
Autor:
Giulia Gianferrari, Elisabetta Zucchi, Ilaria Martinelli, Cecilia Simonini, Nicola Fini, Salvatore Ferro, Andrea Mercati, Laura Ferri, Tommaso Filippini, Marco Vinceti, Jessica Mandrioli
Publikováno v:
Life, Vol 14, Iss 8, p 941 (2024)
ALS is characterized by a highly heterogeneous course, ranging from slow and uncomplicated to rapid progression with severe extra-motor manifestations. This study investigated ALS-related hospitalizations and their connection to clinical aspects, com
Externí odkaz:
https://doaj.org/article/2560ef6a6b1443ffae8c1c67df3ab772
Autor:
Jessica Mandrioli, Roberto D’Amico, Elisabetta Zucchi, Sara De Biasi, Federico Banchelli, Ilaria Martinelli, Cecilia Simonini, Domenico Lo Tartaro, Roberto Vicini, Nicola Fini, Giulia Gianferrari, Marcello Pinti, Christian Lunetta, Francesca Gerardi, Claudia Tarlarini, Letizia Mazzini, Fabiola De Marchi, Ada Scognamiglio, Gianni Sorarù, Andrea Fortuna, Giuseppe Lauria, Eleonora Dalla Bella, Claudia Caponnetto, Giuseppe Meo, Adriano Chio, Andrea Calvo, Andrea Cossarizza
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-14 (2023)
Abstract In preclinical studies rapamycin was found to target neuroinflammation, by expanding regulatory T cells, and affecting autophagy, two pillars of amyotrophic lateral sclerosis (ALS) pathogenesis. Herein we report a multicenter, randomized, do
Externí odkaz:
https://doaj.org/article/b047af166d3e4b93aacae7ef3e501443
Autor:
Elisabetta Zucchi, Umberto Maria Musazzi, Guido Fedele, Ilaria Martinelli, Giulia Gianferrari, Cecilia Simonini, Nicola Fini, Andrea Ghezzi, Maria Caputo, Elisabetta Sette, Veria Vacchiano, Lucia Zinno, Pietro Anceschi, Elena Canali, Marco Vinceti, Salvatore Ferro, Jessica Mandrioli, Laura Ferri, Annalisa Gessani, Rocco Liguori, Pietro Cortelli, Roberto Michelucci, Fabrizio Salvi, Ilaria Bartolomei, Anna Maria Borghi, Andrea Zini, Rita Rinaldi, Valeria Tugnoli, Maura Pugliatti, Luca Codeluppi, Franco Valzania, Filippo Stragliati, Andi Nuredini, Sonia Romano, Alessandro D'Orsi, Liborio Parrino, Doriana Medici, Giovanna Pilurzi, Emilio Terlizzi, Donata Guidetti, Silvia De Pasqua, Mario Santangelo, Paola De Massis, Matteo Gizzi, Mario Casmiro, Pietro Querzani, Simonetta Morresi, Maria Vitiello, Marco Longoni, Alberto Patuelli, Susanna Malagù, Francesca Bianchi, Marco Currò Dossi, Cristiana Ganino
Publikováno v:
EClinicalMedicine, Vol 65, Iss , Pp 102256- (2023)
Summary: Background: Oral tauroursodeoxycholic acid (TUDCA) is a commercial drug currently tested in patients with amyotrophic lateral sclerosis (ALS) both singly and combined with sodium phenylbutyrate. This retrospective study aimed to investigate,
Externí odkaz:
https://doaj.org/article/0cb81697fbed4ad6b8eb8f12981ded73
Autor:
Giulia Vinceti, Chiara Carbone, Chiara Gallingani, Luigi Fiondella, Simone Salemme, Elisabetta Zucchi, Ilaria Martinelli, Giulia Gianferrari, Manuela Tondelli, Jessica Mandrioli, Annalisa Chiari, Giovanna Zamboni
Publikováno v:
Frontiers in Neuroscience, Vol 17 (2023)
IntroductionFrontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS) are two phenotypes of the same neurodegenerative disease, the FTD-ALS spectrum. What determines the development of one rather than the other phenotype is still unknown.
Externí odkaz:
https://doaj.org/article/0a07f5d77009446db5e0021c5ecd819e
Autor:
Ilaria Martinelli, Elisabetta Zucchi, Cecilia Simonini, Giulia Gianferrari, Giovanna Zamboni, Marcello Pinti, Jessica Mandrioli
Publikováno v:
Neural Regeneration Research, Vol 18, Iss 7, Pp 1427-1433 (2023)
Although mutations in the superoxide dismutase 1 gene account for only a minority of total amyotrophic lateral sclerosis cases, the discovery of this gene has been crucial for amyotrophic lateral sclerosis research. Since the identification of supero
Externí odkaz:
https://doaj.org/article/ee246dd0f2a449629ca302509406e48a
Autor:
Giulia Gianferrari, Ilaria Martinelli, Cecilia Simonini, Elisabetta Zucchi, Nicola Fini, Serena Carra, Cristina Moglia, Jessica Mandrioli
Publikováno v:
Frontiers in Neurology, Vol 13 (2023)
With upcoming personalized approaches based on genetics, it is important to report new mutations in amyotrophic lateral sclerosis (ALS) genes in order to understand their pathogenicity and possible patient responses to specific therapies. SOD1 mutati
Externí odkaz:
https://doaj.org/article/a882a4ec56e048ff9ed9ffb8fa98856c