Noninvasive prenatal diagnosis of Huntington disease: detection of the paternally inherited expanded CAG repeat in maternal plasma

Autor: Egbert Bakker, Elles M. J. Boon, Inge B. Mathijssen, Jessica M.E. van den Oever, Martine J. van Belzen, N. D. Muntjewerff, Ilse Feenstra, Emilia K. Bijlsma

Publikováno v: Prenatal Diagnosis. 35:945-949

OBJECTIVE: With a shift towards noninvasive testing, we have explored and validated the use of noninvasive prenatal diagnosis (NIPD) for Huntington disease (HD). METHODS: Fifteen couples have been included, assessing a total of n = 20 pregnancies. Fe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::de4770de8b39fdd1f674149d01967b64
https://doi.org/10.1002/pd.4593

Impaired Effector Memory T-Cell Regulation Facilitates Graft Versus Host Disease in CCR7-Deficient Bone Marrow Transplant Chimeras

Autor: Erik A.L. Biessen, Martin Lipp, Theo J.C. Van Berkel, Gijs H.M. van Puijvelde, W. E. Fibbe, Kirsten Canté-Barrett, Cathrine Husberg, Jessica M.E. van den Oever, Arne Yndestad, Saskia C. A. de Jager, Ilze Bot, Peter J. van Santbrink, Johan Kuiper, Pål Aukrust, Jaap Jan Zwaginga

Publikováno v: Transplantation. 88:631-639

Background. The development of graft versus host disease (GvHD) is one of the major challenges of bone marrow transplantations (BMTs). Although clinical symptoms of GvHD share many features with auto immune diseases, the underlying mechanisms remain

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27af392efecf1fa989ae25635598a398
https://doi.org/10.1097/tp.0b013e3181b241df

Mrassf1a-pap, a novel methylation-based assay for the detection of cell-free fetal DNA in maternal plasma

Autor: E. Joanne Verweij, Elles M. J. Boon, Sahila Balkassmi, Tim Segboer, Egbert Bakker, Jessica M.E. van den Oever, Pieter A. van der Velden, Dick Oepkes

Publikováno v: PLoS ONE, Vol 8, Iss 12, p e84051 (2013)
PLoS ONE; Vol 8
PLoS ONE, 8(12)
Van Den Oever, J M E, Balkassmi, S, Segboer, T, Verweij, E J, Van Der Velden, P A, Oepkes, D, Bakker, E & Boon, E M J 2013, ' Mrassf1a-Pap, a novel methylation-based assay for the detection of cell-free fetal DNA in maternal plasma ', PLoS ONE, vol. 8, no. 12, e84051 . https://doi.org/10.1371/journal.pone.0084051
PLoS ONE, 8(12):e84051. Public Library of Science
PLoS ONE

Objectives: RASSF1A has been described to be differentially methylated between fetal and maternal DNA and can therefore be used as a universal sex-independent marker to confirm the presence of fetal sequences in maternal plasma. However, this require

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab927743ddeb516a8b2ae4c64fc027bb
http://europepmc.org/articles/PMC3877162?pdf=render

Single Molecule Sequencing of Free DNA from Maternal Plasma for Noninvasive Trisomy 21 Detection

Autor: Maarten van Iterson, Jessica M.E. van den Oever, Egbert Bakker, E. Joanne Verweij, Mariëtte J.V. Hoffer, Jan M. M. van Lith, Elles M. J. Boon, Phebe N. Adama van Scheltema, Sahila Balkassmi, Johan T. den Dunnen, Dick Oepkes

Publikováno v: Clinical chemistry, 58(4), 699-706. American Association for Clinical Chemistry Inc.
Clinical Chemistry, 58(4), 699-706
Van Den Oever, J M E, Balkassmi, S, Verweij, E J, Van Iterson, M, Van Scheltema, P N A, Oepkes, D, Van Lith, J M M, Hoffer, M J V, Den Dunnen, J T, Bakker, E & Boon, E M J 2012, ' Single molecule sequencing of free DNA from maternal plasma for noninvasive trisomy 21 detection ', Clinical Chemistry, vol. 58, no. 4, pp. 699-706 . https://doi.org/10.1373/clinchem.2011.174698

BACKGROUND Noninvasive fetal aneuploidy detection by use of free DNA from maternal plasma has recently been shown to be achievable by whole genome shotgun sequencing. The high-throughput next-generation sequencing platforms previously tested use a PC

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4392ee3bd745d030765c1f1b4f7d0d7b
https://hdl.handle.net/1887/96816

Human Mesenchymal Stem Cells Exert Immunosuppressive Capacities by Induction of Regulatory T Cells

Autor: Kirsten Canté-Barrett, Jessica M.E. van den Oever, Willem E. Fibbe

Publikováno v: Blood. 112:2414-2414

It is widely accepted that Mesenchymal Stem Cells (MSCs) exhibit immunosuppressive capacities in vitro and in vivo. In an effort to understand the mechanism of suppression, co-cultures of MSCs with several types of immune cells have been studied. MSC

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::01f4443447d669200a93d344dd9ea3c5
https://doi.org/10.1182/blood.v112.11.2414.2414